-4- Prions

Front 1

Stanley Prusiner

Back 1

Received the noble prize in Medicine for his work on prions (proteinaceous infectious particles)

Front 2

Infectious particles

Back 2

__________ _________ are inherited and transmissable by ingestion, transplants, & surgical instruments.

Front 3

Spongiform encephalopathies

Back 3

Sheep scrapie, Creutzfeldt-Jakob disease, Gerstmann-Straussler-scheinker syndrome, fatal familial insomnia, mad cow disease, several others.

Front 4

Prions

Back 4

Resistant to heating
Not sensitive to radiation treatment
Not destroyed by enzymes that digest DNA or RNA.
Not sensitive to protein denaturing agents, such as phenol.
Shown to move easily from species to another.

Front 5

PrPc

Back 5

Normal cellular prion protein, on cell surface.

Front 6

PrP sc

Back 6

The harmful form

Scrapie protein is believed to result from mutation in a normal gene for PrPc, or contact with the altered/harmful form converts the normal protein into harmful form.

Front 7

plaques

Back 7

The harmful PrPsc form accumulates in brain cells forming __________.