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15 Cards in this Set
- Front
- Back
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What are skeletal muscle relaxants used for in general?
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Reducing muscle tone associated w/ spasticity in musculoskeletal disorders
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What condition is often associated with spasticity?
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Multiple sclerosis
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What is Spasticity characterized by?
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-Increased tonic stretch reflexes
-Increased flexor muscle spasms -Possible muscle weakness |
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What 2 sites are involved in the mechanisms underlying spasticity?
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-Stretch reflex arc
-Higher brain centers |
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What are the 3 main drugs used for treating muscle spasticity?
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-Diazepam
-Baclofen -Tizanidine |
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Where is the target site of action of Diazepam and Baclofen?
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In the spinal cord LMNs
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What is the mechanism of action of Diazepam?
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Facilites GABA-mediated presynaptic inhibition of LMNs.
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What is the mechanism of action of Baclofen?
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Agonist at GABA-B receptors causing hyperpolarization and presynaptic inhibition of Glutamine release
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Why is Baclofen used more often than Diazepam as a muscle relaxant?
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Because it causes less sedation but is just as effective as Diazepam
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What is Tizanidine? What is it related to?
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An a2-agonist related to Clonidine
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What is the mechanism of Tizanidine in how it relaxes skeletal muscle?
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It enhances presynaptic and postsynaptic inhibition
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What are 4 side effects of Tizanidine?
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-Hypotension
-Asthenia -Dry mouth -Drowsiness |
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What is the reason for using Diazepam less for treating sk muscle spasms?
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It produces sedation in most patients at the doses required to reduce muscle tone.
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What drug is an antagonist of the Benzodiazepine receptor?
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Flumazenil
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What can Flumazenil be used for?
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Reversing the effects of benzodiazepines
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