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23 Cards in this Set
- Front
- Back
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What four criteria are used to assure the quality of analytics? |
The appropriateness of the calibrator, method, performance of method, and results. |
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What is the purpose of calibration? |
To ensure the results obtained by local analysers match reference values |
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How is calibration achieved? |
By examining any discrepancies between the local analysis of a sample with known values |
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The ______ the concentration of a substance, the ______ it is to measure. |
higher; easier and lower; harder |
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What defines the sensitivity of an assay? |
The minimum amount of analyte it can detect |
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What defines the upper limit of an assay? |
The point at which the system fails due to reagent exhaustion, detection system overload, etc. |
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What is the hook effect? |
When high concentrations of an analyte cause the assay system to fail |
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What is a working range? |
The minimum and maximum limit of analyte which can be measured by a particular assay |
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What is a typical working range? |
Anywhere from tenfold to hundredfold range in concentration |
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Does single point or multi point calibration contain more sources of error? |
Multi point calibration |
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When can a single point and a sample blank be used to form a calibration curve? |
When the working range is linear |
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What is a heterogeneous analyte? |
A mixture of related molecules |
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What causes issues when examining heterogeneous analytes? |
Different assays must be used to measure the different elements of the analyte-- these tests can have discrepancies |
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What is traceability? |
An unbroken chain of measurements being compared, leading to a known reference value |
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What is internal quality control? |
Each individual lab assuring that one day's results are comparable to the day before |
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What causes large bias in assay errors? |
Calibration or reagent errors |
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What causes slow drift in assay errors? |
Aging of reagents or equipment |
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What type of assay errors are most prevalent in modern labs? |
Slow drift-- large bias is generally caught quickly, so calibration is used to monitor slow drift and prevent it from eventually impacting test results |
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How is slow drift monitored in most labs? |
Using trend detection techniques |
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How are ICQ assessments completed? |
Results are checked against correct values, graphed, and trends are examined |
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What makes POC test quality control difficult? |
It includes variability due to the technique of operators and the format of assays |
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What is an External Quality Assessment? |
An assessment which ensures that results are comparable between laboratories |
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What is the purpose of laboratory accreditation? |
To make sure lab procedures and standards are in line with legislation and best practice |
