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24 Cards in this Set
- Front
- Back
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Benserazide
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dopa decarboxylase inhibitor
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Entacapone
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COMT inhibitor
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Levodopa Indications
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PK
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Levodopa SE
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n/v
orthostatic hypotension, dyskinesia psych sx (depression, hallucinations, agitation, confusion) anorexia insomnia mydriasis (dilation of pupil) |
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Levodopa Counselling & Labels
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9, 16
! take this medication at the same time each day and in the same way (e.g. always before food) ! may cause discolouration of urine (red) and faeces (black) ! do not crush, chew or halve CR preps (A) |
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Levodopa Monitoring
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LFT (entacapone)
GI bleeding HR, BP |
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Dopamine Agonists
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Bromocriptine
Cabergoline Pergolide |
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DA agonist Indications
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PK
Acromegaly Hyperprolactinaemia |
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DA agonist SE
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n/v (act on DA receptors in CTZ)
GI upset orthostatic hypotension, dizzy psych sx (hallucinations, confusion, delusions, psychotic episodes) dyskinesia fatigue |
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DA agonists Counselling and Labels
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12, 16, B
- start at night |
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DA agonist Monitoring
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Carb & Brom:
prolactin levels visual field (pituitary enlargment) BP behaviour progressive fibrotic disorders Pergolide manufacturer recommends regular CV evaluation ECG @ 0, 3-6, then every 6-12months |
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Benztropine
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blocks muscarinic actions of Ach thus DEC. the relative excess of cholinergic activity that accompanies dopamine deficiency in PD
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Benztropine Indications
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Parkinson’s disease
Drug-induced EPS (except tardive dyskinesia) |
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Benztropine SE
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rash,
dry mouth/eyes, blurred vision, constipation, urinary retention, arrhythmia, dizziness, drowsiness, headache |
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Benztropine Counselling and Labels
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1, 9, 16
! this medicine may cause drowsiness, dizziness or blurred vision and may increase the effects of alcohol; if affected, do not drive or operate machinery |
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Benztropine Monitoring
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IOP
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Baclofen Indications
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Chronic spasticity associated with multiple sclerosis and spinal cord lesions
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Baclofen SE
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GI upset (nausea, vomiting, constipation, diarrhoea)
respiratory depression muscular weakness, myalgia drowsiness, dizziness, headache CNS effects (insomnia, confusion, euphoria, depression, hallucinations, ataxia) nystagmus, tinnitus, visual disturbances urinary disorders (enuresis, urinary retention) |
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Baclofen Counselling and Labels
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1, 2, 9, B
- Baclofen may cause drowsiness, dizziness or affect your vision; if you are affected, do not drive or use machinery. - Avoid drinking alcohol as it may worsen some of the side effects of baclofen. - Do not stop taking this medicine suddenly unless your doctor tells you to. Severe withdrawal syndrome may occur if baclofen is stopped suddenly. |
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Baclofen Monitoring
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RF, BGL, LFT
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Amantadine Indications
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PK
Prevention of influenza type A in non-immunised people |
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Amantadine SE
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dry mouth, blurred vision, constipation, urinary
retention, orthostatic hypotension, dizziness, depression, nightmares, hallucinations |
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Amantadine Counselling and Labels
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9, 12, 16 B
! with or soon after food to reduce stomach upset |
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Amantadine Monitoring
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Vision
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