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21 Cards in this Set
- Front
- Back
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What is the method of action of Amphotericin B?
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Binds Ergosterol and forms membrane pores
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What are the clinical uses for Amphotericin B?
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Serious, systemic mycoses
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What are the toxicities of Amphotericin B?
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Fever/chills, HpoTN, Nephrotoxicity, Arrhythmias, anemia, IV phlebitis
VERY TOXIC |
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What is the mechanism for Nystatin?
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Same as Amphotericin B, creates pores in the membrane by binding ergosterol
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What are the uses for Nystatin?
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"Swish and swallow" for oral candidiasis
Topical for diaper rash or vaginal candidiasis NO IV USE |
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What are the 6 Azoles?
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Fluconazole, Ketoconazole, Clotrimazole, Miconazole, Itraconazole, Voriconazole
FCK MI V (F*** my V) |
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What is the mechanism for Azoles?
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Inhibit fungal sterol synthesis by inhibiting P-450 conversion from lanosterol to ergosterol
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What is the specific use for Azoles?
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Cryptococcal meningitis in AIDS patients
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What else are azoles used for?
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All types of candidal infections
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What is Itraconazole used specifically for?
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Sporotrichosis
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What are the side effects of Azoles?
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Testosterone synthesis inhibition (gynecomastia)
Liver dysfunction (inhibits P-450) |
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What is the mechanism for Flucytosine?
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Inhibits DNA and RNA by converting to 5-FLUorouracil
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What is the use for Flucytosine?
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Systemic fungal infections in combo with Amphotericin B
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What is the mechanism for Caspofungin/Micafungin?
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Inhibits cell wall synthesis by inhibiting synthesis of B-Glucan
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What are the uses for Caspofungin/Micafungin?
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Invasive Aspergillosis, Candida
"cASPofungin and ASPergillosis" |
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What is the mechanism for Terbinafine?
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Inhibits fungal enzyme squalene epoxidase
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What is Terbinafine used for?
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Dermatophytoses (ONYCHOMYCOSIS), ringworm, athletes foot
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What is the mechanism for Griseofulvin?
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Interferes with microtubule function, disrupts mitosis
DEPOSITS IN KERTIN-CONTAINING TISSUES |
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What are the uses for Griseofulvin?
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Oral - superficial infections
Inhibits growth of dermatophytes Tina, Ringworm, Onychomycosis |
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What are the 5 side effects of Griseofulvin?
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Teratogenic
Carcinogenic Confusion HA's Inc P450 and warfarin metabolism |
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What antifungal is used intrathecally for fungal meningitis?
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Ampho B
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