6-03 Cancer

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neoplasm associated with chronic atrophic gastritis, pernicious anemia, postsurgical gastric remnants

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diseases associated with gastric adenocarcinoma

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neoplasm associated with tuberous sclerosis (facial angiofibromas-formerly adenoma sebaceum; seizures; MR)

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diseases associated with astrocytoma and cardiac rhabdomyoma

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neoplasm associated with actinic keratosis

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diseases associated with squamous cell carcinoma of skin

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neoplasm associated with Barrett's esophagus (chronic GI reflux)

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diseases associated with esophageal adenocarcinoma

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neoplasm associated with Plummer-Vinson syndrome (iron defiency --> anemia, esophageal webs, atrophic glossitis)

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diseases associated with Squamous cell carcinoma of esophagus

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neoplasm associated with Cirrhosis

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diseases associated with HCC

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neoplasm associated with Ulcerative colitis

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diseases associated with Colonic adenocarcinoma

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neoplasm associated with Paget's disease of bone

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diseases associated with 2' osteosarcoma and fibrosarcoma

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neoplasm associated with Immunodeficiency states

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diseases associated with malignant lymphomas

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neoplasm associated with AIDS

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diseases associated with Aggressive malignant Non-Hodgkin's lymphomas, Kaposi's sarcoma

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neoplasm associated with Autoimmune diseases (eg Hashimoto's thyroiditis, Myasthenia gravis)

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diseases associated with benign and malignant thymoma

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neoplasm associated with Acanthosis nigricans (hyperpigmentation and epidermal thickening)

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diseases associated with visceral malignancies (stomach, lung, breast, uterus)

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neoplasm associated with Dysplastic nevus

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diseases associated with Malignant melanoma

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associated with what tumor? abl

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name the oncogone / tumor suppressor: CML

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associated with what tumor? c-myc

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name the oncogone / tumor suppressor: Burkitt's lymphoma

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associated with what tumor? bcl-2

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name the oncogone / tumor suppressor: Follicular and undifferentiated lymphomas (inhibits apoptosis)

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associated with what tumor? erb-B2

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name the oncogone / tumor suppressor: Breast, ovarian, and gastric carcinomas

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associated with what tumor? ras

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name the oncogone / tumor suppressor: Colon carcinoma

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associated with what tumor? L-myc

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name the oncogone / tumor suppressor: Lung tumor

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associated with what tumor? N-myc

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name the oncogone / tumor suppressor: Neuroblastoma

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associated with what tumor? ret

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name the oncogone / tumor suppressor: MEN II and III (IIB)

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associated with what tumor? Rb (13q)

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name the oncogone / tumor suppressor: Retinoblastoma, osteosarcoma

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associated with what tumor? BRCA 1 and 2 (17q, 13q)

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name the oncogone / tumor suppressor: Breast and ovarian cancer

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associated with what tumor? p53 (17p)

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name the oncogone / tumor suppressor: Li-Fraumeni syndrome, most human cancers

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associated with what tumor? p16 (9p)

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name the oncogone / tumor suppressor: Melanoma

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associated with what tumor? APC (5q)

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name the oncogone / tumor suppressor: Colorectal cancer

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associated with what tumor? WT1 (11q)

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name the oncogone / tumor suppressor: Wilms tumor

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associated with what tumor? NF1 (17q)

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name the oncogone / tumor suppressor: Neurofibromatosis I

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associated with what tumor? NF2 (22q)

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name the oncogone / tumor suppressor: Neurofibromatosis II

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associated with what tumor? DPC (18q)

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name the oncogone / tumor suppressor: Pancreatic cancer

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associated with what tumor? DCC (18q)

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name the oncogone / tumor suppressor: Colon cancer

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associated with what tumor? PSA

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name the marker: Prostate Carcinoma, used for screening

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associated with what tumor? CEA

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name the marker: Colorectal and Pancreatic cancer (also gastric and breast carcinomas)

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associated with what tumor? AFP

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name the marker: Hepatocellular carcinomas

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associated with what tumor? AFP

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name the marker: Nonseminomatous germ cell tumors of the testis (eg yolk sac tumor)

