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15 Cards in this Set
- Front
- Back
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Where is the SHH gene produced?
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Base of the limbs in Zone of Polarizing Activity (ZPA)
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What does the SHH gene mediate?
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Ectodermal fxn, patterning along the Ant-Post axis
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What is the SHH gene involved in developing?
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CNS development
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What can mutation of the SHH gene cause?
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Holoprosencephaly
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Where is the Wnt-7 gene produced?
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Apical ectodermal ridge, necessary for proper organization along dorsal-ventral axis
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Where is the FGF gene produced
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Apical ectodermal ridge
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What is the FGF gene required for?
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Mitosis of underlying mesoderm, needed for lengthening of the limbs
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What are the HOX genes needed for?
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Segmental organization of embryo in craniocaudal direction
Error in HOX gene = appendages in the wrong locations |
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What is the highlight of day 0?
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Fertilization by sperm forming zygote
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What is the highlight of Week 1?
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hCG secretion after implantation of blastocyst
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What is the highlight of week 2?
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Bilaminar disc (epiblast, hypoblast)
2 weeks = 2 layers |
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What is the highlight of Week 3?
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Trilaminar disc, gastrulation (formation of trilaminar disc, establishes ecto/meso/endoderms), neural plate begins to form
3 weeks = 3 layers |
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What are the developmental milestones between weeks 3-8?
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Neural tube closes by wek 4
Organogenesis Extremely susceptible to teratogens |
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What are the highlights of Week 4?
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4 heart chambers, heart begins to beat
Upper and lower limb buds begin to form 4 weeks = 4 limbs |
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What is the highlight of Week 8?
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Fetus begins to move, looks like a baby
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