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202 Cards in this Set
- Front
- Back
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cladribine |
adenosine analog hairy cell leukemia nephrotoxi neurotoxic |
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cytarabine |
pyrimidine analygo inhibits dna pancyotopenia throbmocytpenia eglaoblastic anemia |
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5 fluorauracil |
5 f dump covalet folic inhibits thymidylate syntehase meylospuressive with no change with folic acid |
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methotrexate |
folic acid analog inhibit dihydrofolate reductase hepatotoxic mucocitis pulmonary iborosis |
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bleomycin |
free radical pumonary fibrosis pigmentation |
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dactinomycin |
intercalates dna used in child tumors |
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doxorubicin daunorubicin |
free radical decrease DNA cardiotoxic meylosupressive |
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busulfan |
cross link DNA |
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cyclophosphamide ifosfamide |
cross link dna mensa to prevent hemorgaic cystitic |
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nistrourea |
bioactivaiton to incativate dna CNS toxic |
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cisplatin carboplatin |
cross linkdna at g7 neophrotoxic add amifostine |
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etoposide tenoposide |
decrease dna topo II |
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ironetecan topotecna |
decrease DNA topo I |
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hydroxyurea |
decrease ribonucleotide reductease use for sickle cell |
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prednisone |
gene alteration of exrpession |
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bevacizumab |
anti vegf |
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erlotinib |
angit egfr |
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imantinib |
bcrabl and ckit |
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rituximab |
cd 20 |
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tamoxifen raloxifen |
serm |
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trastuzumab |
her 2 |
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vermurafenib |
braf + to target metastic melanoma |
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cyclosporine |
binds to to cyclophilin to inhibit calcinuerin nerphotoxic present il2 transcription |
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tacrolimus |
inhibit calcineruin by binding to rk506 prevent il2 transcriotion |
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sirolimus |
mtor inhibiotr bins to fkbp prevent responds to il2 insulin resitance but no kidney damage works well with cyclosporine |
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daclizumab basiliximab |
monnocolonal ab against il2r |
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azathiorpine |
metatolgine to 6mp block nucelotide degraded by hgprt and toxicity increased by allopruinol |
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glucocorticoids |
inhibit nfkab cushing syndrome risk |
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mycophenolate |
inhibit immp dehrydogenase hyperglycemia hyeprchosltema hypertension |
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thalidomide |
derrease tnf alpha increase nk cells and il2 phocomelia |
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aldesleukin |
il2 renal cell carcinoma metastoci melanoma |
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epo |
anemia in renal failure |
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filgrastim |
gcsf |
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sargramostim |
gmcsf |
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romipostin |
thromocytopenis |
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oprelvekin |
thrombocytopenia |
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albutoeral and bslmoterol |
b2>b1 |
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dobutamine |
beta 1,> beta 2> alpha |
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dopamine |
d1: d2> b> alpha medium dose b 1 b2 high alpha alpha 2 |
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epineprhine |
beta then alpha |
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isoprotenernol |
beta 1 + beta 2 |
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neorpienpherine |
alpha 1 alpha 2 beta |
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phenyelphrinde |
alpha 1 and alpha 2 |
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phenoxyybenzamine |
irrefesrible non selective alpha |
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phetolamine |
revesrible non selective apha |
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prazosin terozoine doxazoin tamsulosin |
alpha 1 selective |
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mirtazapine |
alpha 2 selective |
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nebivolol |
comibinds cardia selective beta 1 with b3 to increase nos |
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cyanide toxiciting |
nitrate thiosulfate hydroxcobolamin |
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beta blocker overdose |
glucagon |
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theophyllline overdose |
beta blocker |
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cuteanous flushing |
vacomycin adenosine niacin ca channel blockers |
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musacrinic atnoglinst |
atropine homatropine torpicamide benztropine clygocpyroolate hyscoamine discyclomine ipratropium tiotropium aoxygebutynin slidfenacin teolterodine scopolamine |
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seizure causing drugs |
isonaizid buproprion impenem and cilastin enfluraine |
