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26 Cards in this Set
- Front
- Back
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What is the MOA of prednisone?
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lymphocytopenia
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What is the MOA and side effects of vincristine?
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MOA--binds to tublin, mitotic inhibitor Side Effects--peripheral neuropathy, phlebitis (vein inflammation), alopecia, multiple GI problems
**areas where cells multiply |
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What is the famous combo for ALL?
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POMP: prednisone, oncovin, methotrexate, purimethol (ie 6-MP)
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What is the MOA and side effects of 6-MP?
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inhibits RNA synthesis Side effects--stomatitis, bone marrow suppression, alopecia, nausea and vomiting, renal and hepatic damage
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What is the treatment of Wilm's tumor (congenital kidney tumor), affects 2-5 yo?
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Dactinomycin (kids ACT up) and vincristine
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What is the trmnt for Hodgkin's disease (lymphoma)?
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MOPP: Mechlorethamine, Oncovin, Prednisone, Procarbazine
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What is the MOA and side effects of mecholorethamine?
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MOA-alkylating agent
Side Effects-nausea/vomiting, extreme bone marrow suppression, herpes zoster, extensive blisters (skin or mucous membranes) |
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What is the MOA and side effect of Procarbazine?
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MOA-inhibits DNA and RNA synthesis Side Effects- bone marrow suppression, disulfiram reactions, neurotoxicity (drowsiness-->hallucinations/paresthesia)
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What is the unique side effect of cyclophosphamide?
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hemorrhaghic cystitis-->bladder fibrosis
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What is the unique side effect of bleomycin?
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pulmonary fibrosis
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What is the unique side effect of Cisplatin?
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peripheral neuropathy (ie parasthesias and loss of proprioception)
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What is the unique side effect of L-asparaginase?
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hypersensitivities (allergic reactions)
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What are the side effects of 6-MP?
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bone marrow suppression, very severe
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What is the unique side effect of cytarbine?
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stomatitis (inflamm of mucous membranes), nause, and vomiting
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What is the unique side effect of 5-FU?
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GI problems, nausea and vomiting
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What is the unique side effect of actinomycin?
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SEVERE dose limiting bone marrow suppression, stomatitis, alopecia, immunsuppresion
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What is the unique side effect of doxi-rub-icin?
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red urine & cardiotoxicity (dilated cardiomyopathy)
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What is the unique side effect of bleomycin?
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lung fibrosis
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What are the alkylating agents and their side effect?
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vincristine, vinblastine, mechlorethamine, chlorambucil
Side effects: bone marrow suppression & secondary cancer |
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What is Leuprolide used to treat and its side effects?
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prostatic cancer. side effects-->leuprolide: hot flashes MOA: GnRH analog
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What is flutamide used to treat and its side effects?
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prostate cancer, MOA, feedback mechanisms, suppresses sex hormone synthesis by antagonizing the testosterone receptor.
Side Effects--gynecomastia |
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What is the MOA of hydroxyurea?
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inhibits ribonucleotide reductase (enzyme key to nucleotide synthesis in wbcs). Also induces synthesis of fetal hemoglobin-->useful in sickle cell patients
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What is trans retoinic acid used for and side effect? hint-specific cancer
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AML subtype 3, DIC
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What is the use and MOA of tamoxifen?
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estrogen receptor modulator, inhibits estrogen receptors, breast cancer
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What are the side effects of Tamoxifen?
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hot flashes, increased risk of DVT, PE, endometrial cancer
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What is the MOA of taxanes (paclitaxel and docetaxel)?
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inhibits microtubule disassembly, results in apoptosis, side effect: dose limiting bone marrow suppression
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