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7 Cards in this Set

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Stanley Prusiner
Received the noble prize in Medicine for his work on prions (proteinaceous infectious particles)
Infectious particles
__________ _________ are inherited and transmissable by ingestion, transplants, & surgical instruments.
Spongiform encephalopathies
Sheep scrapie, Creutzfeldt-Jakob disease, Gerstmann-Straussler-scheinker syndrome, fatal familial insomnia, mad cow disease, several others.
Prions
Resistant to heating
Not sensitive to radiation treatment
Not destroyed by enzymes that digest DNA or RNA.
Not sensitive to protein denaturing agents, such as phenol.
Shown to move easily from species to another.
PrPc
Normal cellular prion protein, on cell surface.
PrP sc
The harmful form

Scrapie protein is believed to result from mutation in a normal gene for PrPc, or contact with the altered/harmful form converts the normal protein into harmful form.
plaques
The harmful PrPsc form accumulates in brain cells forming __________.