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45 Cards in this Set
- Front
- Back
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Nitrogen mustards
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N7 adducts
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Cyclophosphamide
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Prodrug
Activated to phosphoramide mustard & acrolein |
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Nitrosoureas
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Crosses BBB
Alkylater & carhamoylator |
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Cisplatin
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1,2-intrastrand adducts on N7 of purines
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Methotrexate
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Competitive inhibitor of DHFR (thymidylate syntehsis)
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Leucovorin
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Methotrexate antidote
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5-FU
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Converted to fUMP then f-dUMP; irreversible inhibitor of thymidylate synthetase
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Purine analogues
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Dummy incorporation
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Danuorubicin/doxirubicin
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Intercalate, inhibit topoII, create ROSs
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Etoposide, tenoposide
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TopoII inhibitor (late S-G2 stop)
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Vincristine, vinblastine
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Microtubulin depolymerization
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Paclitaxel
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Microtubule stabilizer
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Tamoxifen
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Competitive ER antagonist for ER+ BC
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Traztuzumab
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Monoclonal Ab for HER2 receptor, blocking growth factor receptor site & causing ADCC
Cancer-specific |
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Bevacizumab
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Monoclonal Ab for VEGF, binding to the region of VEGF that binds receptor
Stops angiogenesis, used with 5-FU |
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Prednisolone
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Inhibits PLA2; inhibits T cell proliferation, cytokine expression, cell-mediated immunity
Organ transplant, asthma, autoimmune disease except diabetes |
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Cyclosporin
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Binds cyclophillin, inhibiting calcineurin & txn of IL2, IL3, IFNgamma
Kidney transplant, autoimmune disorders Nephrotoxic, hyperglycemia, hyperlipidemia, osteoporosis |
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Sirolimus
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Binds immunophyllin blocking T cell response; inhibits B cell proliferation & Ig production
Kidney, heart allografts; skin & eye AEs |
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Tacrolimus
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Binds FK-binding protein inhibiting T cell activation
More potent, less nephrotoxic Liver & kidney transplants |
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Infliximab
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IgG1 Ab, suppress cytokine generation
Crohn's, RA |
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Etanercept
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mAb, similar but shorter t1/2
RA |
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Mycophenolate mofetil
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Inhibits de novo purine snyhtesis, T & B lymphocyte responses
Renal & heart transplants, autoimmune disorders |
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Thalidomide
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Suppresses TNF-alpha, favours TH2 over TH1
Antiangiogenic Lupus, lung transplants, cancer |
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Azathioprine
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Metabolized to 6-mercaptopurine; inhibit purine synthesis, cell & humoral responses
Renal allograft, autoimmune diseases Teratogen, bone marrow suppression |
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Leflunomide
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Prodrug of pyrimidine synthesis inhibitor; inhibits lymphoid cells
RA Hepatic dysfunction, renal impairment, teratogenic |
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Cyclophosphamide
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Destroys proliferating lymphoid cells, most potent
Pancytopenia, hemorrhagic cystitis Autoimmune disorders, acquired factor XIII Abs, bleeding syndromes |
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Antisera
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From animals; isolate IgG
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Anti-thymocyte globulin
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Thymus from dead animal, immunize with lymphoid cells, act on small long-lived circulating T cells
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Rh immune globulin
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Rh- mother
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IVIg
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Reduce systemic inflammation; primary immunodeficiency
From donors |
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Hyperimmune immunoglobulin
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IVIg high titre Abs with specific immunity
Eg ITP patients who are RhD+ with spleen |
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Muromonab
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CD3 mAb, T-cell-specific
Renal, heart transplants |
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Palivizumab
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RSV
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Rituximab
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Follicular B-cell non-Hodgkins lymphoma
Anti-CD20 (B cells) |
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Traztuzumab
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Metastatic breast cancer (HER2)
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IFN-alpha
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Leukemias, malignant melanoma
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IFN-beta
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Relapsing-type MS
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IFN-gamma
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Chronic granulomatous disease
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IL-2
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Metastatic renal carcinoma, malignant melanoma
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TNF-alpha
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Malignant melanoma, soft-tissue sarcoma
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GM-CSF
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Melanoma, prostate cancer
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Levamisole
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Clinically-used adjuvant
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Bacille Calmette-Guerin
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Adjuvant
Viable bacterial strain; TB |
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Pyran copolymer
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Adjuvant
Activate macrophage; MS |
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Other adjuvants
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Freunds, synthetic polynucleotides (I:C for IFN, A:U for Th), thymosin, bacteria & products
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