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91 Cards in this Set
- Front
- Back
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If a 19-year-old man takes an overdose of phenobarbital (a weak organic acid), which of the following will enhance its renal elimination?
Answer acetazolamide (Diamox) N-acetylcysteine (Acetadote) ammonium chloride cholestyramine (Questran) fomepizole (Antizol) |
acetazolamide (Diamox)
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In a 76-year-old man whose renal function is reduced by 40 percent, for which of the following drugs is it most important to reduce the dose?
Answer acetaminophen azithromycin (Zithromax) doxycycline (Vibramycin) gentamicin (Garamycin) warfarin (Coumadin) |
gentamicin (Garamycin)
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A 29-year-old woman is infected simultaneously with Treponema pallidum, Neisseria gonorrhoeae, and Chlamydia trachomatis. Which of the following would be most effective for all 3 of these sexually transmitted microbes?
Answer amoxicillin (Amoxil) cefaclor (Ceclor) doxycycline (Vibramycin) fluconazole (Diflucan) gentamicin (Garamycin) |
doxycycline (Vibramycin)
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A 36-year-old woman with cellulitis experienced anaphylaxis after receiving amoxicillin 2 years ago. Which of the following antibiotics should be avoided for the treatment of cellulitis in this patient?
Answer aztreonam (Azactam) cefuroxime (Cefzil) gentamicin (Garamycin) ciprofloxacin (Cipro) vancomycin (Vancocin) |
cefuroxime (Cefzil)
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Which of the following is appropriate chronic therapy for a 59-year-old man with a 6-year history of frequent, recurrent, and very painful kidney stones?
Answer eplerenone (Inspra) furosemide (Lasix) hydrochlorothiazide (Esidrix) meperidine (Demerol) probenecid (Benemid) |
hydrochlorothiazide (Esidrix)
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A 55-year-old man with Mycoplasma pneumoniae is treated with azithromycin. Azithromycin has the following properties:
- Urinary excretion = 10% - Bioavailability = 35% - Clearance = 35L/h - Volume of distribution = 2500 L - The calculated half-life of azithromycin is about: Answer 10 h 25 h 50 h 75 h 100 h |
50 h
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A 32-year-old heroin addict was brought to the Emergency Department with a broken leg. He required a dose of morphine that was 5-times larger than typically used to relieve pain in a non-addicted patient. Which of the following best describes this situation?
Answer competitive antagonism pharmacodynamic tolerance pharmacokinetic tolerance physiological antagonism supersensitivity |
pharmacodynamic tolerance
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A 3-year-old girl was brought to the Emergency Department in a comatose state after drinking a substance found in a garage. She was found to have calcium oxylate crystals in her urine. Which of the following would be an appropriate antidote for this young girl?
Answer N-acetylcysteine (Acetadote) deferoxamine (Desferal) fomepizole (Antizol) methylene blue succimer (Chemet) |
fomepizole (Antizol)
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An Emergency Medicine Applicant for residency was being quizzed by an attending on the treatments of poisons. Which one of the following poisons is improperly matched with the indicated treatment or antidote?
Answer organophosphate pesticide - atropine carbon monoxide - oxygen cyanide - amyl nitrite lead - methylene blue acetaminophen - N-acetylcysteine (Acetadote) |
lead - methylene blue
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A 53-year-old man who attempted suicide was brought to the Emergency Department with symptoms of coma, dry skin and mucous membranes, and dilated pupils. Sinus tachycardia was present, and the QT intervals were prolonged. Three hours after hospitalization, recurrent and persistent seizures occurred, which were treated with diazepam (Valium) and pancuronium (Pavulon). In addition to supportive therapy, he was given sodium bicarbonate. This individual most likely took an overdose of:
Answer acetaminophen (Tylenol) amitriptyline (Elavil) lithium nifedipine (Procardia) propranolol (Inderal) |
amitriptyline (Elavil)
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A 65-year-old man with diabetes and congestive heart failure is being managed with several drugs. Which of his medications is most likely responsible for causing hypokalemia?
Answer digoxin (Lanoxin) enalapril (Vasotec) furosemide (Lasix) metformin (Glucophage) spironolactone (Aldactone) |
furosemide (Lasix)
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Which of the following drug combinations would be appropriate for the treatment of an 80-year-old man with a previous history of heart disease, markedly swollen ankles, and extreme breathing difficulty even at rest?
