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A-44. MOA, indications, contraindications of Voriconazole?
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MOA: interact with fungal P450 which blocks demethylation of lanosterol to ergosterol - fungal cell death
Ind: DOC for aggressive Scedosporium apiospermum and Fusarium species CI: OCPs SE: photosensitivity, hepatotoxicity, skin reactions, transient visual changes |