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118 Cards in this Set
- Front
- Back
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Indomethacin
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COX-I
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Alprostadil
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PGE1
Keep ductus open; impotence |
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Misoprostol
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PGE1
Prevent GI ulcers |
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Dinoprostone
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PGE2
Labour & abortion |
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Carboprost, dinoprost
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PGF2
Labour & abortion |
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Epoprostinol
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PGI1
Prevent clotting; vasodilation |
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Auranofin
Sodium aurothiomalate |
Inhibit immune cell activity
Disease-modifying in rheumatoid arthritis |
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Methotrexate
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Rheumatoid arthritis
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Sulfasalazine
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Rheumatoid arthritis
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Hydroxychloroquine
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Rheumatoid arthritis
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TNFalpha, IL-1 monoclonal Abs
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Rheumatoid arthritis
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Aspirin
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COX1&2 inhibitor
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Diclofenac
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COX1&2 inhibitor
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Fenoprofen
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COX1&2 inhibitor
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Flurbiprofen
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COX1&2 inhibitor
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Indomethacin
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COX1&2 inhibitor
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Naproxen
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COX1&2 inhibitor
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Piroxicam
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COX1&2 inhibitor
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Celecoxib
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COX2 inhibitor
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Etodolac
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COX2 inhibitor
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Meloxicam
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COX2 inhibitor
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Rofecoxib
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COX2 inhibitor (highly selective)
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5-ASA
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COX1&2 inhibitor
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Diflunisal
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COX1&2 inhibitor
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Sodium salicylate
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COX1&2 inhibitor
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Nabumetone
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COX1&2 inhibitor
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Sulphalazine
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COX1&2 inhibitor
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Acetaminophen
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FAAH conjufation, central TRPV1 agonist
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Diphenhydramine
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H1 antagonist
1st gen Allergies, colds |
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Loratadine
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H1 antagonist
2nd gen Allergies, colds |
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Terfenadine
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H1 antagonist
2nd gen Allergies, colds |
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Cimetidine
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H2 antagonist
PUD, GERD |
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Ranitidine
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H2 antagonist
PUD, GERD |
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Epinephrine
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Beta agonist
Acute asthma Increase local anesthetic duration of action |
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Ephedrine
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Beta agonist
Acute asthma Increase local anesthetic duration of action |
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Isoproterenol
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Acute asthma
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Albuterol
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Acute asthma
Beta2 agonist |
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Terbutaline, fenoterol
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Beta2 agonist
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Salmeterol
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Beta2 agonist
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Formeterol
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Beta2 agonist
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Theophylline
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Methylxanthine
Asthma |
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Theobromine
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Methylxanthine
Asthma |
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Roflumilast
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Methylxanthine
Asthma and COPD (especially) |
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Atropine, ipratropium bromide
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Muscarinic antagonist
Resistant asthma; COPD |
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Beclomethasone
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Asthma (chronic)
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Flunisolide
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Asthma (chronic)
Corticosteroid |
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Triamcinolone
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Asthma (chronic)
Corticosteroid |
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Ciclesonide
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Asthma (chronic)
Corticosteroid |
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Zileuton
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Asthma (chronic)
Inhibit 5-lipoxygenase (leukotrienes) |
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Zafirlukast, montelukast
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Asthma (chronic)
Inhibit LTD4 R binding |
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Cromolyn, nedrocromil
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Asthma (chronic)
Alter Cl- channel to inhibit mast cell activation |
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Omalizumab
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Asthma (chronic)
IgE monoclonal Ab |
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Alpha-1 antitrypsin
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COPD (congenital AAT deficiency)
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Digoxin
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Heart failure
Inhibit Na+/K+ ATPase |
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Dobutamine
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Heart failure (acute), especially with hypotension
Beta agonist |
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Inamrinone
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Heart failure
Phosphodiesterase inhibition |
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Levosimedan
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Heart failure
Ca2+ sensitizer |
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Ivabradine
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HF, arrhythmias (slow HR)
If channel inhibitor |
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Quinidine, procainamide, disopyramide
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Arrhythmia
Int. Na+ channel blockers |
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Lidocaine, mexiletene
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Arrhythmia
Fast Na+ channel blocker |
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Propafenone, flecainide
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Arrhythmia
Slow Na+ channel blocker |
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Amiodarone
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Arrhythmia
K+ channel blocker |
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Sotalol, sematolide
