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14 Cards in this Set
- Front
- Back
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Phenytoin indication
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Partial seizure
Status epilepticus |
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Phenytoin PK
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good bioavailability
erratic absorption non-linear PK |
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Phenytoin metabolized by
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CYP 2C9, 2C19
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Phenytoin Adverse effects
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Nystagmus
ataxia confusion encephalopathy rash hirusutism gingival hyperplasia osteoporosis |
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Phenytoin MOA
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Na channels, prolongs fast activation
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Carbamazepine MOA
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Na channels, prolongs fast activation
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Carbamazepine PK
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Auto induction (must titrate up)
broad inducer active metabolite protein bound low solubility (no IV form) erratic absorption |
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Carbamazepine AE
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diplopia
dizzy nystagmus rash hyponatremia |
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Carbamazepine metabolized by
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liver
cyp3A4 |
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Carbamazepine indicated
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Partial onset seizure
2nd gen. |
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VPA indication
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partial
1 gen |
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VPA PK
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good absorption
saturable protein binding |
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VPA AE
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drowsy
weight gain hepatitc toxicity (0-2 yo) tremor confusion hyperammonemia inhibition of platelet aggregation, lower platelet count menstural irregularities PCOS pancreatitis |
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VPA metabolized by
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glucuronidation
beta oxidation in liver |