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photosensitivit |
sulfonamides ' amiodarone tetarcyclines 5 fu |
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acute mania treatment |
mood stabilizers lithium valproate carbamazepine or atypical antispysch olanzapine |
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gout attacks |
niaicin cyclorpsoine pyrazinamide hydrocholrothiazide |
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niacin |
flushing increase uric acid to preciptate gout increase HDL the most decresae vldl and tg |
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statins |
use for high ldl hepatitis myeotpathy |
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naicin |
low hdl uses cuteanous vasodilation hyerlgycemia hyerpureceima hepattis psotive achtaois nigracans |
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fibric acid derivatives |
high tg uses gall stones mypotathy |
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bilee aciding binding resitns |
high ldl gi upset hypergriglicerdima malabosrption |
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antibiotics for psyedomonas |
antipsuedonoma penicillisn: ticarcillin pipercilling ceftazdime 3rd gen cephalosporine cefepime aminoglyclosides flouroquinoonles azeotrenam carbapenems |
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intracellular organisms |
chlamydia legionalla listera mmycobacterium neissermia meninigit nocardia ricketsi salmonella cyrptococcus neoforams histoplasma penucystitis jifevoci plasmoaium toxoplasmosis |
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motility |
tumbling listeria corkscrew c jejuni |
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nerve constant
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lenght constant is how much impulse can travel before decreases in amplitude threshold is how much required to instiate ap summaiton is how much mutiple postsynaptic postentisls on target nuerons temporal is sequetional where spatial is many different impules into one time constant how much time it takes for nerve to get back itscharge. |
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pentazocine |
partial agonist weak antgonist at mu will preciptate opiod withdrawl if used in combo with morphine or other mu |
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vagus nerve is |
releases ach and produces muscarinic repsonses |
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dress syndrome |
drug reaction with esonpiha and ysstemid sytpmos afer new meds 2-8 weeks post drug seen in anticonvulsants, allopurinoal suflmaonmides antibiotics liek vanco and minicycline drug induces herpes reactivaiton followed by expantion fo t cells that cross wtih drug seen fever generalized lymphadeapthy and faial edema and diffuse skin rash that can be ertheamousa nd follicular high eosinophila |
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actinic kertaosis |
erythematous papules overlying whitsihc scale more often felst than seen with sand paper like texutre can be come horns excessive usn expsoure preglmligant to SCC |
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aminoglycosides affect |
30 x no initiation |
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tetracyclines |
30 s later no a site |
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linezolid |
50 s initiation |
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chalormphenicol |
pepitydltranferse 23s |
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macorlides |
50 s translocation |
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clindamycine |
50s translocaiton |
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lincosamine |
50s translocation |
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streptogrmain
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50s transloation |
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tranlsocation for eurkarotyoes |
ef2 |
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translocaiton for pro |
efg |
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golgi n oligo |
asparagine |
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golgi o oligo |
serinie and threonine |
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i cell |
defefct in n acytelglucosaminoal 1 phosphortransfer can't attach m6p because defect in mannose phsophorylation on glycoproteins extracellular secretion |
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i cell presentaiton |
coarse facies clouded corneas restricted joint high plasma of lysosomal enzymes |
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menkes disease |
x linked r disase cauesd by impaired copper absorption transport due to defetives menkes protein atp7a decrease lsusl oxidase brittle inkey hair growth retardation hypotonia |
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collagen has alot of |
hydroxylated lysine and prolines glycosylation hydroxylated lysines glycines |
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elastin has |
nonhydroxylated lysine and proline glycine |
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tropoelastin with scafollidng wfofibirllin |
crss linking takes places extraceullarly |
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marfans |
defect in fibrillin |
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emphysa |
excess alpha 2 antirpypse decrease slatin |
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mccune albright |
mutation affecting g protein signally unilateral cafe au lati spots polyostici fiborus dysplasia preciocious puberty endocrine abnormalies unilateral f/o nf1 |
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g6pd drugs |
sulfaonamides primaquine neitrfurotoin isonaisid fava beans dapsone chorlaquine |
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elevated epo levels |
pheochromocytooma renal cell cardinoma hepatocellular carcinoma hydrpnephrosis |
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sulfa allergy |
sulfasalazine probenecid furosemide celecoxib thaizide tmpsmx acetaolamide sulfonamides |
