40- Cell Adhesion And Movement

Front 1

Cell adhesion molecules

Back 1

CAMs- members of immunoglobulin superfamily (IgSF), the founding member called neural cell adhesion molecule (N-CAM) which are well organized loops. These act homophilically with CAMS on adjacent cells

Front 2

Cadherins

Back 2

group of adhesive glycoproteins found in plasma membrane: homophilic. These require Ca function. Ca binds to and stabilizes the conformation of cadherins and allows them to mediate cell cell adhesion

Front 3

E-cadherin

Back 3

epithelial cadherin has five domain repeats that are extracellular (protrude out) and zip together in homophilic fashion with another cell. Important in embryo

Front 4

selectins vs CAMs

Back 4

selectins snatches leukocyte
CAMs bind

Front 5

cell-cell junctions

Back 5

adhesive junctions
tight junctions
gap junctions

Front 6

Adhesive anchoring

Back 6

link cells together into tissues, enabling them to function as a unit. All anchor the cytoskeleton to the cell surface
-adheren junctions
-desmosomes

Front 7

Adherin junctions

Back 7

part of adhesive junctions: cadherin mediated adhesive junctions

points of attachment between cell surface and cytoskeleton

Front 8

desmosomes

Back 8

button like points of strong adhesion, important for structure

Front 9

tight junctions

Back 9

act like "fences" leave no space at all between plasma membranes of adjacent cells. block lateral movement of membrane proteins, act as "gates"

Front 10

hemidesmosomes

Back 10

anchor epithelial cells to basal lamina

Front 11

gap junction

Back 11

region where plasma membranes of 2 cells are aligned and brought into intimate contact with a small gap spanned by pipelines

Front 12

Extracellular Matrix

Back 12

some sort of anchor?

for epithelial cells- they produce basal lamina as ECM

Front 13

collagens are responsible for strenght of ECM

Back 13

proteins called collagens- form fibers and account for strength

Front 14

collagen and elastin fibers are embedded in a matrix of proeoglycans

Back 14

proteoglycans: glycosaminoglycans (GAG) in ECM are covalently bound to protein molecules to form this. provide structural integrity to ECM

Front 15

fibronectin

Back 15

family f closely related adhesive glycoproteins in the ECM and are widely distributed in vertebrates.

cell recognizes these and wants to grow on it

Front 16

basal lamina

Back 16

serves as structure support that maintains tissue organization. prevents passage of underlying connective tissue cells into the epithelium but permits migration of white blood cells needed to fight infections.

some cancer cells have increased binding to these

Front 17

Laminin

Back 17

3-long polypeptides. disulfide bonds hold these together. serves as bridging molecule that attaches cells to basal lamina.

Front 18

Integrins

Back 18

integrate cytoskeleton with extracellular matrix. important because they are primary means by which cells bind to ECM proteins such as collagen, fibronectin and laminin.

Front 19

focal adhesions

Back 19

migratory non epithelial cells such as fibroblasts attach to ECM via these. contain clustered integrins that interact with buncles of actin MF

Front 20

hemidesmosomes

Back 20

how epithelial cells attach to laminin in basal lamina