7 (Blood Bank B)

Front 1

A₁ are anti a ____

A₂ are anti a ____

A₃ are anti a ____

Back 1

A₁ are anti a (+)



A₂ are anti a ( - )



A₃ are anti a ( - )

Front 2

Where are anti-Lea, anti-Leb and Anti-Lea+b frequently found?

Back 2

In pregnant women

Front 3

What specific Lewis Antigens:
- Adsorb to RBC surface but reversible
- Poorly developed at birth

Back 3

Lea, Leb

Front 4

These antigens are described as:

- IgM agglutinins, React best at <30°
- Activate complement
- Does not cause hemolysis of transfused RBCs
- Does not cause HDN
- Enhanced by LISS, Ficin, Papain
- Provide crossmatch compatible RBCs

Back 4

Antigen anti-Lea and anti-Leb’s

Front 5

Anti-Lea and anti-Leb’s may be neutralized by?

Back 5

Soluble blood group substance such as saliva

Front 6

These Lewis Antigens are present at birth:

Back 6

I,i

(converts to I)

Front 7

These antibodies are described as:
- IgM agglutinins, React at <22°

- Enhanced by LISS, Ficin, Papain

- Do not cause hemolysis of transfused RBCs or HDN

- May interfere w/identification of allo-antibodies

Back 7

Anti-I, Anti-i

Front 8

What antibodies may interference w/identification of allo-antibodies?

Back 8

Anti-I, Anti-i

Front 9

How do you avoid the interference?

Back 9

By using pre-warming techniques

Front 10

Causes Cold Agglutinin Disease (CAD)

Back 10

Anti-I

Front 11

How does Anti-I activate complements?

Back 11

In vivo

Front 12

Antibody described as:
- Having high titer and broad thermal range

- Neutralized by soluble blood group antigen such as saliva

Back 12

Anti-I

Front 13

Antibody described as:
- Being a weak antibody

- Reactive at <30°

- Found in patients with IM

Back 13

Anti-i

Front 14

What Antibody that reacts /w cord RBCs?

Back 14

Anti-I

Front 15

What is the most common Phenotype in P blood group?

Back 15

P₁ ; the others are rare

Front 16

What is the most common Antibody in P blood group?

Back 16

Anti-P1


(rarest is Anti-P, P₁ , Anti-TJₐ)

Front 17

This antibody is described as:
- IgM agglutinin, Reacts at <30°

- Rarely causes hemolysis of transfused RBCs

- Found in P₂ individuals

- Naturalized by soluble blood group substance such as saliva

Back 17

Anti-P

Front 18

This antibody is described as:
- An infrequently encountered antibody

- Potent, hemolytic IgM antibody

- Causes transfusion reactions and HDN

Back 18

Anti-TJₐ

Front 19

This antibody reacts w/ all RBCs except with the P phenotype because it lacks P₁, P, Pk antigens

Back 19

Anti-TJₐ

Front 20

How would you treat transfusion reactions and HDN caused by Anti-TJₐ?

Back 20

Transfuse RBCs of phenotype p

Front 21

This antibody is described as:

- Either IgM or IgG; frequently encountered

- Reacts best at 22° or 4°

- Demonstrates dosage

Back 21

Anti-M

Front 22

Anti-M reactivity is enhanced at a ____ pH

Back 22

pH -6.5

Front 23

Anti-M is not reactive with _________ RBCs

Back 23

Enzyme pre-treated test RBCs

Front 24

This antibody does not cause hemolysis of M=transfused RBCsbut causes rare cases of HDN

Back 24

IgG

Front 25

This antibody is:
- Rarely encountered, IGM, Saline agglutinin

- Rare cases of HDN reported

- Not reactive w/enzyme pretreated RBCs

Back 25

Anti-N

Front 26

This antibody is described as:

- Not causing hemolysis of transfused N+ RBCs

- Typically weak cold-reactive antibody

Back 26

Anti-N

Front 27

Potent examples are made by individuals w/what phenotype?

Back 27

M+N-S-s


(treated by RBCs negative for N)

Front 28

Antibody produced by some patients undergoing hemodialysis

Back 28

Anti-‘N’

Front 29

Anti-‘N’ causes hemolysis of what?

