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5 Cards in this Set
- Front
- Back
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histologic features in Celiac disease
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flattened mucosa
atrophy of villi chronic inflammation in lamina propria increased intraepithelial lymphocytes |
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Histology in whipple disease
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Lymphatic destruction
Foamy macrophages in lamina propria Macrophages have PAS positive granules (in EM can see actinomycte Tropheryma whippelii) |
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Autoantibodies in Celiac Disease
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Anti-tissue transglutaminase IgA- tTG(~98% sensitive and specific)
Anti-endomysial IgA- EMA (~95% sens and spec) Anti-gliadin (80%) |
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Celiac disease pathogenesis
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Inappropriate T cell and IgA response against gliadin
Associated with HLA-DQ2 (95%) and HLA-DQ8 (5%) Tissue transglutaminase has important role--> deaminates gluten in lamina propria--> phagocytosis in antigen presenting cells--> presented (w DQ2 or 8) to gluten specific CD4+ cells--> cytokine release which activate matrix metaloproteases resulting in cell death and degradation |
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4 Autoimmune skin disorders
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1 Chronic cutaneous lupus erythromatous- malar rash exacerbated by sunlight
2 Pemphigus vulgaris- suprabasal vesicles 3 Bullous pemphigoid- subepidermal vesicles 4 Dermatitis Herpetiformis- subepidermal vesicles with neutrophils |
