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197 Cards in this Set
- Front
- Back
first line treatment for anaphylaxis with intact airway |
subcutaneous epinephrine
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what should you do with a positive fingerstick lead level? |
recheck with serum lead level since the fingersticks have a high false positive rate
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acute iron intoxication stages... |
1. GI upset/disturbance
2. shock, metabolic acidosis 3. hepatic failure 4. bowel obstruction from GI scarring |
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what symptoms do opoid overdoses have that benzos do not?
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respiratory depression and pupillary constriction
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treatment for Torsades rhythm
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discontinue offending agent and give MgSO4
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when should you do the first acetominophen level with an overdose?
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4 hours after ingestion
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when must N-acetylcysteine be given with an acetominophen overdose?
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within 8 hours of ingestion
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what is lye?
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cleaning solution made of sodium hydroxide
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what test is indicated for ingestion of strong alkaline solution and why?
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upper GI imaging and endoscopy looking for perforation due to the near-instanteous liquifactive necrosis of the esophagus
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treatment for diphenhydramine and why
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treat with physostigmine to reverse the anti-cholinergic effects
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treatment for organophosphate intoxication
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remove clothes and wash skin to prevent further absorption, then give atropine
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symptoms of opoid withdrawal
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N/V, abdominal pain, diarrhea, restlessness, arthralgias, myalgias
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symptoms of beta-blocker overdose
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AV block, bradycardia, hypotension, wheezing, cardiogenic shock
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treatment for beta-blocker overdose
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give atropine and fluids first, then glucagon if refractory |
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how does ethylene glycol affect calcium levels and the kidneys?
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associated with hypocalcemia and calcium oxalate deposits in the kidneys
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treatment for ethylene glycol intoxication
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treat with fomepizole or ethanol
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typical EKG finding with TCA toxicity
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widened QRS
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treatment for widened QRS and why
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give sodium bicarbonate to increase extracellular sodium
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treatment for PCP intoxication
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treat with urine acidification to increase clearance and haloperidol for psychotic symptoms
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how will iron pills appear on x-ray?
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radio-opaque
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first treatment for chemical splash to eye
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wash eye for 15 minutes first
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what class of drug is fluphenazine? what dangerous side-effect can it have?
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high-potency typical antipsychotic; can cause hypothermia due to disruption of thermoregulation and inhibition of shivering mechanism
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MC foodborne bacterial infection of the GI tract
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salmonella
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Rx for rectal fistula
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fistulotomy
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what disease is a/w hampton's hump on x ray
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Pulmonary Embolism
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Study design a/w:identifies diseased group and healthy group and retrospectively compares them
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case control
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Study design a/w:weakened by recall and selection bias
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case control
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Study design a/w:seeks to estimate disease prevalence and exposure across the population
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cross sectional
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Study design a/w:examines a collection of studies on a given subject
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meta analysis
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Study design a/w:prospective blinded study involving placebos, existing therapies and expiramental interventions
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random clinical trial
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Study design a/w:focuses on one group with a shared exposure or disease and either prospectively or retrospectively compares them
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cohort
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Study design a/w:examines a collection of cases and seeks insight into the disease of interest
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case series
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Study design a/w:most useful in a rare disease
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case series
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Bias a/w:memory errors produce incorrect data
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recall bias
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Bias a/w:subject awareness of being studied alters their answers and behaviors from normal
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observational (or Hawthorne) bias
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Bias a/w:certain medical studies attract subject with a particular medical history rather than general population
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self-selection bias
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Bias a/w:studies that show a difference are preferably published and then later included in a meta analysis rather than studies that support the null hypothesis
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publication bias
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Bias a/w:screening tests designed ti detect asymptomatic disease may miss rapidly progressive disease because the interval between successive screenings only detect slowly progressing ones
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length bias
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Bias a/w:screening test may allow earlier diagnosis of the disease but does not translate into actual length of survival
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lead-time bias
