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12 Cards in this Set
- Front
- Back
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Most important P450 are ?
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3A4 (50%) and 2D6
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1A2 substrate, inducer
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1A2 :
Sub - Acetominophen Ind - Smoking |
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2A6 substrate, inducer, inhibitor
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2A6:
Sub - Coumarin Ind - Rifampin Inh - Methoxsalen |
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2B6 sub, ind, inh
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2B6:
Sub - Retinoic Acid Ind- Phenobarbital Inh - Clopidogrel |
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2D6 sub, ind, inh
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2D6:
Sub - Metoprolol, propafenone Ind - Rifampin Inh - Quinidine |
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3A4 sub, ind, inh
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3A4:
Sub - Acetominophen, cannabinol Ind - Macrolides, glucocorticoids Inh - Grapefruit juice |
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Phenobarbitals and Rifampin induce metabolism of?
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Coumarin, digitoxin, steroids, estradiol
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Isoniazid inhibit metabolism of ?
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Tolbutamide, coumarin
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Ethanol inhibits metabolism of ?
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Diazepem
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Grapefruit juice inhibits metabolism of ?
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Atorvastatin, cyclosporine
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Itraconazole inhibits metabolism of ?
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Digoxin, quinidine
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Spironolcatones inhibit metabolism of ?
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Digoxin
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