• Shuffle
    Toggle On
    Toggle Off
  • Alphabetize
    Toggle On
    Toggle Off
  • Front First
    Toggle On
    Toggle Off
  • Both Sides
    Toggle On
    Toggle Off
  • Read
    Toggle On
    Toggle Off
Reading...
Front

Card Range To Study

through

image

Play button

image

Play button

image

Progress

1/197

Click to flip

Use LEFT and RIGHT arrow keys to navigate between flashcards;

Use UP and DOWN arrow keys to flip the card;

H to show hint;

A reads text to speech;

197 Cards in this Set

  • Front
  • Back

first line treatment for anaphylaxis with intact airway

subcutaneous epinephrine

what should you do with a positive fingerstick lead level?

recheck with serum lead level since the fingersticks have a high false positive rate

acute iron intoxication stages...

1. GI upset/disturbance
2. shock, metabolic acidosis
3. hepatic failure
4. bowel obstruction from GI scarring
what symptoms do opoid overdoses have that benzos do not?
respiratory depression and pupillary constriction
treatment for Torsades rhythm
discontinue offending agent and give MgSO4
when should you do the first acetominophen level with an overdose?
4 hours after ingestion
when must N-acetylcysteine be given with an acetominophen overdose?
within 8 hours of ingestion
what is lye?
cleaning solution made of sodium hydroxide
what test is indicated for ingestion of strong alkaline solution and why?
upper GI imaging and endoscopy looking for perforation due to the near-instanteous liquifactive necrosis of the esophagus
treatment for diphenhydramine and why
treat with physostigmine to reverse the anti-cholinergic effects
treatment for organophosphate intoxication
remove clothes and wash skin to prevent further absorption, then give atropine
symptoms of opoid withdrawal
N/V, abdominal pain, diarrhea, restlessness, arthralgias, myalgias
symptoms of beta-blocker overdose
AV block, bradycardia, hypotension, wheezing, cardiogenic shock
treatment for beta-blocker overdose