Answer hydrochlorothiazide (Esidrix), digoxin (Lanoxin), and mannitol (Osmitrol) furosemide (Lasix), lisinopril (Prinivil), and digoxin furosemide, quinidine (Quinora), and verapamil (Calan) furosemide, triamterene (Dyrenium), and procainamide (Pronestyl) lisinopril, digoxin, and mannitol |
furosemide (Lasix), lisinopril (Prinivil), and digoxin
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Untoward side-effect of quinidine (Quinora) would include which of the following:
Answer decreased plasma digoxin levels causing reduced toxicity of digoxin lupus erythematosus-like syndrome in susceptible individuals paradoxical ventricular bradycardia syncope due to Torsades de pointes constipation |
syncope due to Torsades de pointes
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Which of the following drugs is most appropriate for treatment of a life-threatening ventricular arrhythmia in a 59-year-old man with severe chronic obstructive pulmonary disease (COPD)?
Answer adenosine (Adenocard) amiodarone (Cordarone) esmolol (Brevibloc) lidocaine (Xylocaine) verapamil (Calan) |
lidocaine (Xylocaine)
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Which of the following is the drug of choice for treatment of a 64-year-old man with paroxysmal supraventricular tachycardia?
Answer adenosine (Adenocard) lidocaine (Xylocaine) sotalol (Betapace) procainamide (Pronestyl) propranolol (Inderal) |
adenosine (Adenocard)
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Which of the following antihypertensive drugs may increase hair growth and induce anginal attacks?
Answer verapamil (Calan) doxazosin (Cardura) minoxidil (Loniten) enalapril (Vasotec) losartan (Cozaar) |
minoxidil (Loniten)
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Which of the following is a logical drug combination for chronic treatment of hypertension in a 65-year-old woman?
Answer hydrochlorothiazide (Esidrix) and sodium nitroprusside (Nitropress) hydralazine (Apresoline) and minoxidil (Loniten) hydrochlorothiazide and spironolactone (Aldactone) indapamide (Lozol) and furosemide (Lasix) verapamil (Calan) and diltiazem (Cardizem) |
hydrochlorothiazide and spironolactone (Aldactone)
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A patient being treated for hypertension complains of dry cough, and laboratory results show hyperkalemia. Which of the following classes of anti-hypertensive drugs is most likely to produce these effects?
Answer alpha adrenergic antagonists angiotensin converting enzyme inhibitors sodium channel blockers beta adrenergic antagonists calcium channel blockers |
angiotensin converting enzyme inhibitors
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Antihypertensive drug that lowers blood pressure by blocking angiotensin receptors (AT1) competitively:
Answer propranolol (Inderal) nifedipine (Procardia) enalapril (Vasotec) losartan (Cozaar) amiodarone (Cordarone) |
losartan (Cozaar)
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A 47-year-old woman with blood pressure of 148/99 mmHg was treated with monotherapy. Which of the following drugs would lower blood pressure by blocking calcium channels?
Answer propranolol (Inderal) losartan (Cozaar) hydrochlorothiazide (Esidrix) enalapril (Vasotec) verapamil (Calan) |
verapamil (Calan)
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This drug has the greatest potential to increase gallstone formation:
Answer cholestyramine (Questran) probucol (Lorelco) gemfibrozil (Lopid) niacin (nicotinic acid) lovastatin (Mevacor) |
gemfibrozil (Lopid)
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The drug of choice for treatment of acute anginal attacks is:
Answer nitroglycerin verapamil (Calan) doxazosin (Cardura) propranolol (Inderal) enalapril (Vasotec) |
nitroglycerin
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Which of the following can prevent angina pectoris by decreasing myocardial work but may precipitate congestive heart failure?
Answer methyldopa (Aldomet) methyldopa (Aldomet) metoprolol (Lopressor) metolazone (Mykrox) inamrinone (Inocor) |
metoprolol (Lopressor)
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Most suitable drug for the treatment of pain in terminal cancer:
Answer loperamide (Imodium) meperidine (Demerol) morphine codeine amitriptyline (Elavil) |
morphine
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Which of the following drugs is classified as a pure opioid antagonist?
Answer disulfiram (Antabuse) naloxone (Narcan) fomepizole (Antizol) pentazocine (Talwin) flumazenil (Romazicon) |
naloxone (Narcan)
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Primary cause of death in opioid overdose:
Answer stroke cardiac failure hepatotoxicity renal failure respiratory depression |
respiratory depression
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Which of the following INCORRECTLY matches a drug with its principal target site?