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Bias a/w:subjective interpretation of data by the investigator deviates toward "desired" conclusion
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Investigator/Interviewer (or Pygmalion) bias
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what does an odds ratio estimate in the case of a disease with a low prevalence
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relative risk
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anti HTN used in:pt's with no comorbidities
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thiazides
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anti HTN used in:pt's with diabetes
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ACEIs/ARBs
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anti HTN used in:pt's with heart failure (multiple answers)
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ACEIs/ARBs B-BlockersAldosterone antagonist
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anti HTN used in:pt's with BPH
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a-Blockers (e.g. Terazosin)
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anti HTN used in:pt's with left ventricular hypertrophy
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ACEIs/ARBs
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anti HTN used in:pt's with hyperthyroid
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B-Blockers (e.g. Propranolol)
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anti HTN used in:pt's with osteoporosis
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thiazides
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anti HTN used in:pt's with benign essential tremor
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B-Blockers (e.g. Propranolol)
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anti HTN used in:pt's with post menopausal female
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thiazides
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anti HTN used in:pt's with migraines
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B-BlockersCCB's
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4 signs and symptoms of streptococcal pharyngitis
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fevertonsilar exudatetender anterior cervical lymphadenopathylack of rhinorrhea/cough
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imaging studies used in a trauma series
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AP chest/pelvisAP/lateral C-spineAP Pelvis+ FAST ultrasound
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what is the fundamental difference between all of the "risk" equations and the "odds" equations
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"RISK" takes an exposure/risk factor and then determines likelihood of developing disease based on that exposure (i.e. cohort study/prospective calculation)"ODDS" takes a disease state (or lack of disease state) and then determines likelihood that there has been a previous exposure (i.e. case-control/retrospective calculation)
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equation for risk; what does it tell us
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R of exposed group = a/(a+b)R of unexposed group = c/(c+d)RISK OF GETTING DISEASE:"risk" is a PERCENTAGE (i.e. part / total); it tells us what percentage people will get disease if exposed (or unexposed)
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equation for relative risk; what does it tell us
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RR = risk of exposed/ risk of unexposedRR = [a/(a+b)] / [c/(c+d)]"relative risk" is a PROPORTION; it is a "relative" comparison of "risk" b/w 2 groups (e.g. exposed vs unexposed)
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what does it mean when RR = 1RR > 1RR < 1
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RR = 1: no relationship (b/w RF & Ds)RR > 1: positive relationship (b/w RF & Ds)RR < 1: negative relationship (b/w RF & Ds)
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equation for attributable risk; what does it tell us
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AR = risk of exposed - risk of unexposedAR = [a/(a+b)] - [c/(c+d)]
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equation for odds; what does it tell us
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Odds (Ds'd group) = a:c = a/cOdds (Ds-free group) = b:d = b/cODDS OF PREVIOUS EXPOSURE:"odds" is a RATIO that tells us "LIKELIHOOD" of PREVIOUS EXPOSURE WITHIN a particular group (e.g. ds'd or ds-free)
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equation for odds ratio; what does it tell us
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OR = (a/b) / (c/d) = (a/c) / (b/d) = ad / bc (simplest to memorize)"odds ratio" is a ratio of ratios; it tells us "INCREASED LIKELIHOOD" of PREVIOUS EXPOSURE of 1 group (i.e. ds'd) RELATIVE to another group (i.e. ds-free)
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calculate odds for ds'd & ds-free groups;calculate odds ratioEXAMPLE:10 cancer pt's: 8 previously smoked10 cancer-free pt's (control grp): 2 previously smoked
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ODDS:cancer pt's: 8:2 odds of previous exposurecancer-free pt's: 1:9 odds of previous exposureODDS RATIO:cancer odds : cancer-free odds = (8/2)/(1/9) = 36 ==> cancer pt's are 36x MORE LIKELY to have been smokers THAN cancer-free pt's
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when is odds ratio a good approximation of relative risk
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low prevalence (e.g. rare disease)
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What % corresponds to 1, 2, & 3 standard deviation
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1 STANDARD DEVIATION: 68%2 STANDARD DEVIATIONS: 95%3 STANDARD DEVIATIONS: 99.7%
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what is most important for screening tests
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high sensitivity
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what is most important for confirmatory tests
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high specificiity
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What are the equations for Sn & SP
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Sn = a / (a + c)Sp = d / (d + b)
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What are the equations for (1 - Sn) & (1 - Sp)
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(1 - Sn) = c / (a + c)(1 - Sp) = b / (d + b)PROOF: (1 - Sn) = 1 - [a/ (a + c) ]h/w 1 can be re-written as (a + c) / (a + c)[(a + c) / (a + c)] - [a / (a + c)]= (a + c - a) / (a + c)= c / (a + c)PROOF: (1 - Sp) = 1 - [d/ (d + b) ]h/w 1 can be re-written as (d + b) / (d + b)[(d + b) / (d + b)] - [d / (d + b)]= (d + b - d) / (d + b)= b / (d + b)
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What are the equations for NPV & PPV
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NPV = d / (d + c)PPV = a / (a + b)
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equation for absolute risk reduction; what does it tell us
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ARR = # of lives saved / # of pt's tx'dARR gives us a percentage of lives saved per ONE pt tx'd
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equation for number needed to tx (NNT); what does it tell us
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ARR = # of lives saved / # of pt's tx'dNNT = 1 / ARRNNT tells us how many pt's must be treated in order to save ONE life; alternatively the formula can be re-written: 1life saved = NNT x ARR
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What are the equations for the Positive Likelihood Ratio (PLR) & the Negative Likelihood Ratio (NLR)
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PLR = Sn / (1 - Sp) = [a / (a +c)] / [b / (b + d)]NLR = (1 - Sn) /Sp = [c / (a +c)] / [d / (b + d)]
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types of error:list all