give atropine and fluids first, then glucagon if refractory

how does ethylene glycol affect calcium levels and the kidneys?
associated with hypocalcemia and calcium oxalate deposits in the kidneys
treatment for ethylene glycol intoxication
treat with fomepizole or ethanol
typical EKG finding with TCA toxicity
widened QRS
treatment for widened QRS and why
give sodium bicarbonate to increase extracellular sodium
treatment for PCP intoxication
treat with urine acidification to increase clearance and haloperidol for psychotic symptoms
how will iron pills appear on x-ray?
radio-opaque
first treatment for chemical splash to eye
wash eye for 15 minutes first
what class of drug is fluphenazine? what dangerous side-effect can it have?
high-potency typical antipsychotic; can cause hypothermia due to disruption of thermoregulation and inhibition of shivering mechanism
MC foodborne bacterial infection of the GI tract
salmonella
Rx for rectal fistula
fistulotomy
what disease is a/w hampton's hump on x ray
Pulmonary Embolism
Study design a/w:identifies diseased group and healthy group and retrospectively compares them
case control
Study design a/w:weakened by recall and selection bias
case control
Study design a/w:seeks to estimate disease prevalence and exposure across the population
cross sectional
Study design a/w:examines a collection of studies on a given subject
meta analysis
Study design a/w:prospective blinded study involving placebos, existing therapies and expiramental interventions
random clinical trial
Study design a/w:focuses on one group with a shared exposure or disease and either prospectively or retrospectively compares them
cohort
Study design a/w:examines a collection of cases and seeks insight into the disease of interest
case series
Study design a/w:most useful in a rare disease
case series
Bias a/w:memory errors produce incorrect data
recall bias
Bias a/w:subject awareness of being studied alters their answers and behaviors from normal
observational (or Hawthorne) bias
Bias a/w:certain medical studies attract subject with a particular medical history rather than general population
self-selection bias
Bias a/w:studies that show a difference are preferably published and then later included in a meta analysis rather than studies that support the null hypothesis
publication bias
Bias a/w:screening tests designed ti detect asymptomatic disease may miss rapidly progressive disease because the interval between successive screenings only detect slowly progressing ones
length bias
Bias a/w:screening test may allow earlier diagnosis of the disease but does not translate into actual length of survival
lead-time bias
Bias a/w:subjective interpretation of data by the investigator deviates toward "desired" conclusion
Investigator/Interviewer (or Pygmalion) bias
what does an odds ratio estimate in the case of a disease with a low prevalence
relative risk
anti HTN used in:pt's with no comorbidities
thiazides
anti HTN used in:pt's with diabetes
ACEIs/ARBs
anti HTN used in:pt's with heart failure (multiple answers)
ACEIs/ARBs B-BlockersAldosterone antagonist
anti HTN used in:pt's with BPH
a-Blockers (e.g. Terazosin)
anti HTN used in:pt's with left ventricular hypertrophy
ACEIs/ARBs
anti HTN used in:pt's with hyperthyroid
B-Blockers (e.g. Propranolol)
anti HTN used in:pt's with osteoporosis
thiazides
anti HTN used in:pt's with benign essential tremor
B-Blockers (e.g. Propranolol)
anti HTN used in:pt's with post menopausal female
thiazides
anti HTN used in:pt's with migraines
B-BlockersCCB's
4 signs and symptoms of streptococcal pharyngitis
fevertonsilar exudatetender anterior cervical lymphadenopathylack of rhinorrhea/cough
imaging studies used in a trauma series
AP chest/pelvisAP/lateral C-spineAP Pelvis+ FAST ultrasound
what is the fundamental difference between all of the "risk" equations and the "odds" equations
"RISK" takes an exposure/risk factor and then determines likelihood of developing disease based on that exposure (i.e. cohort study/prospective calculation)"ODDS" takes a disease state (or lack of disease state) and then determines likelihood that there has been a previous exposure (i.e. case-control/retrospective calculation)
equation for risk; what does it tell us
R of exposed group = a/(a+b)R of unexposed group = c/(c+d)RISK OF GETTING DISEASE:"risk" is a PERCENTAGE (i.e. part / total); it tells us what percentage people will get disease if exposed (or unexposed)
equation for relative risk; what does it tell us
RR = risk of exposed/ risk of unexposedRR = [a/(a+b)] / [c/(c+d)]"relative risk" is a PROPORTION; it is a "relative" comparison of "risk" b/w 2 groups (e.g. exposed vs unexposed)
what does it mean when RR = 1RR > 1RR < 1
RR = 1: no relationship (b/w RF & Ds)RR > 1: positive relationship (b/w RF & Ds)RR < 1: negative relationship (b/w RF & Ds)
equation for attributable risk; what does it tell us
AR = risk of exposed - risk of unexposedAR = [a/(a+b)] - [c/(c+d)]
equation for odds; what does it tell us
Odds (Ds'd group) = a:c = a/cOdds (Ds-free group) = b:d = b/cODDS OF PREVIOUS EXPOSURE:"odds" is a RATIO that tells us "LIKELIHOOD" of PREVIOUS EXPOSURE WITHIN a particular group (e.g. ds'd or ds-free)
equation for odds ratio; what does it tell us
OR = (a/b) / (c/d) = (a/c) / (b/d) = ad / bc (simplest to memorize)"odds ratio" is a ratio of ratios; it tells us "INCREASED LIKELIHOOD" of PREVIOUS EXPOSURE of 1 group (i.e. ds'd) RELATIVE to another group (i.e. ds-free)
calculate odds for ds'd & ds-free groups;calculate odds ratioEXAMPLE:10 cancer pt's: 8 previously smoked10 cancer-free pt's (control grp): 2 previously smoked
ODDS:cancer pt's: 8:2 odds of previous exposurecancer-free pt's: 1:9 odds of previous exposureODDS RATIO:cancer odds : cancer-free odds = (8/2)/(1/9) = 36 ==> cancer pt's are 36x MORE LIKELY to have been smokers THAN cancer-free pt's
when is odds ratio a good approximation of relative risk
low prevalence (e.g. rare disease)
What % corresponds to 1, 2, & 3 standard deviation
1 STANDARD DEVIATION: 68%2 STANDARD DEVIATIONS: 95%3 STANDARD DEVIATIONS: 99.7%
what is most important for screening tests
high sensitivity
what is most important for confirmatory tests
high specificiity
What are the equations for Sn & SP
Sn = a / (a + c)Sp = d / (d + b)
What are the equations for (1 - Sn) & (1 - Sp)
(1 - Sn) = c / (a + c)(1 - Sp) = b / (d + b)PROOF: (1 - Sn) = 1 - [a/ (a + c) ]h/w 1 can be re-written as (a + c) / (a + c)[(a + c) / (a + c)] - [a / (a + c)]= (a + c - a) / (a + c)= c / (a + c)PROOF: (1 - Sp) = 1 - [d/ (d + b) ]h/w 1 can be re-written as (d + b) / (d + b)[(d + b) / (d + b)] - [d / (d + b)]= (d + b - d) / (d + b)= b / (d + b)
What are the equations for NPV & PPV
NPV = d / (d + c)PPV = a / (a + b)
equation for absolute risk reduction; what does it tell us
ARR = # of lives saved / # of pt's tx'dARR gives us a percentage of lives saved per ONE pt tx'd
equation for number needed to tx (NNT); what does it tell us
ARR = # of lives saved / # of pt's tx'dNNT = 1 / ARRNNT tells us how many pt's must be treated in order to save ONE life; alternatively the formula can be re-written: 1life saved = NNT x ARR
What are the equations for the Positive Likelihood Ratio (PLR) & the Negative Likelihood Ratio (NLR)
PLR = Sn / (1 - Sp) = [a / (a +c)] / [b / (b + d)]NLR = (1 - Sn) /Sp = [c / (a +c)] / [d / (b + d)]
types of error:list all
Null hypothesis (H0) = TN's = dAlternate hypothesis (H1) = TP's = aType I (alpha) = FP's = bType II (beta) = FN's = c
types of error:accepting the null hypothesis when an association does exist
Type II error (beta) --> "free the guilty"
types of error:rejecting the null hypothesis when no association exists
Type I error (alpha) --> "convict the innocent"
Rx for guilain barre
supportive careplasmaphoresis and IVIG(NO steroids)
what is the cause of chest pain in a young patient that has angina at rest with an ST segment elevation but normal cardiac enzymes
prinzmetal's angina
what infection can cause diarrhea and pseudoappendicitis
Yersinia Enerocolitica
what if parents are refusing clearly life saving treatment for their child
emergency = do it anywaynon emergency = get court order
what circumstance can confidentiality be broken
pt permissionsuicidal/homicidalchild/elder abuse (obligated)penetrating assault woundsreportable diseases
4 elements for malpractice claim
duty to care(legal obligation to conform to standard of care)breach of duty(failure to conform to standard of care)harm(pt was injured/harmed)causation(breach of standard of care was cause of injury/harm)

