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21 Cards in this Set

  • Front
  • Back
what percentage of the circulating blood volume is stored in the veins?
60%
what are the 3 major groups of predisposing factors of thrombosis (Virchow's triad)?
1) stasis and other disturbances in blood flow
2) abnormalities in the vessel wall
3) changes in blood composition tending to increase its coaguability
which substances when released by platelets will stimulate further platelet aggregation?
ADP and thromboxane A2
what feature of aggregated platelets promotes coagulation?
activated phosolipid complex
What is factor V leiden?
factor V has mutated to be resistant to protein C
which deficiency has the highest relative risk of venous thromboembolism?
antithrombin III deficiency (RR 50)
what is the relative risk of venous thromboembolism associated with the OCP?
3.8
what is the RR of VTE associated with factor V leiden?
5-8
what does the lupus anticoagulant antibody bind to?
beta2 glycoprotein 1
which malaria is associated with cerebral malaria?
falciparum
how many layers of RBCs are in a thick film?
20-30
what are the characteristic thin film findings for P, falciparum?
samll ring forms (may be more than 1 per RBC), more than 1 chromatid dot, 5-10% RBCs parasitised
what is warfarin?
competitive Vit K antagonist
how is warfarin therapy monitored?
INR
what is the desirable INR for warfarin therapy for VTE?
2-3
how is warfarin reversed?
oral or IV vit K, prothrombin complexes, FFP
t/f... heparin has good oral bioavailability
false, heparin is only active parenterally
what are the advantages of LMWH over conventional heparin?
more predictable anticoag response, longer half-life, fewer side effects
what reverses heparin?
protamine
how is heparin monitored?
activated partial thromboplastin time (1.5 to 2.5 times the normal range)
name two drugs which directly inhibit thrombin
lepirudin, argatroban