Back 29

N+ transfused RBCs

Front 30

Antibody described as:
- IgG, immune antibody

- May bind complement and demonstrate dosage

- May cause HDN and/or hemolysis of S+ transfused RBCs

- Not reactive with enzyme pretreated test RBCs

Back 30

Anti-S

Front 31

What antibody may cause HDN or hemolysis of S+ transfused RBCS?

Back 31

Anti-S

Front 32

What do you used for treating hemolysis of S+ transfused RBCs?

Back 32

Provide S- RBC for transfusion


(Anti-S reactivity enhanced at Room temp incubation before IAT)

Front 33

Antibody that is described as:
- IgG, immune antibody

- May bind complement; May demonstrate dosage

- Reacts only w/ enzyme treated RBCs (found only in blacks)

Back 33

Anti-U

Front 34

Antibody described as:
- Cause of hemolysis of U+ transfused RBCs

- Cause of warm auto-immune hemolytic anemia

Back 34

Anti-U

Front 35

How is auto-immune hemolytic anemia treated?

Back 35

Provide U-crossmatch compatible RBCs for transfusion

Front 36

Major MNS antigens present during fetal life

Back 36

S,s,U

Front 37

Uncommonly found phenotype except in blacks

Back 37

S-s


(Blacks are most often U-)

Front 38

Kell antigens that appear in _________

Back 38

Early gestation on fetal RBCs

Front 39

Antigens that are described as:
- IgG, Immune antibodies, some IgM anti K

- React in IAT but do not bid complements

- Reactivity is not enhanced w/enzyme treated RBCs

Back 39

Kell blood group antigens

Front 40

What destroys Kell antigens?

Back 40

Sulfhydryl reagents
(DTT, ZAAP, W.A.R.M)

Front 41

How are Kidd antigens enhanced?

Back 41

By increasing serum:cell ration (4-5 drops to 1 drop)

Front 42

Blood group antigen that:

- Causes hemolysis of antigen + transfused RBCs

- Provide antigen negative RBCs for transfusion

Back 42

Kidd antigens

Front 43

Antigens that are described as:

- IgG, Immune antibodies

- React in IAT; cause HDN

- Titer frequently diminished to undetectable levels

Back 43

Kidd blood group antigens

Front 44

Kidd Blood Group Antigens are a frequent cause of:

Back 44

- Delayed hemolytic transfusion reactions

- Hemolysis of antigen + transfused RBCs


(administered Antigen negative RBCs for transfusion)

Front 45

What reagent can make Kidd blood group antigens more detectable?

Back 45

Polyspecific AHG

Front 46

Antigens that are described as:

- IgG immune antibodies

- Detected by IAT

- Rarely activates complement

Back 46

Duffy blood group antigens

Front 47

Duffy blood group antigens are a rare cause ofHDN,And only on reported cause of HDN is due to:

Back 47

Anti-Fyb

Front 48

Duffy blood group antigens do not react w/enzyme proteases but cause hemolysis of:

Back 48

Antigen + transfused RBCs

Front 49

This blood group described as:

- Major antigens are well developed at birth

- Phenotypes are only common in blacks

Back 49

Duffy blood group system

Front 50

Lutheran blood group antigens that are:

- Infrequently encountered; IgG or IgM

- Do not cause HDN

- May be Immune or non-Immune

Back 50

Anti-Luₐ and Anti-Lub

Front 51

Lutheran antigen that agglutinate RBCs at room temp or 37° and poorly developed at birth

Back 51

Anti-Luₐ and Anti-Lub

Front 52

Anti-Luₐ and Anti-Lub are non-reactive with:

Back 52

DTT-treated test RBCs

Front 53

Lutheran Blood group antigen that:

- Demonstrates mixed field agglutination

- Does not cause hemolysis of Lu(a+) transfused RBCs

Back 53

Anti-Lub

Front 54

May cause hemolysis of Lu(b+) transfused RBCs

Back 54

Anti-Lub


(treat with Lu(b-) RBCs for transfusion)