Answer aspirin: cyclooxygenase allopurinol (Zyloprim): xanthine oxidase colchicine: tubulin indomethacin (Indocin): cyclooxygenase probenecid (Benemid): dihydrofolate reductase |
probenecid (Benemid): dihydrofolate reductase
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Which of the following statements about acetaminophen is FALSE?
Answer it is activated by cytochrome P450 to an hepatotoxic metabolite it is as effective as aspirin as an analgesic and antipyretic it is as effective as aspirin as an anti-inflammatory agent its toxicity may be potentiated by prior alcohol consumption an overdose is treated with N-acetylcysteine (Acetadote) |
it is as effective as aspirin as an anti-inflammatory agent
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Which of the following drugs binds primarily to cyclooxygenase-2 (COX-2)?
Answer celecoxib (Celebrex) allopurinol (Zyloprim) piroxicam (Feldene) diclofenac (Voltaren) ibuprofen (Motrin) |
celecoxib (Celebrex)
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Which of the following drugs is expected to have the LEAST effect on the renal excretion of uric acid?
Answer furosemide (Lasix) probenecid (Benemid) sumatriptan (Imitrex) ethacrynic acid (Edecrin) aspirin |
sumatriptan (Imitrex)
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This drug binds to and inactivates tumor necrosis factor (TNFalpha):
Answer sulfasalazine (Azulfidine) mycophenolate mofetil (Cellcept) infliximab (Remicade) leflunomide (Arava) penicillamine (Cuprimine) |
infliximab (Remicade)
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Insulin induced hypoglycemia produces:
Answer sweating cardiac palpitation (exrasystoles or tachycardia) confusion and disorientation hunger, nausea all of the above |
all of the above
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Hypoglycemic efficacy of the sulfonylureas in the treatment of type 2 diabetes mellitus depends on the:
Answer liver anterior pituitary gland alpha-cells of the pancreatic islets beta-cells of the pancreatic islets hypothalamus |
beta-cells of the pancreatic islets
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Indicated for parenteral use in severe diabetic ketoacidosis:
Answer ultralente insulin regular insulin lente insulin NPH insulin mixed NPH and regular insulin |
regular insulin
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Select the correct drug -- adverse effect pair.
Answer metformin (Glucophage) -- hypoglycemia pioglitazone (Actos) -- bone marrow damage tolbutamide (Orinase) -- hypoglycemia insulin -- weight loss glyburide (Micronase) -- gastric ulceration |
tolbutamide (Orinase) -- hypoglycemia
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Both ergonovine (Ergotrate) and oxytocin (Pitocin):
Answer are used to induce abortion are used only by nasal instillation effectively control postpartum hemorrhage stimulate milk "let down" cause systemic vasodilation |
effectively control postpartum hemorrhage
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Macrolide antibiotics (e.g. erythromycin) should not be combined with penicillin in the treatment of a bacterial infection because they antagonize the therapeutic effect of penicillins by:
Answer decreasing the GI absorption of penicillins increasing the renal excretion of penicillin increasing the glomerular filtration of penicillins inhibiting the growth of bacteria altering the tissue penetration of penicillins |
inhibiting the growth of bacteria
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The use of extended and broad spectrum antibiotics (e.g. tetracyclines, clindamycin) may result in:
Answer intestinal candidiasis pseudomembranous colitis superinfections development of resistance all of the above |
all of the above
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Most important and most frequently seen side effect of the aminoglycosides:
Answer allergy nephrotoxicity hepatotoxicity GI disturbances cardiomyopathy |
nephrotoxicity
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Tetracycline therapy is effective against a broad spectrum of organisms; however, it should be used cautiously if at all in:
Answer geriatric patients patients awaiting surgery patients taking MAO inhibitors pregnant women young adults |
pregnant women
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A 28-year-old female patient had been treated with tetracycline for 2 weeks because of a Mycoplasma pneumoniae infection. At the end of the treatment period she developed oral candidiasis (thrush). Which of the following drugs would be suitable for the treatment of this infection?
