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12 Cards in this Set
- Front
- Back
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Gestational Trophoblastic Neoplasia (GTN) is a rare variation of pregnancy and usually presents as what type of pregnany?
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Molar Pregnancy:
Gestational trophoblastic neoplasia (GTN) is a rare variation of pregnancy of unknown etiology and usually presents as a benign disease called hydatidiform mole (molar pregnancy). GTN is a clinical spectrum that includes all neoplasms that derive from abnormal placental (trophoblastic) proliferation. |
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What are the 2 types of molar pregnancies?
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Complete mole (no fetus), and Incomplete mole (fetal parts in addition to molar degeneration.)
Persistent or malignant disease will develop in approximately 20% of patients with molar pregnancy. Persistent or malignant GTN is responsive to chemotherapy. |
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Key clinical features of GTN include: (1) clinical presentation as pregnancy, (2) reliable means of diagnosis by pathognomonic ultrasound findings, and (3) a specific tumor marker. What is the tumor marker?
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Quantitative serum human chorionic gonadotropin [hCG].
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T/F:
Persistent GTN may occur with any pregnancy, although it most commonly follows molar pregnancy. |
TRUE
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The highest incidence of molar pregnancies occurs among women of what ethnic group?
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The highest incidence occurs among Asian women living in Asia (1 in 200 pregnancies).
The incidence in the United States is approximately 1 in 1500 pregnancies, with a recurrence rate of 1% to 2%. It is more common in older women. |
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Molar pregnancies are associated with low dietary ______ consumption and vitamin ___ deficiency.
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Carotene & Vitamin A
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Women with PARTIAL molar pregnancies tend to have a history of what 2 things?
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Infertility and spontaneous abortion.
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A hydatidiform mole includes abnormal proliferation of the _______________ and replacement of normal placental trophoblastic tissue by ___________ __________ ________
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1) Syncytiotrophoblast
2) Hydropic Placental Villi |
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__________ moles do not have identifiable embryonic or fetal structures.
________ moles are characterized by focal trophoblastic proliferation, degeneration of the placenta, and identifiable fetal or embryonic structures. |
1)Complete
2) Partial |
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Complete moles have chromosomes entirely of _______ origin (Maternal or paternal)?
How does this occur |
PATERNAL:
This is the result of the fertilization of a blighted ovum by a haploid sperm that reduplicates, or rarely, fertilization of a blighted ovum with two sperm. |
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What is the usual karyotype of complete mole?
What is the usual karyotype of a partial mole? |
Complete:
46XX (rarely 46XY) Partial: Triploid- One haploid set of maternal chromosomes and two haploid sets of paternal chromosomes, the consequence of dispermic fertilization of a normal ovum. |
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Which type of mole is more common: PARTIAL OR COMPLETE?
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COMPLETE
Complete moles are more common than partial moles and are more likely to undergo malignant transformation. |
