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21 Cards in this Set
- Front
- Back
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Chronic Myeloproliferative Disorders are a ______ proliferation of ______ cells (not _____, but maturing cells) in blood and bone marrow.
Occurs in ______ only |
malignant
myeloid blasts Adults |
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Chronic Myeloproliferative Disorders:
Chronic myeloid leukemia __________ vera Essential ____________ ______ myelofibrosis |
Polycythemia
thrombocythemia Chronic |
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Which cell is associated with which chronic myeloproliferative disorder?
CML platelets PV everything ET red cells MF neutrophils |
CML - neutrophils
PV - red cells ET - platelets MF - everything! |
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Feautres common to all 4 disorders:
Occur only in _____ Long clinical course ↑ ___ with left shift Hypercellular ______ Big ______ |
adults
WBC marrow spleen |
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Which one is this?
Neutrophilic leukocytosis Basophilia Philadelphia chromosome Three phases |
Chronic Myeloid Leukemia
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CML lab findings:
↑ ↑ ↑ WBC Neutrophilia with left shift Basophilia _____ hemoglobin _____ platelet count (at first) ↓ Leukocyte alkaline phosphate (what is this?) |
decreased
increased - at first Shows benign neurophilic proliferation - malignant don't have it |
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3 phases of CML:
Chronic phase: _____ counts, easily controlled w/ chemo ________ phase: _____ counts, fatal within months ______ crisis: fatal within weaks |
stable
Accelerated unstable blast |
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The best treatment for CML is what?
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Imatinib
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Which conditions is this?
Panmyelosis… …then marrow fibrosis Extramedullary hematopoiesis Teardrop red cells |
Myelofibrosis
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Chronic Myelofibrosis:
Left upper quadrant fullness due to huge _____ Weakness, fatigue, pallor ____cardia |
spleen
tachycardia |
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How do you treat Chronic Myelofibrosis?
What is the prognosis? _____ transformation in some patients |
Supportive, maybe myelosuppressive drugs early on
Live 3-5 years - death from marrow failure leukemic |
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Which condition is this?
High RBC in blood (makes blood sludgy) Different from secondary polycythemia! Thrombosis and hemorrhage Jak-2 mutation |
Polycythemia vera
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Which condition has a Jak-2 mutation?
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Polycythemia vera
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There are two forms of polycythemia vera:
Primary - intrinsic _____ cell problem Secondary - due to increased _______ |
myeloid
erythropoietin |
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Headache, pruritis, dizziness, thrombosis, infarction, big spleen/liver, and plethora are all signs and symptoms of which condition? Why?
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Polycythemia Vera
Big RBC, sludge blood |
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What is the main treatmen for polycythemia vera?
What is the prognosis?\ _______ transformation in some patients |
Phlebotomy (maybe myelosuppressive drugs)
Mean survival: 9-14 yrs Leukemic |
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Which condition is this?
Very high platelet count in blood Can occur in young women Diagnosis of exclusion Hemorrhage and thrombosis |
Essential Thrombocythemia
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Essential Thrombocythemia:
_______ count >600,000 Hgb <13 or ___ mass normal No ________ chromosome No marrow ______ No other reason for thrombocytosis |
Platelet
RBC Philadelphia fibrosis |
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bleeding (acquired vWf), thrombosis, purpura, bruising, pallor, tachycardia, and slightly bigger spleen are all signs of what?
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Essential Thrombocythemia
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Treatment of Thrombocythemia:
_____ pheresis _________ drugs Aspirin Prognosis? ________ transformation in some patients |
platelet
myelosuppressive 5-8 years (death by thrombosis or hemorrhage) leukemic |
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which has the best prognosis?
worst? |
CML (good chemo drugs)
Polycythemia vera next (9-14) Essential Thrombocythemia (5-8 yrs) CHronic Myelofibrosis worst (3-5 years) |
