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15 Cards in this Set
- Front
- Back
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Diuretics |
MOA: decr. fluid and PVR Effect: |
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ACEi |
MOA: inhibit conversion of ATI to ATII via ACE Major Effect: decrease PVR and BP Decrease: vasoconstriction, aldosterone, fibrosis, ADH, degradation of bradykinin (VD), efferent arterial resistance, microalbuminuria |
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ARBs |
MOA: Competitive antagonist of ATII at the AT1 receptor Major Effect: decrease TPR and BP Decrease: vasoconstriction, aldosterone, ADH, catecholamine release Increase: AT2 activity = vasodilation |
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Direct Renin Inhibitors |
Aliskiren See ACEi; similar decr. in BP |
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Beta Blocker |
MOA: Effect: lower BP Decrease: CO, renin, sympathetic outflow |
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Beta Receptor Stimulation |
BV: dilation Heart: incr. tachycardia and induce contractility |
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Alpha Receptor Stimulation |
BV: constriction Heart: incr. contractility |
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Alpha Blockers |
MOA: at a post-synaptic alpha 1 receptor to prevent catecholamine induced vasoconstriction Effect: arterial and venous dilation, decr. TPR and decr. arterial pressure |
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CCB |
MOA: block channel from allowing Ca to enter cardiac and SM Effect:Arterial vasodilators, decr. rate and force of contraction, decr. BP |
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Minoxidil |
MOA: opens ATP modulated K channel causing hyperpolarization, a decr. in Ca entry and relaxation of SM Effect: decr. TPR and BP |
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Hydralazine |
Decr. TPR and BP |
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Sodium Nitroprusside |
MOA: breaks down in NO Major: decr. TPR and BP Effect: venous pooling, decr. arterial resistance |
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Other Nitrates |
MOA: enzymatically converted to NO Effect: vasodilation, decr. preload and afterload (decr. heart O2 requirements) |
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Clonidine |
MOA: stimulate a2 receptors in the brain, decr. sympathetic outflow and BP Decreases: TPR, HR, CO, BP |
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Methyldopa |
MOA: depletes source of norepi (VC) but mainly stimulate a2 receptors in the brain, decr. sympathetic outflow Decreases: TPR, CO, BP |