what are the two ways to establish standard of care in a malpractive case

expert testimonyit speaks for itself ("Res Ipsa Loquitur")
Why can a heavily intoxicated pt refusing medical intervention be temporarily tx'd against his/her will
An intoxicated pt lacks capacity to make medical decisions, including refusal of care
Acetaminophen OD
N-acetylcysteine
Acid or alkali ingestion tx
EGD to eval for stricture
Anticholinesterase or organophosphate OD
Atropine & pralidoxime
Anticholinergic OD
Physostigmine
Arsenic OD
Succimer or dimercaprol
Acetaminophen OD
N-acetylcysteine
Acid or alkali ingestion tx
EGD to eval for stricture
Anticholinesterase or organophosphate OD
Atropine & pralidoxime
Anticholinergic OD
Physostigmine
Arsenic OD
Succimer or dimercaprol
Mercury OD

SucciMER, diMERcaprol

Gold OD
succimer, dimercaprol, penicillamine
BBlocker OD
Glucagon
Phenobarb OD
Urine alkalinization (acetazol, citrate)DialysisActivated charcoal

Benzo OD

Flumazenil if recent, non-dependent

Mercury OD
SucciMER, diMERcaprol
Gold OD
succimer, dimercaprol
BBlocker OD
Glucagon
Phenobarb OD
Urine alkalinization, Dialysis, Activated charcoal
Black widow bite