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metronidiazole treatment |
giardia entameba trichomoas gardnella anearobs h pylori |
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sjs syndrome |
penicillin drugs sulfadrugs seizure drugs allopurinol |
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inhibit dihydroflate reductase |
methotrexate tirmethoprim pyrimethamine |
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tetracycline uses |
vibro cholera acne chalymdia ureaplasma mycpolasma pneumonia tuelriemia borrelia burgdorie ricketsia |
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amoxicilin and ampcilin uses |
helicobacter pylori haemophilus influenza e coli listeria proteus slamonella shigella |
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school fish bacteria |
haempohilus ducreyi |
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protease inhibitors |
ritonavir abacavir squainavir inidavir nelfinavir fosamprenavir lopinavir tirpanavir atazanavir darunavir |
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pancreatitis with hiv drugs |
ritonavir |
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nephrolithtis siwht hiv drug |
iridinavir atazanavir |
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increase bilirubin with hiv drugs |
indiavir |
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all protease i drugs |
gi inteorlance hyperlipiedemia lipodistroyphy |
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nrti drugs |
zidovudine didanosine lamivudine abacavir emtrictiabine tenofovori |
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zidovuine causes |
bone marrow supresison |
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pancreatities/heatptatid steaotiss with nrti |
didanosine stavudine |
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allergic reaction with nrti |
abacvavir |
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nnrti |
nevirapine delaviridine efavirenz etravirine rilprivirine |
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nnrtis all cause |
rash |
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wierd drugs with hiv drugs |
efavirnnz |
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positive cannoid test |
efavirenz |
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teratogenic |
efavierenz |
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sCID |
failsure to thrive reccurent t and b cell and protozoal tx bone marrow translplate with no issue with rejection xr |
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ataxia telangiectasia |
atm gene: unable to repair dna double strand breaks |
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ataxia, telangiectasias, recurrent infections, iga deficient increase AFP cerebellar atrophy |
ataxia telangiectasia |
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elevated igm decreased igm, iga ige |
hyper Igm |
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Hyper Igm |
cd40l th cell defective, no class switch xr |
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WAS |
xr defect in was gene t cells unable to rearrange actin skeleton |
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thrombocytogenic purpura eczema reucrrent infections |
was increase ige iga platelets are small |
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dleayed separation of umblical cords |
lad |
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lad type I |
lfa 1 integrin defect cd 18 delayed healing of mblical cord increase neutrophilia no neutrophils in infections site |
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chediak higashi |
defect in lyst gene MT disfunction in phagolycose function ar |
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recurrent pyogenic infections albinisms lymphohistocytosis infections of staph and strep neuropathy |
chediak higashia |
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cgd |
defect in nadph oxidase clear nitroblue terazolium die anbdmorna dihydrorhodamine test xr |
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mpo defect |
blue nitroblue tetrazolium increased candida infections |
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catalse positive |
cryptospriudm staph aureus asperigillus psuedomas listeria serratia e coli |
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defeicent in nuetrophils |
staph burkhorderia cepcaica psuedonomas serratia nocarda and systpeic candia and asperigillus |
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local candida infections |
t cell infection |
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hyper acute signs |
wide spread thrombosis |
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acute fejection |
dense intersitla lymphocitic infiltrate |
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chornic |
months to years smooth muslce and parencyla fibrosis arterioslchoerisis |
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gvhd |
maculopapular rash jaudnice diarrhea heatopslenomegaly |
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aldesluekin to rcc |
increase nk cells |
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anti jo1 anti srp snti mi2 |
polymyosisitis
dermatomyositis |
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1 billary cirrhos |
anti mitochidrial |
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anti u1 rnp |
mixted connective tissue diseaser |
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rheumatic fever |
type II |
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post strep glmeroulonerphitis |
type III |
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contact dermitits poisin ivy |
cd 8 mediated type IV |
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hla a3 |
hermochortomisis |
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hla b27 |
psoritiatc arhitisi anklyosing spolyitidis ibd reactive arthitisi |
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hla dq2 hla dq8 |
celiac disease |
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hla dr2 |
ms hay fever sle good pasture |
