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6 Cards in this Set
- Front
- Back
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True or False:
Parkinson Disease is the commonest neurodegenerative disorder. |
False.
Parkinson's disease (PD) is the second commonest neurodegenerative disease, exceeded only by Alzheimer's disease (AD). |
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What is the mean age of onset for Parkinson Disease?
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The mean age of onset is about 60 years, but cases can be seen in patients in their 20s, and even younger.
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What are the four cardinal features of Parkinson Disease?
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Rest tremor
Rigidity Bradykinesia Gait impairment |
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Name four nondopaminergic features of Parkinson disease. Why are they referred to as nondopaminergic?
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Additional features can include freezing of gait, postural instability, speech difficulty, autonomic disturbances, sensory alterations, mood disorders, sleep dysfunction, cognitive impairment, and dementia, all known as nondopaminergic features because they do not fully respond to dopaminergic therapy.
Other features of the disease include: Micrographia Masked facies (hypomimia) Reduced eye blink Soft voice (hypophonia) Dysphagia Anosmia Sensory disturbances (e.g., pain) Mood disorders (e.g., depression) Autonomic disturbances Orthostatic hypotension Gastrointestinal disturbances Genitourinal disturbances Sexual dysfunction |
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What are three pathological hallmark features of Parkinson disease?
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Degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNc)
Reduced striatal dopamine Lewy bodies (intracytoplasmic proteinaceous inclusions) |
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Parkinsonism is a general term that is used to define a symptom complex manifest by bradykinesia with rigidity and/or tremor. What percentage of cases of Parkinsonism are due to Parkinson Disease?
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Among the different forms of parkinsonism, PD is the most common (approximately 75% of cases).
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