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10 Cards in this Set
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504 EXAM 3 ANTIARRYHYTHMIC DRUGS
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504 EXAM 3 ANTIARRYHYTHMIC DRUGS
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What are the general features of anti-arryhythmic drugs?
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1. single drug, but polypharmacy (a single drug that act on more than one target).
2. low therapeutic index 3. can be proarrhythmic (arrhythmia causing). |
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Class Ia drugs include?
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1. quinidine
2. procainamide 3. disopyramide |
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Mechanism of Class IA
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Blocks Na channels
Increase APC duration due to Class III activity |
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Therapeutic use of Class IA
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Primarily SVTs
Atrial fib and flutter |
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Class IB drugs include?
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1. lidocaine
2. mexiletine |
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Mechanism of Class IB drugs
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Block Na channels
Shorten AP duration |
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Therapeutic uses of Class IB drugs
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Ventricular arrhythmias
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Class IC drugs
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1. propafenone
2. flecanide 3. moricizine |
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Class IC mechanism
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Blocks Na channels
Little effect on AP duration |
