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10 Cards in this Set
- Front
- Back
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A-42. MOA and indications of Amphotericin B?
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MOA: binds to ergosterol and creates a pore in fungal cell membrane inducing electrolyte imbalance and death
Ind: DOC for Aspergillus mucormycoses (mold), cryptococcal meningitis (along w/ flucytosine) |
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A-42. What are the adverse side effects of Amphotericine?
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Kidney damage, hypokalemia, anemia, hypotension, and neurological defects - can all be reduced with lipid-based or liposomal amphotericine
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A-42. In aplastic anemia, hematopoiesis is inhibited, what will this cause cell-wise?
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Decreased erythrocyte, neutrophil, and platelet counts
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A-42. What is the pathognomonic blood smear in megablastic anemia?
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Hypersegmented Neutrophils
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A-42. What is elevated in B12 and Folate deficiencies?
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B12: methylmalonic acid and homocysteine
Folate: homocysteine only |
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A-42. What is the characterisitc lab finding of anemia of chronic disease?
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Decreased TIBC
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A-42. What is a sign of intravascular/extravascular hemolytic anemia on a blood smear?
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Intravascular: cell fragments
Extravascular: spherocytes |
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A-42. In homozygous b-thalassemia, what would electrophoresis show?
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Severely decreased HgB A and increased HgB F
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A-42. Children, teens, and young adults with sickle cell are at risk for _______ because of intravascular hemolysis episodes?
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Gallstones
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A-42. Microcytes, hypochromic and basophilic stippling of RBCs are all characterisitcs of what?
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Lead posioning
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