7 Murphy N305 Thyroid Drugs

Front 1

Thyroid Drugs for Thyroid Disorders

Back 1

What does your thyroid do for you again?

Largest endocrine gland in the body
Controls how quickly body burns up energy
Make Proteins
Controls how sensitive body should be to other hormones
Makes Thyroxine and triiodothyronine (T4 and T3 hormones) to do all this!

Front 2

The principal actions for Thyroid Drugs are:
Stimulation of energy use
Stimulation of the heart
Promotion of growth and development

Back 2

Could you recite those again for me?

Front 3

So, you know that the Thyroid does and the principal actions for Thyroid Drugs would be.

What would you see if pts became deficient in thyroid hormone?

Back 3

Hypothyroidism
Myxedema (adults)
Cretinism (infants)

Front 4

Most common reasons for thyroid malfunction:
What sort of therapy would be helpful for this malfunction?

Back 4

Reasons for thyroid malfunction:
Lack of iodine, surgery, autoimmune disease; lack of TSH or TRH

Replacement therapy:
Levothyroxine (T4)
Liothyronine (T3)
Liotrix (T3+ T4)

Front 5

LEVOTHYROXINE (T4) (Synthroid)

Highly protein bound
Half-life 7 days
Uses: ?
Adverse Effects: ?

Back 5

Levothyroxine (T4) (Synthroid)

Use
– All forms of hypothyroidism

Adverse effects
– Tachycardia
– Angina
– Tremors

Front 6

There are 3 types of HYPERthyroidism:
Graves Disease, Toxic Nodular goiter, and Thyrotoxic crisis

Back 6

I'll give you fill in the blanks. Try to fill them in. The answers are on the next slide.

Front 7

Graves’ disease:
_________ thyroid hormone secretion
Mainstay of treatment: Surgery, _________, PTU

Back 7

Graves’ disease:

Excessive thyroid hormone secretion
Mainstay of treatment: Surgery, radiation, PTU

Front 8

Toxic nodular goiter (________ disease):

Thyroid _______
Mainstay of treatment: Surgery, radiation

Back 8

Toxic nodular goiter (Plummer’s disease):

Thyroid adenoma
Mainstay of treatment: Surgery, radiation

Front 9

__________ crisis (thyroid storm):

Extremely high or low thyroid hormone?
Mainstay of treatment: Potassium iodide to suppress thyroid hormone synthesis; ____-blocker

Back 9

Thyrotoxic crisis (thyroid storm):

Extremely high thyroid hormone
Mainstay of treatment: Potassium iodide to suppress thyroid hormone synthesis; beta-blocker

Front 10

PROPYLTHIOURACIL (PTU)
Inhibits or allow thyroid hormone synthesis
Short of long half -life?
Used for which of the 3 diseases we have just learned?

Back 10

Propylthiouracil (PTU)
Inhibits thyroid hormone synthesis
Short Half-Life
Used for Grave's disease and Thyrotoxic crisis

Front 11

Propylthiouracil (PTU)
Adverse effects?
This is for Hyperthyroidism. What would be one obvious answer?

Back 11

Propylthiouracil (PTU) SE:
-Agranulocytosis (within first 2 months of therapy)
-Hypothyroidism (Occurs with excessive dosing)
-*Neonatal hypothyroidism
Drug crosses the placenta and enters breast milk

Front 12

RADIOACTIVE IODINE-131

Radioactive isotope
Emits gamma and beta rays
Half-life 8 days

What is it's action?

Back 12

Radioactive Iodine-131 Action:
Produces clinical remission with destruction of thyroid gland

Front 13

And That's the end of your Thyroid Drugs! Not too many.

Before you leave, what drugs did we go over that what 3 disease are there for hyperthyroidism?

Back 13

Drugs:
Hypothyroid: Levothyroxine (T4) (Synthroid)
Hyperthyroid: Propylthiouracil (PTU)
Radioactive Iodine-131

Types: Graves disease, Plummer's Disease, Thyroid Storm