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10 Cards in this Set
- Front
- Back
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A-4. Which achieves a higher "active" concentration in the body? Drugs that are easy or hard to knock off Albumin?
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Easy. When attached to albumin they are basically ineffective.
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A-4. What drugs are known for INDUCING P450?
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One Pharmaceutical Brings About Rapid Liver Metabolism:
OCPs, Phenytoin, Barbituates, Alcohol, Rifampin, Levodopa, Methadone |
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A-4. What drugs are known for INHIBITTING P450?
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Some Pharmaceutical Classes Inhibit Drug Catabolism:
Sulfonamides, Phenybutazone, Chloramphenicol, Isonazid, Dicumarol, Cimetidine |
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A-4. What are the drugs that are easily displaced from Albumin?
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Serum Proteins Can Spew (i.e. cough up easily)
Sulfonamides, Phenylbutazone, Coumadin, Sulfonylureas |
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A-4. What are the drugs that compete for renal transporters?
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Some Pharmaceuticals Plus Urate Stop Transporters
Sulfonamides, Probenecid, Penicillin, Urate (uric acid), Salicylate, Thiazides |
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A-4. Antiarrhythmics plus Fluoroquinolones may cause prolonged QT and Torsades except when combine with one specific Fluoroquinolone. Which one?
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Ciprofloxacin
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A-4. What drugs are known for causing hepatotoxicity?
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All imidazoles, Interferon, Nevirapine, all HMG CoA Inhibitors, Valproic Acid, Isoniazid, Carbamazepine
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A-4. What are the drugs that induce lupus?
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Hydralazine, Procainamide
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A-4. What drugs are known for causing nephrotoxicity?
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Amnioglycosides, Foscarnet, Cidofovir, NSAIDs, Cyclosporine, Amphotericin, Phenacetin
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A-4. Which drugs can cause neural tube defects if taken while pregnant?
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Carbamazepine, Valproic Acid
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