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Null hypothesis (H0) = TN's = dAlternate hypothesis (H1) = TP's = aType I (alpha) = FP's = bType II (beta) = FN's = c
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types of error:accepting the null hypothesis when an association does exist
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Type II error (beta) --> "free the guilty"
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types of error:rejecting the null hypothesis when no association exists
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Type I error (alpha) --> "convict the innocent"
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Rx for guilain barre
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supportive careplasmaphoresis and IVIG(NO steroids)
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what is the cause of chest pain in a young patient that has angina at rest with an ST segment elevation but normal cardiac enzymes
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prinzmetal's angina
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what infection can cause diarrhea and pseudoappendicitis
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Yersinia Enerocolitica
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what if parents are refusing clearly life saving treatment for their child
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emergency = do it anywaynon emergency = get court order
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what circumstance can confidentiality be broken
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pt permissionsuicidal/homicidalchild/elder abuse (obligated)penetrating assault woundsreportable diseases
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4 elements for malpractice claim
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duty to care(legal obligation to conform to standard of care)breach of duty(failure to conform to standard of care)harm(pt was injured/harmed)causation(breach of standard of care was cause of injury/harm)
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what are the two ways to establish standard of care in a malpractive case |
expert testimonyit speaks for itself ("Res Ipsa Loquitur")
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Why can a heavily intoxicated pt refusing medical intervention be temporarily tx'd against his/her will
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An intoxicated pt lacks capacity to make medical decisions, including refusal of care
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Acetaminophen OD
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N-acetylcysteine
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Acid or alkali ingestion tx
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EGD to eval for stricture
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Anticholinesterase or organophosphate OD
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Atropine & pralidoxime
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Anticholinergic OD
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Physostigmine
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Arsenic OD
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Succimer or dimercaprol
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Acetaminophen OD
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N-acetylcysteine
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Acid or alkali ingestion tx
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EGD to eval for stricture
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Anticholinesterase or organophosphate OD
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Atropine & pralidoxime
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Anticholinergic OD
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Physostigmine
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Arsenic OD
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Succimer or dimercaprol
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Mercury OD
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SucciMER, diMERcaprol |
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Gold OD
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succimer, dimercaprol, penicillamine
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BBlocker OD
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Glucagon
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Phenobarb OD
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Urine alkalinization (acetazol, citrate)DialysisActivated charcoal
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Benzo OD |
Flumazenil if recent, non-dependent |
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Mercury OD
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SucciMER, diMERcaprol
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Gold OD
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succimer, dimercaprol
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BBlocker OD
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Glucagon
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Phenobarb OD
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Urine alkalinization, Dialysis, Activated charcoal
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Black widow bite
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Ca gluconate, methocarbamol |
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Carbon monoxide
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O2, hyperbaric O2
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Copper tx
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Penicillamine
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lead tx
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succimerEDTAdimercaprolpenicillamine
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cyanide tx
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sodium nitrate, amyl nitrate, sodium thiosulfate
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digialis tx
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anti-dig Fab, normalize K, lidocaine for torsades
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heparin tx
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protamine sulfate
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iron tx
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deferroxamine
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isoniazid tx (INH)
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vit B6 (pyridoxine)
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methanol tx
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fomepizole, etoh, dialysis
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ethylene glycol (antifreeze) tx
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fomepizole, etoh, dialysis, ca gluconate
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methemoglobin
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methylene blue
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opiod OD
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naloxone
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PCP (phencyclidine hydrochloride)
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NG suction
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salicylate OD
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alkalinize urine (acetazol, citrate)dialysisactivated charcoal
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TCA OD
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sodium bicarb for QRS prolongLorazepam for szCardiac monitor
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Theophylline
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activated charcoal, repeat
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tpa, streptokinase |
aminocaproic acid
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warfarin tx |
vit K FFP |
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How to measure incidence.