Answer paromomycin (Humatin) nystatin (Mycostatin) ivermectin (Mectizan) niclosamide (Niclocide) metronidazole (Flagyl) |
nystatin (Mycostatin)
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Ethambutol (Myambutal), rifampin (Rimactane) and pyrazinamide (Aldinamide) are administered concurrently with isoniazid (INH) in the treatment of tuberculosis in order to:
Answer reduce the pain of injection facilitate penetration of the blood brain barrier minimize the development of organisms resistant to isoniazid delay excretion of isoniazid by the kidney retard absorption after intramuscular injection |
minimize the development of organisms resistant to isoniazid
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Which of the following drugs binds reversibly to 50S ribosomes?
Answer cycloserine (Seromycin) ceftriaxone (Rocephin) chloramphenicol (Chloromycetin) gentamicin (Garamycin) sulfamethoxazole (Gantanol) |
chloramphenicol (Chloromycetin)
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The most important adverse effect of vancomycin (Vancocin) is:
Answer nephrotoxicity hepatotoxicity seizures hypersensitivity reactions pseudomembranous colitis |
nephrotoxicity
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The most important adverse effect of penicillin G (Pfizerpen) is:
Answer nephrotoxicity hepatotoxicity seizures hypersensitivity reactions pseudomembranous colitis |
hypersensitivity reactions
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ne morning as you are watching the TV news you hear an ad for a new drug. The ad says that the side effects of the drug include dry mouth, blurred vision, and constipation. Men with benign prostatic hyperplasia, and people with glaucoma, should not take this drug. Based on this information, you conclude that the drug probably:
Answer Blocks dopamine D2 receptors Blocks alpha1 receptors Blocks muscarinic receptors Inhibits reuptake of dopamine and norepinephrine Blocks beta2 receptors |
Blocks muscarinic receptors
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A new drug is being tested in anesthetized animals. The drug decreased the heart rate. If the animals were pretreated with neostigmine (Prostigmin), the drug caused a larger decrease in heart rate. If the animals were pretreated with atropine, the drug had no effect. The new drug is most likely similar to which of the following?
Answer Epinephrine (Adrenalin) Acetylcholine Tolterodine (Detrol) Nicotine Propranolol (Inderal) |
Acetylcholine
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Which combination of receptor: effect is CORRECT?
Answer Alpha1 (α1): vasoconstriction Alpha2 (α2): increased heart rate and blood pressure Beta1 (β1): decreased heart rate Beta2 (β2): bronchoconstriction Muscarinic: mydriasis |
Alpha1 (α1): vasoconstriction
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A worker is exposed to an unknown powder in an agricultural setting. He comes to the emergency room with difficulty breathing, bradycardia, excessive salivation, diarrhea, cramping and blurred vision. What statement about this situation is CORRECT?
Answer He should be treated with prasozin (Minipres) to increase his heart rate and increase cardiac output He should be treated with epinephrine (Adrenalin) and diphenhydramine (Benadryl) to block histamine receptors He should be treated with propranolol (Inderal) to reduce bronchoconstriction He should be treated with atropine and pralidoxime (PAM) to block muscarinic receptors and prevent enzyme aging He should be treated with pilocarpine (Pilocar) to decrease salivation and diarrhea |
He should be treated with atropine and pralidoxime (PAM) to block muscarinic receptors and prevent enzyme aging
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A 69 year-old man complains of difficulty urinating. Physical examination shows enlargement of the prostate. His blood pressure is also elevated, at 160/100 mm Hg. He is given a drug that is effective for both of his problems, although he experiences dizziness the first time he takes it. What is the drug most likely to be?
Answer Finasteride (Proscar) Atropine Prasozin (Minpress) Propranolol (Inderal) Nifedipine ((Procardia) |
Prasozin (Minpress)
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One of your patients is a 68 year-old man with type I diabetes. He has had several episodes of hypoglycemia, for which he carries glucose tablets. Now he needs to be treated for hypertension. Which of the following drugs is LEAST appropriate for treatment of this patient?
Answer Prazosin (Minipress) Metoprolol (Lopressor) Propranolol (Inderal) Losartan (Cozaar) Nifedipine ((Procardia) |
Propranolol (Inderal)
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A 55 year-old man with asthma needs to be treated for glaucoma. Which of the following will be LEAST suitable for this patient?
