6.3 Immuno Ii

Front 1

1. What diagnostic test is used to diagnose Type I hypersensitivity reactions?

2. What type of hypersensitivity is Guillain-Barre syndrome?

3. Describe the etiology of hyperacute post-transplant rejection and the timeline for it?

Back 1

1. scratch test

2. Type IV

3. preformed donor antibodies in the transplant recipient; occurs within hours

Front 2

1. What diagnostic test is used to diagnose Type II hypersensitivity reactions?

2. What type of hypersensitivity reaction is contact dermatitis?

3. Describe the etiology of acute post-transplant rejection and the timeline for it?

Back 2

1. direct/indirect Coombs test

2. Type IV

3. CTL against foreign MHC; occurs in weeks

Front 3

1. What diagnostic test is used to diagnose Type III hypersensitivity reactions?

2. What type of hypersensitivity reaction is IDDM?

3. Describe the etiology of chronic post-transplant rejection and the timeline for it?

Back 3

1. immunofluorescent staining

2. Type IV

3. CTL against vasculature; months/years after transplant

Front 4

1. What is an arthus reaction and what type hypersensitivity is it?

2. What type of hypersensitivity reaction is RA?

3. Describe the etiology of graft-versus-host disease?

Back 4

1. intradermal injection of Ab causes formation of Ab/Ag complexes with edema/necrosis; type III

2. Type III

3. immunocompetent T-cells begin attacking an immunocompromised host's tissue after transplant

Front 5

1. What is serum sickness and what type of hypersensitivity is it?

2. What type of hypersensitivity reaction is Hashimoto's thyroiditis?

3. Diagram the pathway to the various immune deficiencies?

Back 5

1. parenteral Ab induces Ab/Ag complexes that deposit in various tissues; Type III

2. Type IV

3. SEE SHEET

Front 6

1. What type of hypersensitivity is MS?

2. What is an indication for recombinant β-interferon?

3. What is an indication for recombinant α-interferon?

Back 6

1. Type IV

2. MS

3. hepatitis B/C

Front 7

1. What type of hypersensitivity is Polyarteritis Nodosum?

2. What is an indication for γ-interferon?

3. Diagram the VitD activation pathway?

Back 7

1. Type III

2. Chronic Granulomatous Disease

3. SEE SHEET

Front 8

1. What is the molecular defect in Bruton's agammablobinemia?

2. What is Job's syndrome? What Ig is associated with this condition?

3. Ataxia-Telangectasia is associated with what Immunoglobin pathology?

Back 8

1. BTK tyrosine kinase defect

2. defective PMN signalling d/t ↓INF-G by T cells; ↑IgE

3. ↓IgA

Front 9

1. What is the molecular defect in Hyper IgM syndrome?

2. Diagnose: delayed separation of umbillicus and absent pus formation?

3. Compare the number of B cells and Ig in CVI and Bruton's agammaglobinemia?

Back 9

1. Defect in T-cell CD40Ligand (result: T-cell can't stimulate the CD40 on the B-cell)

2. Leukocyte Adhesion Deficiency (LFA-1)

3. CVI: normal number of B cells but no IgM or plasma cells; Bruton's: no B cells OR IgM

Front 10

1. What pathologies are associated with Anti-Jo autoantibodies?

2. HLA-A3 is associated with what pathology?

Back 10

1. polymyositis, dermatomyositis

2. Hemochromatosis

Front 11

1. What pathology is associated with anti U1 RNP (ribonucleoprotein) autoantibodies?

2. HLA-B8 is associated with what pathology?

Back 11

1. mixed connective tissue disease

2. Grave's disease

Front 12

1. What pathology is associated with c-ANCA autoantibodies?

2. What diseases are associated with HLA-DR?

3. List the diseases associated with granulomas?

Back 12

1. Wegener's granulomatosis

2. HLADR: Hashimotos(5), LupusSLE(2), AnemiaPernicious(5), DM(3/4), RA(4)

3. Leprosy/Tb, Crohn's, Cat-scratch, Syphillis, Sarcoid, Berylliosis

Front 13

1. What pathology is associated with glutamate decarboxylase antibodies?

2. What cytokines/cells are involved in granuloma formation?

3. What pathology is associated with smooth muscle antibodies?

Back 13

1. IDDM

2. INF-G from Th1 cells cause monocytes→macrophages→epithelioid cell→giant cell

3. autoimmune hepatitis