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34 Cards in this Set

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Cotinine:
metabolite of nicotine; used for screening
increase in Anion gap metabolic acidosis in alcohol abuse:
lactic acid, B-hydroxybutyric acid
Aplastic anemia:
chloramphenicol, alkylating agents
Hemolytic anemia:
penicillin, methyldopa, quinidine
Macrocytic anemia:
Methotrexate (most common), phenytoin, oral contraceptives, 5-fluorouracil
Platelet dysfunction:
Aspirin, other NSAIDs
Thrombocytopenia:
Heparin (most common), quinidine
Congestive Cardiomyopathy:
Doxorubicin, daunorubicin
Tinnitus, verigo:
Salicylates
Angioedema:
ACE inhibitors
Maculopapular rash:
Penicillin
Photosensitive rash:
Tetracycline
Urticaria:
Penicillin
Hemorrhagic gastritis:
Iron, salicylates
Cholestasis:
Oral contraceptives, estrogen, anabolic steroids
Fatty change:
amiodarone, tetracycline, methotrexate
Hepatic adenoma:
Oral contraceptives
Liver necrosis:
Acetaminophen (most common), isoniazid, salicylates, halothane, iron
Asthma:
Aspirin, other NSAIDs
Interstitial fibrosis:
Bleomycin, busulfan, nitrofurantoin, methotrexate
Drug induced lupus:
procainamide, hydralazine
Arsenic:
Diarrhea, convulsions, squamous cell carcinoma of skin, liver angiosarcoma, lung cancer
Asbestos:
Primary lung cancer, mesothelioma
Benzene:
Acute leukemia, aplastic anemia
Carbon monoxide:
Headache (first sign), cherry-red skin, coma
Cyanide:
Seizures
Ethylene glycol:
increased anion gap metabolic acidosis. Acute renal failure
Isopropyl alcohol:
deep coma
Lead:
Microcytic anemia with coarse basophilic stippling, nephrotoxicity in proximal tubule
Methanol:
Increased anion gap metabolic acidosis. Blindness due to optic atrophy
Organophosphates:
miotic pupils, paralysis. decreased serum and red blood cell cholinesterase levels
Polyvinyl chloride:
liver angiosarcoma
Most common cause of death in burn patients:
sepsis caused by pseudomonas aeruginosa
UVB:
increase in pyrimidine dimers distorts DNA helix. inact TP53. Act RAS.