Answer Pilocarpine (Isoptocarpine) Timolol (Timoptic) Betaxolol (Betopic) Brimonidine (Alphagan) Acetazolamide (Diamox) |
Timolol (Timoptic)
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Short acting drug commonly used for diagnosis of myasthenia gravis:
Answer Edrophonium (Tensilon) Vecuronium (Norcuron) Esmolol (Brevibloc) Isoproterenol (Isuprel) Succinylcholine (Anectine) |
Edrophonium (Tensilon)
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Causes non-depolarizing blockade of the neuromuscular junction that is reversed with neostigmine (Prostigmin):
Answer Edrophonium (Tensilon) Vecuronium (Norcuron) Esmolol (Brevibloc) Isoproterenol (Isuprel) Succinylcholine (Anectine) |
Vecuronium (Norcuron)
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Effects of epinephrine include all EXCEPT:
Answer Positive inotropic and chronotropic effect in the heart Vasoconstriction Strong reflex slowing of the heart rate Bronchodilation Tremor |
Strong reflex slowing of the heart rate
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Clonidine (Catapres):
Answer Inhibits reuptake of norepinephrine into nerve terminals in the brain Is an alpha2 agonist used in treatment of hypertension Blocks both alpha and beta receptors May cause agranulocytosis Is an alpha1 agonist used primarily as a decongestant |
Is an alpha2 agonist used in treatment of hypertension
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Rapid withdrawal after chronic high-level alcohol ingestion is often associated with hyperactivity of the brain and seizures. What is a likely mechanism?
Answer Down-regulation of GABAA receptors Induction of aldehyde dehydrogenase Inhibition of the microsomal ethanol oxidizing system Decreased sensitivity of NMDA receptors Increased release of serotonin |
Down-regulation of GABAA receptors
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Which of the following drugs is LEAST likely to increase the incidence of seizures?
Answer Chlorpromazine (Thorazine) Amitriptyline (Elavil) Buspirone (BuSpar) Bupropion (Wellbutrin) Meperidine (Demerol) |
Buspirone (BuSpar)
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A patient taking a medication complains of lightheadedness when he stands up quickly. Which of the following drugs is LEAST likely to produce postural hypotension?
Answer Fluoxetine (Prozac) Chlorpromazine (Thorazine) Amitriptyline (Elavil) Prazosin (Minipres) Risperidone (Risperdal) |
Fluoxetine (Prozac)
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Which of the following is a common side effect of fluoxetine (Prozac)?
Answer Dry mouth and urinary retention Sexual dysfunction Tardive dyskinesia Gingival hyperplasia Torsades de pointes |
Sexual dysfunction
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Dantrolene (Dantrium) is given to a patient in the emergency room. Which of the following drugs is LEAST likely to cause the symptoms treated by dantrolene?
Answer Haloperidol (Haldol) Succinylcholine (Anectine) Halothane (Fluothane) Chlorpromazine (Thorazine) Diazepam (Valium) |
Diazepam (Valium)
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Blocks D2 and 5HT2A receptors; considered drug of choice for treatment of schizophrenia:
Answer Fluoxetine (Prozac) Risperidone (Risperdal) Lithium (Eskalith) Aripiprazole (Abilify) Chlorpromazine (Thorazine) |
Risperidone (Risperdal)
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Inhibits reuptake of dopamine, useful in depression which hasn t responded to other drugs:
Answer Aripiprazole (Abilify) Fluoxetine (Prozac) Bupropion (Wellbutrin) Escitalopram (Lexapro) Buspirone (BuSpar) |
Bupropion (Wellbutrin)
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Used for treatment of anxiety, partial agonist at 5HT1A receptors, and will NOT prevent alcohol withdrawal symptoms:
Answer Aripiprazole (Abilify) Fluoxetine (Prozac) Bupropion (Wellbutrin) Diazepam (Valium) Buspirone (BuSpar) |
Buspirone (BuSpar)
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A 22 year-old man has become increasingly anxious and irritable, which his family attributes to his difficulty sleeping. One night he is brought into the emergency room by his friends after he started screaming that people were attacking him with giant parrots. His blood pressure is 195/110 mm Hg, pupils are dilated, and his heart rate is 135 bpm. Another noticeable finding is the presence of round cuts on his arms and legs. You ask about them, and he tells you he was cutting out bugs. You suspect drug abuse. What drug is MOST likely to have caused these particular symptoms?
Answer Alcohol Carisprodol (Soma) Heroin Cocaine MDMA (Ecstacy) |
Cocaine
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Withdrawal from this drug of abuse is severe and may be life-threatening, and should be prevented with long-acting benzodiazepines:
Answer Alcohol Methamphetamine Heroin Cocaine MDMA (Ecstasy) |
Alcohol
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Which of the following statements regarding l-dopa/carbidopa (Sinemet) is CORRECT?