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hla dr3 |
diabetes melit type 1 sle graves disease hasthiotic throdiitis |
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hla dr4 |
rheumoatoid arithitis dm type 1 |
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hla dr5 |
pernicious anemia hashimotos |
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cd 16 |
binds fc of bound ig to activate nk to kill antibody depend cytotic killing |
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cd 14 |
recongized tlrs |
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mch II |
ag loadedin endosome with relase of invariant chain |
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mch I |
loaded in rer with tap |
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caseating granulomas |
tb fungus |
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noncaseating granulomas |
berrilym sarcoiodisis foregin bodies crohns cat scratch : neturophils stellate shaped |
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cd25 |
il2 r autoimmunity may cause ms and dm type 1 |
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fox p3 deficit |
ipex autoim immune diarrhea endocrine ecxeuma |
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adcc |
ig g ig3 worms |
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ig meidated |
fc gapha r to nk cells |
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c3 for classical and mannose binding |
c4b2b |
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c5 convertnase for classicla and mannose binding |
c4b2b3b |
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alternative binding microbial surface c3 convertase |
c3bBb |
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c5 convertase altenrative |
c3bBb3b |
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classical pathway activation |
igMIgG |
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alemtuzumab |
cd52 cll |
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bevacizumab |
vegf colorecal and renal cell |
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cetuximab |
egfr stage 4 colerectal andheadn neck |
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rituximab |
cd20 b cell nod hodgikins |
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tratuzumab |
her 2 neu |
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adalimumab infliximab |
soluable tnf alpha |
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etanercept |
decoy tnf alpha recetpor |
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eculizumab |
c5 PNH |
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natalizumab |
alpha 4 integrin wbc ahdision risk of pml in jc virus |
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abciximab |
gp IIb/IIIa |
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denosumab |
rankl osteoprosis tx |
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omalizumab |
ige asthma binds to fcer1 |
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palvizumab |
rsv f protein prophylaxis for infants |
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ranibizumab vevacizumab |
vegf neovasuclar related |
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abxs to avoid in pregnancy |
aminoglycosides fluroquinoles tetracycines |
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drugs to avoid renal damage |
ace i arbs |
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drugs to avoid in pregnacy nt defects |
methotrexate carbamezpine vaproic acid isotretinoin |
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drugs to avoid in pregnacy facial abnormalities |
cyclophsopamide pheytoin fetal hydrantoin syndromewarfarin statins thalidomide |
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ebsteins anomaly in pregnancy |
lithium |
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n menigitidis causes |
high fever chills altered mentation petitecakl skin rash from bacterial induced small vessel vasculitites leadining to septic shock |
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yeast only |
cryptococcus |
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rhinovirus infects via |
icam 1 cd 54 |
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cytomegalovirus infeects |
cellular integrins |
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supression to highdose dexmethosone test |
pituatary adenoma |
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high grade fever pneumonia gi symptoms |
legionalla |
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strep pneumonia |
optochin sensitive bile soluble (cell lysis in bile) |
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perfusion defect |
alveolar and trachael air will have the same values with decrease in pco2 |
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pgi |
decrease plastlet aggregation decrease vasulcar tone decrease bronchila tone decrease uterine tone abolishes contractions |
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pge2 and pgf2a |
increase uterinte tone decrease vascular tone decrease brochinal tone increase gastric muscus production |
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txa2 |
increase platelet aggregationincrease vasulcar tone increase borhcila tone |
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target cells seen in |
hbc appslenia liver thallsemia |
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heparin monitor |
ptt |
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warfarin monitor |
pt |
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alpha thalsemia caused by |
gene deletions |
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beta thalasemia |
point mutations and splice sight issues |
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5ht mad ein |
raphe nucelus |
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ach made in |
basal cell of meynert |
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cooperative play by |
age 4 |
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nystagus with drugs |
pcp |
