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17 Cards in this Set

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What is the rash in kawasaki syndrome called? Why?
Polymorphous - it can assume a variety of forms in different patients
What are the 5 diagnostic criteria for kawasaki syndrome?
-Fever of 5 days with no other etiology
-Bilateral nonpurulent conjunctivitis
-Mucosal involvement - chapped lips
-Edema/red hands and feet in acute
-Polymorphous rash on trunk
-Cervical lymphadenopathy
What happens to the erythema and edema of the hands/feet in subacute kawaski?
They desquamate at the periungual areas
What develops by day 10 in kawasaki syndrome?
Thrombocytosis - platelets skyrocket above 450,000 and remain for several weeks
What IS kawasaki?
Generalized vasculitide with unknown cause by probably infectious
In what age group/sex is Kawasaki more common?
<5 yrs old
Slightly more boys
What is the most serious potential kawasaki complication?
Coronary aneurysm
What age group is most likely to not develop sufficient diagnostic criteria? Why is this important?
Infants - these are the most likely to get coronary aneurysms
What 4 CBC levels are typical in kawasaki?
-Normocytic anemia
-Leukocytosis
-Elevated ESR/CRP
What UA/CSF findings support it?
-Sterile pyuria
-Pleiocytosis in CSF
What is the treatment for kawasaki syndrome?
-High dose aspirin initially then 6-8 weeks of thrombotic prophylaxis
-IVIG
What % of kawasaki patients develop coronary artery dilation and giant aneurysms?
5% dilation
1% giant aneurysm
What majorly important thing must you remember in Kawasaki patients at follow up visits?
NO live vaccines for 11 months following IVIG therapy - it interferes with the immune response
Which 2 live vaccines must you remember this about?
-MMR
-Varicella
What if the vaccines ARE given?
You'll have to reimmunize unless serologic testing indicates adequete titers
What vaccine SHOULD kawasaki disease patients on long term aspirin thx get and why?
Influenza - they're at risk for Reye syndrome if they're infected while on aspirin
What are 6 risk factors for coronary aneurysms?
-Male
-Early echo changes - mitral regurg or pericardial effusion
-Age < 1yo
-Thrombocytosis
-Fever > 10d