5.22 Qbank

Front 1

1. If a cancer is going to spread into the peritoneum, what is the likely origin of said cancer? (2 possibles)

2. What EKG abnormality is associated with Rheumatic fever?

3. What deficiency is associated with Gaucher's disease?

Back 1

1. ovarian first, colon second

2. prolonged PR interval

3. Glucocerebrosidase

Front 2

1. What's the only cranial nerve that exits the brainstem dorsally?

2. What is the structure affected for a "phantom calcification"?

3. What is the EKG abnormality associated with coronary artery disease?

Back 2

1. CNIV Trochlear

2. Focal calcification NEAR the lung...but not the lung. Costal cartilagenous portion of the rib

3. wide QRS

Front 3

1. What eye-related CN can be damaged by frontal head trauma?

2. Osteopetrosis is due to a defect in which cell line?

3. Which direction do internal and external obliques lie?

3. Describe inheritance of the Lysosomal storage diseases and the exceptions to the rule?

Back 3

1. CNIV (most anterior in orbit)

2. Osteoclast doesn't break down bone properly

3. External "hands in pockets", internal 90 degrees different

3. AR, except Fabry's and Hunter's (XR)

Front 4

1. Which cranial nerve lies next to and can be affected by the posterior communicating artery?

2. You're a surgeon making an abdominal incision. List the order of the structures you penetrate?

3. What deficiency is associated with Metachromic Leukodystrophy?

Back 4

1. CNIII

2. skin, Campers (fatty), Scarpas (fibrous), external oblique, internal oblique, transversalis muscle, transversalis fascia, parietal peritoneum

3. Arylsulfatase

Front 5

1. Which cranial nerve lies next to and can be affected by the superior cerebellar artery?

2. Both ethylene glycol (anti-freeze)
and aspirin) would cause renal problems with acidosis. How do you tell the difference between the two?

3. Both VEGF and Adenosine increase in excersized muscles. Which returns to baseline faster and why?

Back 5

1. CNIII

2. oxalate crystals

3. Adenosine has a short half-life, returns to baseline much faster. VEGF has a longer halflife

Front 6

1. Diagnose: 5 y/o with mulitlocular cyst with brown viscous fluid over the optic chiasm?

2. Diagnose: golden brown testicular tumor?

3. Prolactin has its own endocrine axis. Draw this axis

Back 6

1. Rathke's pouch tumor

2. Leydig tumor

3. See pg. 281 of FA

Front 7

1. What is the relationship between clearance of a substance (creatinine) and plasma concentration of the substance (creatinine)?

2. Describe how prolactin influences gonadotropins?

3. Diagnose: Helmet-shaped cells and schistocytes on blood smear?

Back 7

1. ClCr=U*V/Pcr (inverse relationship between ClCr and Pcr

2. Prolactin inhibits GnRH which causes a reduction in LH and FSH

3. DIC

Front 8

1. Where do (a) cryptosporidium, (b) shigella and (c) entameoba histolytica cause their damage in the intestinal mucosa, brush border or mucosa?

2. What is halothane hepatitis?

3. What are the only conditions that would cause schistocytes? (3)

Back 8

(a) cryptosporidium: brush border (b/c) shigella/entameoba histolytica: submucosa

2. Duh...it's hepatitis caused by halothane.

3. DIC, prosthetic valves, HUS/TTP

Front 9

1. Draw the blood supply to the arm and all of its branches?

2. What chromosome abnormality is associated with Cri-Du-Chat?

3. What is heterotopia?

Back 9

1. SEE SHEET

2. Microdeletion at Chr. 5

3. Displacement of a normal tissue into an ectopic site (eg. endometriosis)

Front 10

1. What Chromosome is associated with Prader-Willi/Angelman?

2. If a protein is phosphorylated with Mannose upon leaving the ER, what is its ultimate destination?

3. What is gliosis?

Back 10

1. Chr. 15

2. A lysosome

3. Compensatory proliferation of ASTROCYTES as a consequence of myelin breakdown in MS

Front 11

1. Describe the genetic abnormality of Prader-Willi Syndrome?

2. Diagnose: coarse facial features and lysozymal enzymes in the patients serum?

3. What is the difference between a prophage and a bacteriophage?

Back 11

1. deleted Paternal Chr 15 allele, methylated maternal allele

2. I-cell disease (Inclusion cell)

3. Bacteriophage is a term for a virus; prophage is the lysogenic (latent) incorporation of that virus into the host genome

Front 12

1. Describe the genetic abnormality of Angelman Syndrome?

2. Discuss how/where estrogen is synthesized in women? (HINT: 2 Step/Cell process)

3. What is a Krukenberg tumor?

Back 12

1. deleted Maternal Chr 15 allele, methylated paternal allele

2. LH stimulates testosterone production in thecal cells; testosterone goes to granulosa cells; FSH stimulated conversion of estrogen by Aromatase in granulosa cells

3. Gastric adenocarcinoma metastatic to the ovary

Front 13

1. Draw the adrenal endocrine pathway and INCLUDE alphas and betas!!!

2. What conditions are associated with Ret mutation?

3. Amphetamines cause the release of NE and what else?

Back 13

1. SEE SHEET

2. MEN2a, MEN2b

3. DA! (this contributes to the "reward" feeling

Front 14

1. Hemolytic anemia is associated with disorders of what two metabolic pathways?

2. Warfarin can cause what toxicity?

3. Post-streptococcal glomerulonephritis and IgA nephropathy can both occur post URI. How can you tell the difference between them?

Back 14

1. HMP shunt OR glycolysis

2. skin bullae

3. IgA will have normal complement levels, Post-strep will have lower complement levels

Front 15

1. Compare the levels of p24 Ab and env-Ab in the declining HIV patient?

2. Describe how the mediastinum is divided and give one structure in each part?

3. What drugs are used to treat the hypertensive PREGNANT woman? (2)

Back 15

1. p24 Ab goes down (main Ag of virus production) while env Ab goes slightly up

2. superior (aortic arch)is above sternal notch; below this is anterior (thymus/fat), middle (heart), and posterior (esophagus/aorta)

3. MgSO4 and Methyldopa

Front 16

1. Draw the arteries of the leg?

2. What organs does Reye's syndrome affect? What is the stimulus? What organelle/biochemical process is involved?

3. What condition are Russel Bodies seen in?

Back 16

1. SEE SHEET

2. Virus causes problem with Oxidative Phosphorylation (Mitochondria) in liver and brain

3. Mulitple Myeloma

Front 17

1. What is the platelet threshold for generalized bleeding?

2. Compare the rate of decline in Alzheimers versus Prion disease and what is a primary difference in symtpoms?

3. Where do each of the gonadal veins drain?

Back 17

1. 20,000

2. Alzheimers: very gradual decline, symptoms are cortical function; Prion: quick decline (months) and has motor function problems

3. L drains into the L renal vein, R drains into the IVC

Front 18

1. Which of the Cluster B personality disorders is sexually provacative?

2. Most common type of testicular tumor?

Back 18

1. Histrionic

2. Seminoma Germ Cell