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Cohort
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define prevalence
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number/proportion of cases in the population at a specific moment in time
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define incidence
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number of new cases that arise in the disease free population over a period of time
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if mortality of a disease decreases, what happens to prevalence?
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increased prevalence
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Population is measured for prevalence of the disease at a specific point in time. What type of study?
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cross-sectional study (aka prevalence study)
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Study which compares one diagnostic test to the gold-standard?
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cross-sectional study (aka prevalence study)
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calculate sensitivity
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true positives divided by total with disease (a/a+c)
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calculate specificity
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true negatives divided by total without disease (d/d+b)
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How to remember how to get sensitivty and specificity off a 2x2 chart?
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sE is before sP in alphabet, so sEnsitivity is left column and sPecificity is right column
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SPIn
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positive test in a specific test rules in the disease
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SnNOut
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negative test in a sensitive test rules out the disease
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calculate Positive predictive value (PPV)
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true positives divided by total positive results (a/a+b)
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calculate Negative predicitve value (NPV)
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true negatives divided by total negative results (d/d+c)
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how to organize a 2x2 table
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outcome/disease is always on top
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when do you want a highly sensitive test?
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when you want to screen for a disease to rule it out (usually more false positives)
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low disease prevalence means what for PPV and NPV?
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PPV goes down and NPV goes up
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testing someone who has risk factors means what for PPV?
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PPV goes up (higher pre-test odds)
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calculate positive likelihood ratio (+LR); remember it's a ratio of likelihoods
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true positive probability/false positive probability (sens/1-spec)
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calculate negative likelihood ratio (-LR); remember it's a ratio of likelihoods
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false negative probability/true negative probability (1-sens/spec)
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how to remember how to calculate Likelihood Ratio? (where do you put the diseased population?)
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truly diseased population always goes on top of the calculation: for +LR, true positives are on top, for -LR, false negatives are on top
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when are exposures and outcomes in a prospective cohort study?
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exposure in the future, outcome further in the future
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when are exposures and outcomes in a retrospective cohort study?
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exposure in the past, outcome in the more recent past
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define the population of study in a cohort study
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those who don't have the outcome but who could all potentially experience that outcome
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define the population of study in a case control study
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those who have the outcome presently
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Cheapest type of study.
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cross sectional study
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when are exposures and outcomes in a case control study?
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study group is defined by presence of outcome; exposures are measured (past or present)
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Cohort study: what is measured?
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cOhort measures Outcomes in a group with similar exposures
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Case control study: what is measured?
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casE control measures Exposures in a group with similar outcomes
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Case Control studies cannot measure risk. Instead they measure what?
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Odds Ratio: how much more likely it is for a person with outcome is to have an exposure than a person without an outcome
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Define Absolute Risk (AR)
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incidence of outcome
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Define Relative Risk (RR)
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incidence of outcome in exposed/incidence of outcome in unexposed
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Define Attributable Risk (aka Absolute Risk Reduction or ARR)
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incidence of outcome in exposed - incidence of outcome in unexposed
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Define Relative Risk Reduction (RRR)
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1-RR
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Define Odds Ratio (OR)
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odds of exposure in person with outcome/odds of exposure in person without outcome
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Calculate Odds based on Probability
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Odds = probability of event/1-probability of event
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Calculate Probability based on Odds
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Probability = Odds/1+Odds
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Surgeon only operates on patients without significant comorbid conditions, then reports outcomes are better than other surgeons. What bias?
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selection bias
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Data gathered from 5 hospitals about stroke. One of the hospitals doesn't have MRI, so they use data from CT scans. What bias?
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measurement bias
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Study finds that construction workers who work 60 hours or more per week are more likely to have skin cancer. They conclude being over-worked causes skin cancer. What bias?
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confounding bias
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Patients with diarrhea are asked if they ate a specific food in the last week. Worry about what bias?
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recall bias
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New screening test claims to improve cancer survival by five years. Later study finds this cancer's average age of onset is earlier. What bias has this screening test created?
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lead-time bias
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Cancer prognosis is different in 2 hospitals. It is found that they use 2 different screeing test and one fails to catch the cancers with poor prognosis. What bias?
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length bias
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Type 1 (alpha) error vs Type 2 (beta) error: how to remember?
