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26 Cards in this Set
- Front
- Back
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Predominant primary organ involved in lymphoma
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lymphatic tissues
(instead of bone marrow) |
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What are the two main types of lymphomas?
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Hodgkin's and Non-Hodgkins
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Hodgkin's Lymphoma:
Malignant cell is Reed- Sterberg Cell which is a _-cell Bulk of tumor is _____ tissue Spreads continguously from ____ to ____ |
B
reactive node to node |
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Which kind of lymphoma is this?
Localization depends on cell of origin Spreads hematgoneously |
Non-Hodgkin's
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Hodgkin's lymphoma is more prevalent in what age range?
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15-20
increases again around 65-70 |
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HL is highly curable with ________ and/or _______
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chemo
radiation |
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Determine therapy based on stage:
localized disease treated with local therapy: ___ Widespread disease treated wih systemic therapy: _________ Bulky localized disease: ________ with or without ______ |
XRT
chemotherapy chemo radiation |
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Stage I: ____ nodal group(s)
Stage II: ______ nodal group(s) Stage III: nodal groups on both sides of _______ Stage IV: Marrow or ___ involvement |
single
multiple diaphragm CNS |
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In the stages of HL:
A = what? B = what? |
asymptoms
symptoms (fever, night sweats, weight loss) |
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What is a common symptom of lymphoma that resolves within the first cycle of chemo, but reappears with remission
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Pruritis
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Second malignancy is a ____ tumor, which kind is most common?
You can also have secondary ______ |
solid
lung or breast cancer from radiation on chest leukemia |
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Third cause of death after HL and second malignancies is what?
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cardiac mortality - most commonly acute MI due to CAD. Associated with mediastinal XRT
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Used to take out _____ of Hodgkin's pts, not they don't because of ________________
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hypogammaglobulinemia from therapy
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Pulmonary complications from therapy range from acute interstitial _________ to chronic lung injury
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penumonitis (radiation)
bleomycin |
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Non-Hodgkin's Lymphoma most commonly of _-cell origin in the Western population but may be from _-cell origin in far east, Asian.
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B
T |
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Low grade NHL is _____lymphomas, small lymphocytic.
Intermediate are diffuse ____ cell Aggressive is called _____ caused by what virus? |
follicular
large Burkitt's |
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NHL classified by whether they are mature _ or _ ____ neoplasms
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B or T-cell
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Mature B-cell neoplasms:
Follicular, _____ cell, Diffuse _____ cell, Burktt's, MALT (caused by ______) |
mantle
large H. pylori |
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Mature T-Cell neoplasms:
Mycosis fungoides, ______ T-cell, _______ large cell |
peripheral
anaplastic |
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Which type of NHL is treatable?
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Immediate/aggressive because it divides fast. Like Burkitt's/diffuse large cell
low grade are indolent but incurable |
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For NHL, don't treat unless forced to and use as little therapy as possible (______ alone, monoclonal ____therapy)
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radiation
antibody |
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What combination cytotoxic is used for aggressive lymphoma therapy?
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R-CHOP
XRT if localized |
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What is a targeted therapy for NHL?
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Rituximab: anti-CD20
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NHL treatment includes ___ ____ transplant which allows more aggressive therapy. If __genic get immune attack as well
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stem cell
allogenic |
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Combination chemotherapy is _____ x _ cycles
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R-CHOP
3 |
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Key difference betweeh HD and NHL:
Hodkin's spreads through _____ therapy determined by ____ NHL spreads through ____ therapy determined by ____type |
lymphatics
stage blood cell type |