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associated with what tumor? B-HCG

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name the marker: Hydatidiform moles, Choriocarcinomas, Gestataionl trophoblastic tumors

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associated with what tumor? CA-125

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name the marker: Ovarian, malignant epithelial tumors

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associated with what tumor? S-100

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name the marker: Melanoma, neural tumors, astrocytomas

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associated with what tumor? Alkaline Phosphatase

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name the marker: Mets to bone, Paget's disease of bone (excess osteoclast activity), obstructive biliary disease

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associated with what tumor? Bombesin

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name the marker: Neuroblastoma, lung and gastric cancer

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associated with what tumor? TRAP (tartrate-resistant acid phosphatase)

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name the marker: Hairy B-cell leukemia

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associated with what tumor? HTLV-1

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name the assoc virus: Adult T-Cell Leukemia

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associated with what tumor? HBV/HCV

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name the assoc virus: HCC

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associated with what tumor? EBV

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name the assoc virus: Burkitt's lymphoma, nasopharyngeal carcinoma

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associated with what tumor? HPV

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name the assoc virus: Cervical carcinoma (16,18), penile/anal carcinoma

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associated with what tumor? HHV-8

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name the assoc virus: Kaposi's sarcoma, boty cavity fluid B-cell lymphoma

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associated with what tumor? Psammoma Bodies

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PSaMMoma: Papillary (thyroid), Serous (ovary), Meningioma, Mesothelioma

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associated with what organ? Aflatoxins

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name the associated toxin: HCC

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associated with what organ? Vinyl Chloride

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name the associated toxin: Liver (angiosarcoma)

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associated with what organ? CCl4

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name the associated toxin: Liver (centrilobular necrosis, fatty change)

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associated with what organ? Nitrosamines

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name the associated toxin: Esophagus, stomach

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associated with what organ? Cigarette smoke

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name the associated toxin: Larynx, Lung

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associated with what organ? Asbestos

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name the associated toxin: Lung (mesothelioma, bronchogenic carcinoma)

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associated with what organ? Arsenic

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name the associated toxin: Skin (squamos cell carcinoma)

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associated with what organ? Naphtalene (analine) dyes

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name the associated toxin: Bladder (transitional cell carcinoma)

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associated with what organ? Alkylating agents

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name the associated toxin: Blood (leukemia)

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associated with what tumor? ACTH / ACTH-like-peptide (--> Cushing's syndrome)

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paraneoplastic effects of: Small cell lung carcinoma

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associated with what tumor? ADH (SIADH)

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paraneoplastic effects of: Small cell lung carcinoma and intracranial neoplasms)

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associated with what tumor? Hyperclacemia

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paraneoplastic effects of: Squamous cell lung carcinoma, RCC, breast carcinoma, multiple myeloma, bone mets (via PTHrp, TGF-b, TNF-a, IL-1)

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associated with what tumor? Polycythemia

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paraneoplastic effects of: RCC, hemangioblastoma (EPO)

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associated with what tumor? Lambert-Eaton syndrome (muscle weakness)

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paraneoplastic effects of: Thymoma, small cell lung carcinoma (Abs against Ca++ channels at neuromuscular junction)

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associated with what tumor? Gout, urate nephropathy

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paraneoplastic effects of: Leukemias and lymphomas (excess nuclear acid turnover, esp with cytotoxic tx)

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Brain mets

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50% of brain tumors are mets. "Lots of Bad Shit Kills Glia" (Lung, Breat, Skin-melanoma, Kidney, GI)

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Liver mets

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"Cancer Sometimes Penetrates Benign Liver" (Colon > Stomach > Pancreas > Breast > Lung)

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Bone mets

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"P.T. Barnum Loves Kids:" Prostate, Thyroid, Testes, Breast (Both lytic and Blastic), Lung (Lytic), Kidney; Breast and Prostate are most common; Mets >> 1' bone tumors

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Cancer Epi, Men

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Incidence: Prostate > Lung > Colon/Rectum; Mortality: Lung > Prostate

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Cancer Epi, Women

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Incidence: Breast > Lung > Colon/rectum; Mortality: Lung > breast (replace male Prostate with Breast)