Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
33 Cards in this Set
- Front
- Back
|
morphine
|
low oral, high first pass, enters CNS slowly
coma, miosis, resp depression don't use w/ TBI - increases intracranial pressure, asthma, hepatic, renal dz |
|
|
methadone
|
85% oral
withdrawal milder but longer cross tolerance with heroin |
|
|
meperidine
|
50% oral
normeperidine is anticonvulsant - builds up never use with MAOI anti-Ach - tachycardia less smooth muscle effects, no effects on labor or baby |
|
|
heroin
|
rapidly enters brain - short euphoria
|
|
|
fentanyl
|
100X more potent
rapid onset, short acting anasthesia teratogenic |
|
|
oxycodone
|
oral, oxycontin
+tylonol=percocent oxymorphone by o-demethylation - more potent than morphine and euphoric |
|
|
propoxyphene
|
oral, weak mu agonist
delusions, hallucinations, irritation at injection low abuse potential |
|
|
codeine
|
oral
prodrug, 10% converted to morphine by CYP 10% whites cant metabolize antitussive |
|
|
tramadol
|
oral
GABA, NE, 5HT effects 10% -> morphine when given IV contraindicated w/ SSRI |
|
|
pentazocine
|
kappa agonist, partial mu agonist
oral has nalozone ceiling effect, may precipitate withdrawal |
|
|
nalbuphine
|
like pentazocine
|
|
|
butorphanol
|
like pentazocine
|
|
|
buprenorphine
|
partial mu agonist with t=37h
ceiling effect alternative to methadone |
|
|
dextromethorphan
|
antitussive opioid
contra w/ MAOI - convulsant metabolite |
|
|
diphenoxylate
|
w/ atropine
anti-diarrhea opioid |
|
|
loperamide
|
immodium - anti-diarrhea opioid
|
|
|
naloxone
|
IV opioid antagonist
not absorbed orally |
|
|
naltrexone
|
oral opioid antagonist with long half life
|
|
|
nalmefene
|
IV opioid antagonist
for reversal of long-duration opioids like methadone |
|
|
wrist drop, abd pain, microcytic anemia
|
lead
|
|
|
lead treatment
|
IV EDTA and oral succimer or unithiol
|
|
|
osmolar gap, met acidosis, hypoK, resp depression, urinary oxalate
|
ethylene glycol
|
|
|
ethylene glycol treatment
|
fomepizole - inhibits alcohol dehydrogenase
Ca, K, bicarb hemodyalysis |
|
|
fomepizole
|
inhibits alcohol dehydrogenase
for ethylene glycol and methanol |
|
|
GI pain and diarrhea, hypotension, acidosis
|
arsenic - semiconductors, herbicides
treat w/ gut decontamination and chelation |
|
|
chemical pneumonitis, pulm edema, gingivostomatitis, neuro symptoms
|
merculy inhalation
|
|
|
penicillamine
|
copper chealator
|
|
|
succimer
|
water soluble dimercapol
lead, arsenic, mercury |
|
|
unithiol
|
IV or oral
mercury, arsenic, lead dermatologic side effects |
|
|
EDTA
|
IV, exchanges Ca for other metals - produces hypocalcemia
>5 days = nephrotoxicity charged - poor membrane penetration |
|
|
deferoxamine
|
strong iron binding - used for excess iron therapy for anemia and thallasemia
|
|
|
dimercapol
|
IM for arsenic, merucy, lead
crosses cell membranes bicarb promotes renal loss |
|
|
flumazenil
|
for benzo overdose
does not reverse resp depression in barb overdose |
