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8 Cards in this Set
- Front
- Back
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What are the two main categories of neurodegenerative conditions?
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Dementia and Movement disorders
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What is the model of neurodegenerative diseases?
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Normal proteins are misfolded...results in cell death/chaperone correction/tangles (BAD)/senile plaques (BAD)...
Generalized, diffuse cerebral atrophy |
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What is the model of Alzheimers disease?
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INTRAcellular Neurofibrillary tangles (made up of aggregated abnormal Tau protein - paired helical filament) and EXTRAcellular senile plaques (MAJOR LESION OF AD - made of Amyloid B, abnormally cleaved from APP).
NOTED ATROPHY OF HIPPOCAMPUS, ENTORHINAL CORTEX, MEDIAL TEMPORAL CORTEX |
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What is Tau?
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Tau is a microtubule associated protein that attaches to and stabilizes microtubules. It is hyperphosphorylated and can result in tangle formation.
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What are senile plauqes? Are they all bad?
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Diffuse plaques (less condensed) seen in virtually ALL aging patients. Bad plaques are MORE CONDENSED (neuritic and mature type). SENILE PLAQUES MADE UP OF STRAIGHT FILAMENTS MADE UP OF A-Beta peptide.
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How do you make postmortem AD diagnosis?
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Must have premortem diagnosis of dementia. Imaging of brain to determine extent of NFT and senile plaques.
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Type of inclusions in Parkinsons?
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Lewy bodies. Small black inclusions made up of alpha-synuclein. Pale halo, eosinophilic core. Increased expression of alpha-synuclein can lead to disease onset. LEWY BODIES FOUND IN OTHER DISEASES, NOT JUST PARKINSONS
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Type of inclusions in ALS? Other ALS info?
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Ubiquitin/TDP-43 positive inclusions in MOTOR NEURONS
Degeneration of corticospinal tracts...demyelination of white matter. CORTICOSPINAL DEGENERATION AND MOTOR NEURON CELL BODY LOSS (ANTERIOR ROOT ATROPHY) |