Answer Addition of carbidopa will decrease the CNS effects of l-dopa It is effective in the treatment of malignant melanoma Its effectiveness will improve with time Administration in divided doses may decrease nausea A common side effect is red, swollen, painful feet |
Administration in divided doses may decrease nausea
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Respiratory depression following the use of this drug in a general anesthesia regimen may be reversed by flumazenil (Mazicon):
Answer Propofol (Diprivan) Isoflurane (Forane) Fentanyl (Sublimaze) Midazolam (Versed) Nitrous oxide |
Midazolam (Versed)
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A patient has an allergic reaction during surgery. Which of the following anesthetic agents is MOST likely to have caused this problem?
Answer Propofol (Diprivan) Isoflurane (Forane) Halothane (Fluothane) Midazolam (Versed) Nitrous oxide |
Propofol (Diprivan)
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Useful for treatment of diarrhea:
Answer Magnesium hydroxide (Milk of Magnesia) Tegaserod (Zelnorm) Metoclopramide (Reglan) Esomeprazole (Nexium) Loperamide (Imodium) |
Loperamide (Imodium)
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A 46 year-old man develops a deep vein thrombosis after a surgery. He is treated with a 6 month course of warfarin (Coumadin) to prevent any further problems. During this time period, he developed heartburn, which he treated with an over the counter medication. Two weeks later he came to your office. He had several bruises, and his INR had increased from the desired 2.5 to 4. Which of the following medications is MOST likely to have caused this effect?
Answer Ranitidine (Zantac) Cimetidine (Tagamet) Aluminum/magnesium hydroxide (Maalox) Pantoprazole (Protonix) Misoprostol (Cytotec) |
Cimetidine (Tagamet)
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Useful in the treatment of asthma because it blocks leukotriene receptors:
Answer Albuterol (Ventolin) Salmeterol (Serevent) Montelukast (Singulair) Theophylline (Theo-Dur) Ipratropium (Atrovent) |
Montelukast (Singulair)
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A 29 year-old woman with chronic asthma develops Graves disease. She is 2 months pregnant. Of the following, which drug would you use to treat the Graves disease?
Answer Propranolol (Inderal) Propylthiouracil (PTU) Methylthiouracil (Methimazole) Radioactive Iodine (I131) Levothyroxine (Synthroid) |
Propylthiouracil (PTU)
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Blocks H1 receptors but causes little sedation because it doesn't cross the blood brain barrier:
Answer Diphenhydramine (Benadryl) Cimetidine (Tagamet) Amitriptyline (Elavil) Loratidine (Claritin) Albuterol (Ventolin) |
Loratidine (Claritin)
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Treatment of choice for cytomegalovirus, but may cause neutropenia:
Answer Acyclovir (Zovirax) Zidovudine (Retrovir) Ribavirin (Rebetron) Gancliclovir (Cytovene) Saquinavir (Invirase) |
Gancliclovir (Cytovene)
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Drugs that induce CYP3A may cause this drug to be ineffective:
Answer Acyclovir (Zovirax) Zidovudine (Retrovir) Ribavirin (Rebetron) Gancliclovir (Cytovene) Saquinavir (Invirase) |
Saquinavir (Invirase)
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May be used to prevent transmission of HIV from a pregnant woman to the fetus:
Answer Acyclovir (Zovirax) Zidovudine (Retrovir) Ribavirin (Rebetron) Gancliclovir (Cytovene) Saquinavir (Invirase) |
Zidovudine (Retrovir)
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Mechanism of action of cyclosporine (Sandimmune):
Answer Inhibits reverse transcriptase Binds to CD3 receptor on activated T-cell Decreases production of TNFα Inhibits calcineurin, preventing activation of T-cells Increases activity of macrophages and B cells |
Inhibits calcineurin, preventing activation of T-cells
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Inhibits inosine monophosphate dehydrogenase, needed for de novo purine synthesis in T and B cells, and has a mild side effect profile:
Answer Interferon alfa 2b Azathioprine (Imuran) Cyclosporine (Sandimmune) Muromonab-CD3 (Orthoclone) Mycophenolate Mofetil (CellCept) |
Mycophenolate Mofetil (CellCept)
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A 25-year-old woman with clotting factor V Leiden mutation is being treated with an oral anticoagulant but she wishes to become pregnant and start a family. Which of the following drugs would be the best choice for continued management of her thrombophilia during pregnancy?