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Arrhythmias (slow HR)
K+ channel blocker |
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Dronedarone
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Arrhythmia
K+ channel blocker (slow HR) |
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Azimilide
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Arrhythmia
K+ channel blocker |
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Glyceryl trinitrate
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HF, angina
Activates sGC, increasing cGMP and Ca2+ sequestration Venodilator |
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Isosorbide dinitrate
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HF, angina
Activates sGC, increasing cGMP and Ca2+ sequestration Venodilator |
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Sodium nitroprusside
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HT emergency, mitral/aortic regurgitation
NO donor Balanced dilator |
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Nesiritide
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HF
BNP analog to increase cGMP Venodilator |
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Hydralazine
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Hypertension, HF, kidney disease
Decrease cGMP, IP3, Ca2+ Arterial |
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Furosemide
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Loop diuretic
Inhibit Na+/K+/2Cl- cotransporter in distal ascending tubule |
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Bumetanide
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Loop diuretic
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Torasemide
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Loop diuretic
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Chlorothiazide
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HT, mild-moderate CHF, kidney disease
Thiazide diuretic |
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Chlorthalidone
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Thiazide diuretic
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Acetazolamide
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Glaucoma, respiratory alkalosis, HT/CHF
Inhibit bicarbonate reabsorption |
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Spironolactone
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Hepatic cirrhosis, CHF
K+ sparing diuretic Aldosterone R antagonist |
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Trimeterene, amiloride
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K+ sparing diuretic
Na+ pore antagonist |
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Mannitol, urea
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Brain edema, CV surgery, renal failure
Osmotic diuretic |
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Propranolol, metoprolol, atenolol, pindolol
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HT
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Prazosin, phentolamine, labetalol
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HT
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Methyldopa, clonidine, reserpine
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Resistant HT
Indirect sympethetic antagonists |
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Nifedipine
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HT
DHP Ca2+ channel blocker |
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Verapamil
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HT
Non-DHP Ca2+ channel blocker |
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Captopril, enalapril
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HT
ACE-Is |
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Losartan
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HT
Angiotensin receptor blocker |
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Aliskiren
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HT
Renin inhibitor (potential) |
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Minoxidil
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HT
Vasodilator -- increase opening time of K+ channel |
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Atorvastatin, fluvastatin, lovastatin, pravastatin, simvastatin, rosuvastatin
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Hyperlipoproteinemias
Inhibit HMg-CoA reductase |
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Cholestyramine, colestipol
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Hyperlipoproteinemias
Cationic resin - prevent intestinal bile acid absorption |
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Neomycin
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Hyperlipoproteinemias
Prevent intestinal bile acid absorption |
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Ezetimibe
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Hyperlipoproteinemias
Prevent intestinal absorption of dietary, biliary cholesterol (NPC1L) |
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Nicotinic acid (niacin)
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Hyperlipoproteinemias
Inhibit FFA release from adipose |
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Clofibrate, fenofibrate, gemfibrozil
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Hyperlipoproteinemias
Stimulate PPAR-alpha activity |
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Cholestyramine, colestipol
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Hyperlipoproteinemias
Cationic resin - prevent intestinal bile acid absorption |
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Neomycin
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Hyperlipoproteinemias
Prevent intestinal bile acid absorption |
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Ezetimibe
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Hyperlipoproteinemias
Prevent intestinal absorption of dietary, biliary cholesterol (NPC1L) |
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Dipyridamole
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Inhibit platelet phosphodiesterase
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Ticlopidine
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Inhibit ADP binding to platelet receptor --> reduce glycoprotein IIa/IIIb receptor
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Clopidogrel
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Inhibit ADP binding to platelet receptor --> reduce glycoprotein IIa/IIIb receptor
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Abciximab, eptifibatide, lamifiban, tirofiban
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GPIIb/IIIa receptor monoclonal Abs
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Heparin
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Increase anti-thrombin III activity
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Enoxaparin, dalteparin
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Low MW heparin
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Protamine
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Heparin antidote
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Hirudin, lepirudin, bivalirudine
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Inhibit thrombin
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Warfarin
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Vitamin K antagonist
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Streptokinase, tPA, tenecteplase
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Plasminogen activator
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Dipyridamole
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Inhibit platelet phosphodiesterase
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Ticlopidine
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Inhibit ADP binding to platelet receptor --> reduce glycoprotein IIa/IIIb receptor
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Clopidogrel
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Inhibit ADP binding to platelet receptor --> reduce glycoprotein IIa/IIIb receptor
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Abciximab, eptifibatide, lamifiban, tirofiban
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GPIIb/IIIa receptor monoclonal Abs
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Heparin
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Increase anti-thrombin III activity
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Enoxaparin, dalteparin
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Low MW heparin
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Protamine
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Heparin antidote
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Hirudin, lepirudin, bivalirudine
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Inhibit thrombin
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Warfarin
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Vitamin K antagonist
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Streptokinase, tPA, tenecteplase
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Plasminogen activator
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Methylene blue
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Electron donor to correct methemoglobinemia
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