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25 Cards in this Set
- Front
- Back
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GH pharm agents
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SERMORELIN was released to beef up our SOMATROP (in)
Wasn't enough had to have an IGF MECASERMIN |
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GH analog
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SOMATROP (in)
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SOMATROPin
moa indication |
GH analog-->JAK STAT
gh def, cachexia(non neo) p-willi, kids CRF, idiopathic short (must have documetation |
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GH challenge
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levadopa, arginine,clonidine, glucagon, insulin induced hypoglycemia
all should = gh release |
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GHRH agonist
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SERMORELIN
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IGF-1 agonist
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MECASERMIN
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Rx acromegaly, Gigantism
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gh EXCESS (USUALLY PIT TUMOR)
PEGVISOMANt BROMOCRIPTINE OCTREOTIDE Went too far, PEGVISOMAN stopped the sermin BROMOCRIPTINE stole the dope (it was a tumor) and the soma OCTREOTIDE |
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BROMOCRIPTINE
Moa |
DOPAmine agonist (D1,D2)
paradox dec GH in tumors (incr normally) |
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PEGVISOMAN
moa SEs |
GH-R antagonist in liver
= dec IGF-1 secretion 2nd line drug (dec blood sugar and hepatotoxic) |
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Octreotide
Moa indic |
somatostatin analogue
(Gi--->dec Camp) dec GH (even shrinks some tumors) also carcinoid tumor, VIPoma hormonal diarrhea |
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ADH analog
named |
desmopressin--sc, or inranasal.....
has less V-constriction than ADH |
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desmopressin
indications |
• Diabetes insipidus (absence of ADH)
Control polydipsia, polyuria, dehydration) • Central diabetes insipidus (very rare) • Nocturnal enuresis (bed wetting)(NOT ANYMORE DUE TO HYPONATREMIA) • Hemophilia A (mild) • Von Willebrand’s dz (mild) |
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desmopressin
SEs |
• Water intoxication
• Hyponatremia Retain H2O…effectively decreased Na+ concentration • Caution in dz’s assoc w/ electrolyte imbalance (e.g. cystic fibrosis) • Nasal congestion, etc. may interfere w/ absorption of intranasal drug • Effects on bleeding disorders are limited (not that powerful) |
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Rx for hyperprolactinemia
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dopamine agonists-(-) PrL secretion
Bromocriptine (D1,D2) Cabergoline(D2) |
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somatotropin
SEs |
metabolic-hyper/hypoglycemia
fluid retention edema (attn HF) |
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somatotropin
CIs |
corticosteroids inhibit GH
Epiphyseal closure Active neoplastic disease Intracranial HTN Acute critical illness Caution in DM Caution in scoliosis (growth spurts dangerous) Hypothyroid pts will have inadequate response |
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causes of hyperprolactinemia
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Antipsychotics
lactation prolactinoma (the one to treat) CRF nipple stimulation polycystic ovarian disease |
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DRugs for hypothyroidism
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LEVOthyroxine(synthroid)
LIOthyronine LIOtrix Four pre thyr (levo)= T4 Three (lio) = T3 Three "trix" = both |
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Rx for Hyperthyroidism
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Propylthiouracil
methimazole K+ perchlorate I131 (kills thyroid Was freakin out they PROPYL-THIO-(UR ACIL) and ME THINAZOLE in Peroxide I tried to inhibit the pump the Pot (assium) perch (l) or Ate Oh tried to save me with the K+ IODIDE but they pulled out the big ALPHA to search me out |
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Propylthiouracil
methimazole MoA |
Inhibit Thyroid Hormone Synthesis
• BOTH Inhibit thyroid peroxidase enzyme • Propylthiouracil also inhibits conversion of peripheral T4 → T3 conversion Inhibits 5’-deiodinase |
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Propylthiouracil
methimazole SEs |
• Cross placenta & excreted in breast milk
↓ Thyroid hormone in fetus / neonate (-)’s CNS development (PTU more protein bound so better) • Granulocytopenia • Agranulocytosis • Hepatotoxicity (rare) |
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Potassium perchlorate
MoA SEs |
inhibit I pump
fatal aplastic anemia |
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potassium iodide
MoA uses SEs |
unkown mech
take quickly to reverse radioactive idodine SEs-• Pregnancy Can cause goiter / cretinism in fetus • Excreted in breast milk • Monitor K+ in patients with renal problems (e.g. acute dehydration, mm. cramps, adrenal insufficiency, CV disease) |
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THYROGEN ALPHA
moA uses |
TSH(ish) ?
used to test if all thyroid tissue is gone after ablation |
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I123
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for thyroid scan
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