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11 Cards in this Set
- Front
- Back
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Essentially what is ET?
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overproduction of platelets; all the other cells are fine.
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What are the 2 main types of problems in ET?
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-Problems causesd by overactive platelets in circulation
-Primary megakaryo abnormalities |
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what problems do platelets cause?
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-Lo-grade intravascular clotting
-Immune complexes -Leukoproteins -Abnormal blood flow |
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What are the primary meg abnormalities?
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1. Abnormal stem clone causes overprod of ineffective platelets, normals are supprsd.
2. Platelets are less dense b/c of ploidy # increase; granules aren't good. |
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How do symptoms progress in ET patients?
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Initial: asymptomatic
Later: anemia, hemorrhage, thrombotic episodes, Splenomegaly, death in 5 yrs |
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What does ET need to be differentiated from?
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Reactive thrombocytosis
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What sorts of lab results indicate ET?
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-V. high plt: 600-2500
-Platelet clumps on PBsmear Look large, but normal volume. -Abnormal function in bleeding time/aggregation. |
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What problems for bone marrow procedure are encountered in ET?
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-Rapid clotting during aspiration b/c of platelets
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what does the BM smear show, if you can get one?
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-Meg hyperplasia, increased platelets/clumps.
-Erythroid/myeloid hyperplasia -Iron stores are fine. |
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What does the Pb smear show in ET?
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LOTS OF PLATELETS
-No Ph' chromosome, mild leukocytosis, maybe normal. -Normal LAP |
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How is a mkd increase in platelets treated?
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with aspirin to defucnctionalize the thrombotic effect.
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