Answer Warfarin (Coumadin) Abciximab (ReoPro) Enoxaparin (Lovenox) Ticlopidine (Ticlid) Reteplase (Retavase) |
Enoxaparin (Lovenox)
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A 10-year-old boy suffers from frequent episodes of absence seizures. Despite several attempts to begin therapy with ethosuximide (Zarontin), severe gastric pain has prevented its use in this patient. Which of the following would be the best choice to treat this patient s seizures?
Answer Carbamazepine (Tegretol) Clonazepam (Klonopin) Gabapentin (Neurontin) Phenytoin (Dilantin) Valproic acid (Depakene) |
Valproic acid (Depakene)
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Which of the following is the best choice for treating toxoplasmosis?
Answer Pyrimethamine (Daraprim), sulfadiazine, & folinic acid Tetracycline Azithromycin (Zithromax) Paromomycin (Humatin) Metronidazole (Flagyl) |
Pyrimethamine (Daraprim), sulfadiazine, & folinic acid
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Which of the following drugs is the best choice for treating an infection with the nematode Trichuris trichiura (whipworm), but is considered teratogenic and is not suitable for use during pregnancy?
Answer Paromomycin (Humatin) Mebendazole (Vermox) Trimethoprim plus sulfamethoxazole (Bactrim) Ivermectin (Mectizan) Praziquatel (Biltricide) |
Mebendazole (Vermox)
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A 30-year-old man returns from traveling in the jungles of Borneo and arrives unconscious in the emergency room after collapsing at home. He has a high fever, and laboratory results indicate a severe infection with Plasmodium falciparum. Which of the following is the best choice for immediate treatment of this patient?
Answer Chloroquine (Aralen) Mefloquine (Lariam) Atovaquone + proguanil (Malarone) Quinidine gluconate or quinine sulfate Primaquine |
Quinidine gluconate or quinine sulfate
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A 28-year-old man is diagnosed with testicular cancer. Which of the following drugs is used to treat this type of cancer and is LEAST likely to cause myelosuppression?
Answer Vinblastine (Velban) Etoposide (Vepesid) Cisplatin (Platinol) Methotrexate Cyclophosphamide (Cytoxan) |
Cisplatin (Platinol)
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Which of the following drugs is used to treat lung carcinoma and works by inhibiting disassembly of microtubules?
Answer Paclitaxel (Taxol) Methotrexate Cisplatin (Platinol) Doxorubicin (Adriamycin) 5-Fluorouracil (Adrucil) |
Paclitaxel (Taxol)
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A 30-year-old woman asks her doctor about oral contraceptives. She smokes and has poorly controlled hypertension. Which of the following would be the most serious side effect of using estrogens in this patient?
Answer Stroke Breast cancer Uterine hyperplasia Hepatotoxicity Osteoporosis |
Stroke
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A 30-year-old woman with a 5-year history of endometriosis presents complaining of severe pelvic pain. Laparoscopy confirms progression of her disease. Which of the following would be the best choice to treat her endometriosis?
Answer Flutamide (Eulexin) Finasteride (Proscar) Danazol (Danocrine) Methyltestosterone Tamoxifen (Nolvadex) |
Danazol (Danocrine)
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An asthma patient with poorly controlled disease has been forced to rely on oral corticosteroids for the last 15 years. Which of the following is the most serious side effect of long-term glucocorticoid therapy?
Answer Tolerance Hyperglycemia Sodium and water retention Osteoporosis Congestive heart failure |
Osteoporosis
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A peptic ulcer is diagnosed in a 55-year-old man and is successfully treated with esomeprazole (Nexium). Which of the following drugs might have precipitated the formation of the ulcer in this patient?
Answer Simvastatin (Zocor) Penicillin G Warfarin (Coumadin) Bleomycin (Blenoxane) Methylprednisolone (Medrol) |
Methylprednisolone (Medrol)
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A 12-year-old boy is brought to the emergency room after crashing on his bicycle. Which of the following is the best choice to provide local anesthesia while suturing his wounds?
Answer Lidocaine (Xylocaine) Bupivicaine (Marcaine) Ropivicaine (Naropin) Cocaine Benzocaine (Americaine) |
Lidocaine (Xylocaine)
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