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18 Cards in this Set
- Front
- Back
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physiology of erection?
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increased atrial flow + decreased venous overflow= erection.....subsides when cGMP removed
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Must have what for ED meds to work?
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sexual arousal
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ED can be 1st sign of what health condition (in men)?
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cardiovascular disease
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Sildenafil (Viagra) MOA?
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Selection inhibition of the enzyme that preserves cGMP levels
Erection harder and longer lasting Still have to have sexual stimuli |
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Sildenafil (Viagra) Peak:
fasting, after meal, half life? |
Peak in 60 minutes in fasting
2 hours after a meal 4 hour half life |
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Sildenafil (Viagra)
metabolized where? |
liver
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Sildenafil (Viagra)
Adverse effects? |
hypotension and priapism (erection >6 hours)
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Sildenafil (Viagra)
Interactions? |
nitrates (hypotension)
Alpha blockers (postural hypotension) Inhibitors of CYP3A4 (can increase Viagra levels) i.e. grapefruit juice, erythromycin |
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Sildenafil (Viagra)
Caution with recent hx of? |
MI, stroke, dysrhythmia, Hypotension, hypertension, heart failure, unstable angina
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Benign Prostatic Hyperplasia
Symptoms? |
Urinary “issues” hesitancy, urgency, increased frequency etc
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BPH
2 pharm treatment (classes)? |
5-Allpha-Reductase Inhibitors
Alpha-Adrenergic Antagonists (A-blockers) |
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BPH drug
5-Allpha-Reductase Inhibitors Example? |
Finasteride (Proscar)
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5-Allpha-Reductase Inhibitors: Finasteride (Proscar)
MOA? |
promotes regression of prostate epithelial tissue,
Decreases mechanical obstruction of the urethra |
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Finasteride (Proscar)
Side effects? |
Generally well tolerated
Can decrease ejaculate volume and libido in 5-10% Also gynecomastia Decreases PSA by 30-50%; if levels do not fall, eval for cancer |
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BPH Drug:
Alpha-Adrenergic Antagonists (A-blockers) Examples? |
Hytrin, Cardura, Flomax, Uroxatral
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Alpha-Adrenergic Antagonists (A-blockers)
MOA? |
Relaxes smooth muscle in the bladder neck, prostate capsule and
urethra Decreases dynamic obstruction of the urethra For relatively mild enlargement |
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Alpha-Adrenergic Antagonists
Adverse effects? |
hypotension, fainting dizziness, somnolence, nasal congestion
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A-Adrenergic Antagonists (A-blockers)
Drug Interactions? |
Anti-hypertensives, nitrates, Viagra
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