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8 Cards in this Set
- Front
- Back
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What is the physiological pH?
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7.4 - at which the amino acid has COO- and NH3+
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What is the amino acid mutation of sickle cell anemia?
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Glutamate --> Valine in Beta subunit of hemoglobin
Polar to nonpolar |
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Which amino acid contributes to collagen's fibrous structure?
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Proline - imino acid - 5 membered ring - good for fibrous but interrupts globular protein structure
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Special property of histidine; where is it found
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side chain NH3 can be either + or neutral depending in ionic environment provided by polypeptide chain of protein; hemoglobin
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Genetic disease is usually caused by what defective protein, according to Schmid Lec 6?
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Ras (50% colon cancers, 90% pancreatic cancers)
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What is the primary mutation of Cystic Fibrosis
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(Delta)Phe508 in CFTR
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What is the driving force for protein folding?
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water structure (organized water --> folded protein + free water)
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What is the largest contributing interaction in a protein?
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Hydrophobic
Hydrogen bonds and electrostatic bonds are small because of compensation van der Waals are only at close distances |