Ca gluconate, methocarbamol

Carbon monoxide
O2, hyperbaric O2
Copper tx
Penicillamine
lead tx
succimerEDTAdimercaprolpenicillamine
cyanide tx
sodium nitrate, amyl nitrate, sodium thiosulfate
digialis tx
anti-dig Fab, normalize K, lidocaine for torsades
heparin tx
protamine sulfate
iron tx
deferroxamine
isoniazid tx (INH)
vit B6 (pyridoxine)
methanol tx
fomepizole, etoh, dialysis
ethylene glycol (antifreeze) tx
fomepizole, etoh, dialysis, ca gluconate
methemoglobin
methylene blue
opiod OD
naloxone
PCP (phencyclidine hydrochloride)
NG suction
salicylate OD
alkalinize urine (acetazol, citrate)dialysisactivated charcoal
TCA OD
sodium bicarb for QRS prolongLorazepam for szCardiac monitor
Theophylline
activated charcoal, repeat

tpa, streptokinase

aminocaproic acid

warfarin tx

vit K FFP

How to measure incidence.
Cohort
define prevalence
number/proportion of cases in the population at a specific moment in time
define incidence
number of new cases that arise in the disease free population over a period of time
if mortality of a disease decreases, what happens to prevalence?
increased prevalence
Population is measured for prevalence of the disease at a specific point in time. What type of study?
cross-sectional study (aka prevalence study)
Study which compares one diagnostic test to the gold-standard?
cross-sectional study (aka prevalence study)
calculate sensitivity
true positives divided by total with disease (a/a+c)
calculate specificity
true negatives divided by total without disease (d/d+b)
How to remember how to get sensitivty and specificity off a 2x2 chart?
sE is before sP in alphabet, so sEnsitivity is left column and sPecificity is right column
SPIn
positive test in a specific test rules in the disease
SnNOut
negative test in a sensitive test rules out the disease
calculate Positive predictive value (PPV)
true positives divided by total positive results (a/a+b)
calculate Negative predicitve value (NPV)
true negatives divided by total negative results (d/d+c)
how to organize a 2x2 table
outcome/disease is always on top
when do you want a highly sensitive test?
when you want to screen for a disease to rule it out (usually more false positives)
low disease prevalence means what for PPV and NPV?
PPV goes down and NPV goes up
testing someone who has risk factors means what for PPV?
PPV goes up (higher pre-test odds)
calculate positive likelihood ratio (+LR); remember it's a ratio of likelihoods
true positive probability/false positive probability (sens/1-spec)
calculate negative likelihood ratio (-LR); remember it's a ratio of likelihoods
false negative probability/true negative probability (1-sens/spec)
how to remember how to calculate Likelihood Ratio? (where do you put the diseased population?)
truly diseased population always goes on top of the calculation: for +LR, true positives are on top, for -LR, false negatives are on top
when are exposures and outcomes in a prospective cohort study?
exposure in the future, outcome further in the future
when are exposures and outcomes in a retrospective cohort study?
exposure in the past, outcome in the more recent past
define the population of study in a cohort study
those who don't have the outcome but who could all potentially experience that outcome
define the population of study in a case control study
those who have the outcome presently
Cheapest type of study.
cross sectional study
when are exposures and outcomes in a case control study?
study group is defined by presence of outcome; exposures are measured (past or present)
Cohort study: what is measured?
cOhort measures Outcomes in a group with similar exposures
Case control study: what is measured?
casE control measures Exposures in a group with similar outcomes
Case Control studies cannot measure risk. Instead they measure what?
Odds Ratio: how much more likely it is for a person with outcome is to have an exposure than a person without an outcome
Define Absolute Risk (AR)
incidence of outcome
Define Relative Risk (RR)
incidence of outcome in exposed/incidence of outcome in unexposed
Define Attributable Risk (aka Absolute Risk Reduction or ARR)
incidence of outcome in exposed - incidence of outcome in unexposed
Define Relative Risk Reduction (RRR)
1-RR
Define Odds Ratio (OR)
odds of exposure in person with outcome/odds of exposure in person without outcome
Calculate Odds based on Probability
Odds = probability of event/1-probability of event
Calculate Probability based on Odds
Probability = Odds/1+Odds
Surgeon only operates on patients without significant comorbid conditions, then reports outcomes are better than other surgeons. What bias?
selection bias
Data gathered from 5 hospitals about stroke. One of the hospitals doesn't have MRI, so they use data from CT scans. What bias?
measurement bias
Study finds that construction workers who work 60 hours or more per week are more likely to have skin cancer. They conclude being over-worked causes skin cancer. What bias?
confounding bias
Patients with diarrhea are asked if they ate a specific food in the last week. Worry about what bias?
recall bias
New screening test claims to improve cancer survival by five years. Later study finds this cancer's average age of onset is earlier. What bias has this screening test created?
lead-time bias
Cancer prognosis is different in 2 hospitals. It is found that they use 2 different screeing test and one fails to catch the cancers with poor prognosis. What bias?
length bias
Type 1 (alpha) error vs Type 2 (beta) error: how to remember?
Type 1: rejects the nullType 2: don't reject null (remember TWO is a DOUBLE negative)
Define p value
probability that the differences found in the study occurred by chance
How to increase Power in a study.
increase number of subjects
How to decrease the Confidence Interval in a study?
increase number of subjects