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Type 1: rejects the nullType 2: don't reject null (remember TWO is a DOUBLE negative)
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Define p value
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probability that the differences found in the study occurred by chance
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How to increase Power in a study.
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increase number of subjects
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How to decrease the Confidence Interval in a study?
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increase number of subjects
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Conclusion of insignificant difference based on confidence interval? (2) |
it crosses 1 on plot of RR or Oddsit crosses 0 on plot of ARR
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Bias introduced into a study when a clinician is aware of the patient's treatment type.
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Observational bias
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Bias introduced when screening detects a disease earlier & thus lengthens the time from diagnosis to death.
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Lead-time bias
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If you want to know if race affects infant mortality rate but most of the variation in infant mortality is predicted by socioeconomic status, then socioeconomic status is a ____.
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confounding variable
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The number of true positives divided by the number of patients w/ the disease is ____.
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sensitivity
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Sensitive tests have few false negatives & are used to rule ____ a disease.
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OUT
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PPD reactivity is used as a screening test because most people w/ TB (except those who are anergic) will have a (+)PPD. Highly sensistive or specific?
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highly SENSITIVE for TB
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Chronic diseases such as SLE -- higher prevalence or incidence?
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higher PREVALENCE
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Epidemics such as influenza -- higher prevalence or incidence?
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higher INCIDENCE
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Cross-sectional survey --incidence or prevalence?
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PREVALENCE
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Cohort study -- incidence or prevalence?
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incidence AND prevalence
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Case-control study -- incidence or prevalence?
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Neither
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Describe a test that consistently gives identical results, but the results are wrong.
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high reliability, low validity
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Difference between a cohort & a case-control study.
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COHORT studies can be used to calculate relative risk (RR), incidence, and/or odds ratio (OR). CASE-CONTROL studies can be used to calculate (only?) an odds ratio (OR).
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Attributable risk?
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[the incidence rate (IR) of a disease in exposed] - [the IR of a disease UNexposed]
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Relative risk?
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[the incidence ratio (IR) of a disease in a population exposed TO A PARTICULAR FACTOR] / [the IR of those not exposed]
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Odds ratio (OR)?
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The liklihood of a disease among individuals exposed to a risk factor compared to those who have NOT been exposed
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Number needed to treat (NNT)?
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1 / [rate in UNtreated - rate in treated group]
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In which patients do you initiate colorectal cancer screening early?
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Patients who have either ...IBD FAP/HNPCC;1st-degree relatives w/ adenomatous polyps (<60 y/o), or colorectal cancer
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The most common cancer in men & the most common cause of death from cancer in men.
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PROSTATE cancer is the most common cancer in men, but LUNG cancer causes more (the most) deaths
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The percentage of cases within ONE standard deviation (SD) from the mean?TWO SDs?THREE SDs?
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1 SD = 68.0%2 SD = 95.5%3 SD = 99.7%
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Birth rate?
|
Number of live births per 1000 population
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Fertility rate?
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Number of live births per 1000 WOMEN 15-44 YEARS OF AGE
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Mortality rate?
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Number of deaths per 1000 population
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NEONATAL mortality rate?
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Number of deaths from *BIRTH - 28 DAYS* per 1000 LIVE births |
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POSTNATAL mortality rate?
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Number of deaths from *28 DAYS - 1 YEAR* per 1000 LIVE births
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INFANT mortality rate?
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Number of deaths from *BIRTH - 1 YEAR* per 1000 LIVE births(neonatal mortality + postnatal mortality)
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FETAL mortality rate?
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Number of deaths from *20 WEEKS GESTATION - BIRTH* per 1000 TOTAL births |
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PERINATAL mortality rate?
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Number of deaths from *20 WEEKS GESTATION - 1 MONTH OF LIFE* per 1000 TOTAL births
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MATERNAL mortality rate?
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Number of deaths *DURING PREGNANCY - 90 DAYS POSTPARTUM* per 100 000 LIVE births |
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X (type) mortality rate = number of deaths from [A - B] timeframe per 1000 [LIVE, TOTAL] deaths(neonatal, postnatal, infant, fetal, perinatal, maternal)
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NEONATAL: birth - 28 days (live) POSTNATAL: 28 days - 1 year (live) INFANT: birth - 1 year (live) FETAL: 20 weeks' gestation - birth (total) PERINATAL: 20 weeks' gestation - 1 month of life (total) MATERNAL: during pregnancy - 90 days postpartum (live) |