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13 Cards in this Set
- Front
- Back
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A-39. Prothrombin Time (PT) tests which pathways?
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Extrinsic and Common
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A-39. What is the tx for VWB Disease?
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VWF or humanate (purified factor VIII) +/- desmopressin, which releases factor VIII collected in and stored in endothelial cells
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A-39. What causes a vitamin K deficiency and which factors does it effect?
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Factors: 2,7,9, and 10 "1972"
1.) Fat malabsorption 2.) Antibiotics 3.) New borns (lack gut flora) 4.) Coumadin (warfarin |
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A-39. What are the cell types, pathophys, and tx for Thrombotic Thrombocytopenic Purpura?
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Cells: schistocytes
Path: spontaneous platelt aggregation w/ resulting in systemic platelet clot formation and consumption of platelets Tx: plasmapheresis |
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A-39. What causes hemolysis in G6PD defciency?
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Exposure to excess radicals because the RBCs cannot produce NADPH
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A-39. a-Thalassemia is due to decreased synthesis of __________ and characterized by __________ and ___________
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Alpha globin chain
Microcytic anemia and spenomegaly |
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A-39. C & C the causes of Warm and Cold autoimmune hemolytic anemia.
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Warm: drugs, malignancies, SLE
Cold: mycoplasma pneumonia, mononucleosis, lymphoma |
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A-39. Megablastic amemia is caused by decreased DNA synthesis due to...?
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Vitamin B12 and Folate deficiency
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A-39. Pathophys and clinical presentation of Plummer-Vinson anemia?
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Path: low grade, long-term iron deficiency
Sx: esophageal webs that leads to dysphagia for solids, not liquids |
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A-39. What are the two causes of neutropenia (decreased neutrophils)?
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1.) Decreased production
2.) Increased destruction |
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A-39. What can cause neutrocytosis (neutrophilia)?
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Acute inflammation/infection, bacterial infection, luekemia of neutrophils and certain cancers
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A-39. Auer rods are associated with?
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AML
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A-39. What are signs and symotoms of Non-Hodgkins Lymphoma?
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Wide spread adenopathy, hypercalcemia, hepatosplenomegaly, spreads to multiple nodes, and neutrocytosis
-Prob. viral etiology associated with bcl-2 |