Conclusion of insignificant difference based on confidence interval? (2)

it crosses 1 on plot of RR or Oddsit crosses 0 on plot of ARR
Bias introduced into a study when a clinician is aware of the patient's treatment type.
Observational bias
Bias introduced when screening detects a disease earlier & thus lengthens the time from diagnosis to death.
Lead-time bias
If you want to know if race affects infant mortality rate but most of the variation in infant mortality is predicted by socioeconomic status, then socioeconomic status is a ____.
confounding variable
The number of true positives divided by the number of patients w/ the disease is ____.
sensitivity
Sensitive tests have few false negatives & are used to rule ____ a disease.
OUT
PPD reactivity is used as a screening test because most people w/ TB (except those who are anergic) will have a (+)PPD. Highly sensistive or specific?
highly SENSITIVE for TB
Chronic diseases such as SLE -- higher prevalence or incidence?
higher PREVALENCE
Epidemics such as influenza -- higher prevalence or incidence?
higher INCIDENCE
Cross-sectional survey --incidence or prevalence?
PREVALENCE
Cohort study -- incidence or prevalence?
incidence AND prevalence
Case-control study -- incidence or prevalence?
Neither
Describe a test that consistently gives identical results, but the results are wrong.
high reliability, low validity
Difference between a cohort & a case-control study.
COHORT studies can be used to calculate relative risk (RR), incidence, and/or odds ratio (OR). CASE-CONTROL studies can be used to calculate (only?) an odds ratio (OR).
Attributable risk?
[the incidence rate (IR) of a disease in exposed] - [the IR of a disease UNexposed]
Relative risk?
[the incidence ratio (IR) of a disease in a population exposed TO A PARTICULAR FACTOR] / [the IR of those not exposed]
Odds ratio (OR)?
The liklihood of a disease among individuals exposed to a risk factor compared to those who have NOT been exposed
Number needed to treat (NNT)?
1 / [rate in UNtreated - rate in treated group]
In which patients do you initiate colorectal cancer screening early?
Patients who have either ...IBD FAP/HNPCC;1st-degree relatives w/ adenomatous polyps (<60 y/o), or colorectal cancer
The most common cancer in men & the most common cause of death from cancer in men.
PROSTATE cancer is the most common cancer in men, but LUNG cancer causes more (the most) deaths
The percentage of cases within ONE standard deviation (SD) from the mean?TWO SDs?THREE SDs?
1 SD = 68.0%2 SD = 95.5%3 SD = 99.7%
Birth rate?
Number of live births per 1000 population
Fertility rate?
Number of live births per 1000 WOMEN 15-44 YEARS OF AGE
Mortality rate?
Number of deaths per 1000 population
NEONATAL mortality rate?

Number of deaths from *BIRTH - 28 DAYS* per 1000 LIVE births

POSTNATAL mortality rate?
Number of deaths from *28 DAYS - 1 YEAR* per 1000 LIVE births
INFANT mortality rate?
Number of deaths from *BIRTH - 1 YEAR* per 1000 LIVE births(neonatal mortality + postnatal mortality)
FETAL mortality rate?

Number of deaths from *20 WEEKS GESTATION - BIRTH* per 1000 TOTAL births

PERINATAL mortality rate?
Number of deaths from *20 WEEKS GESTATION - 1 MONTH OF LIFE* per 1000 TOTAL births
MATERNAL mortality rate?

Number of deaths *DURING PREGNANCY - 90 DAYS POSTPARTUM* per 100 000 LIVE births

X (type) mortality rate = number of deaths from [A - B] timeframe per 1000 [LIVE, TOTAL] deaths(neonatal, postnatal, infant, fetal, perinatal, maternal)

NEONATAL: birth - 28 days (live) POSTNATAL: 28 days - 1 year (live) INFANT: birth - 1 year (live) FETAL: 20 weeks' gestation - birth (total) PERINATAL: 20 weeks' gestation - 1 month of life (total) MATERNAL: during pregnancy - 90 days postpartum (live)