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17 Cards in this Set
- Front
- Back
Acute Liver Failure Criteria (3) ?
|
1. Increasing coagulopathy
2. Hepatic encephalopathy 3. Jaundice |
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Causes of Acute Liver Failure ?
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1. Drug-induced
2. Viral hepatitis 3. Autoimmune 4. Shock / hypoperfusion 5. Idiopathic /unknown |
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Miscellaneous causes of Acute Liver Failure?
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1. Wilson's disease
2. Budd Chiari Syndrome 3. Autoimmune 4. Cardiogenic 5. Pregnancy-related |
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Viral causes of acute liver failure?
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1. HBV
2. HCV 3. HSV-Herpes Simplex Virus 4. EBV 5. CMV 6. VSV-Varicella Zoster Virus |
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Drug causes of acute liver failure?
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1. Paracetamol
2. NSAIDS 3. Steroids 4. Anticonvulsants 5. Anti-tuberculous therapy 6. Herbal remedies 7. Recreational drugs {ecstasy ; cocaine} 8. IDIOSYNCRATIC |
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Drugs causing Idiosyncratic drug reactions
causing acute liver failure? {11 categories} |
1. Antibiotics [ Augmentin ; ciprofloxacin ; doxycycline ; erythromycin ; isoniazid ; nitrofurantoin ; tetracycline ; sulphonamides ]
2. Antivirals [ fialuridine] 3. Antidepressants [ amitriptyline ; nortriptyline ] 4. Oral hypoglycaemics [metformin ; troglitazone ] 5. Anticonvulsants [ phenytoin ; valproate ] 6. Anaesthetics [ halothane ] 7. Statins [ atorvastatin ; simvastatin ] 8. NSAIDS 9 Salicylates [ Reye's Syndrome] 10. Anti-thyroid drugs [ PTU] 11. Antiarrhythmics [ amiodarone ] 12 Immunosuppressants [ MTX ; Gold ; cyclophosphamide ] |
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Infectious mimics of Acute Liver failure at
presentation? [Returned Traveller] |
1. Falciparum malaria
2. Typhoid fever 3. Leptospirosis 4. Dengue fever |
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The 4 Grades of hepatic encephalopathy ?
|
Grade I : Drowsy -coherent
Grade II : Drowsy -confused - inappropriate Grade III : Very drowsy + stuporose + restless + agitated Grade IV : Comatose |
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Patients with Acute Liver failure secondary to what conditions should be listed for OLT
{transplantation}? |
1. Mushroom poisoning
2. Wilson's Disease 3. Autoimmune hepatitis 4. Hepatic vein thrombosis |
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Which Causes of Acute liver failure have the
better outcomes? |
1. Paracetamol
2. Pregnancy 3. Hepatitis A |
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Which causes of Acute liver failure have the poorer outcomes?
|
1. Seronegative hepatitis
2. Non-A non-B viral hepatitis 3. Idiosyncratic drug reactions 4. Wilson's disease
|
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Prognostic scoring systems for Acute liver failure and transplantation requirement?
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1. King's College (London) Criteria
2. Clichy 3. MELD ( Model for Endstage Liver disease) |
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Tintinalli
The most common cause of Acute Liver Failure (in U.S) is ? |
Acetaminophen (paracetamol)
|
|
(Tintinalli)
What are the Pathophysiological consequences of Hepatocellular death? |
Disruption of liver METABOLIC AND
SYNTHETIC function |
|
(Tintinalli)
Which of the following is incorrect? A. Patients with alcoholic liver disease can present with acute hepatitis B. HBV is the most common of all blood borne infections in the US. C. AN AST : ALT ratio of > 2 usually suggests alcoholic hepatitis D. A prolonged PT and elevated bilirubin (>20) indicates significant disruption of liver function. |
B. HCV- Hepatitis C Virus
|
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(Tintinalli)
What is the "continuum" of progression of alcoholic liver disease? |
|
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(Tintinalli)
What are the 4 pathological mechanisms of medication-induced liver disease? |
1. Hepatocellular necrosis (Paracetamol)
2. Cholestasis ( OCP ; steroids) 3. Steatohepatitis (amiodarone) 4. Chronic disease ( Nitrofurantoin) |