3. Immunopathology

Front 1

Natural killer cells:

Back 1

large granular lymphocytes in peripheral blood

Front 2

IgM and IgG synthesis:

Back 2

begin after birth

Front 3

Class I MHC:

Back 3

present on nucleated cells

Front 4

APCs:

Back 4

B cells, macrophages, dendritic cells

Front 5

CD4 cells:

Back 5

secrete cytokines (IL-2 leads to proliferation of CD4/CD8 T cells; y-interferon activation of macrophages); help B cells become antibody producing plasma cells

Front 6

y-interferon:

Back 6

(sec by CD4), leads to activation of macrophages (pg 43)

Front 7

CD8 cells:

Back 7

kill virus-infected, neoplastic, and donor graft cells

Front 8

B cells:

Back 8

Differentiate into plasma cells that produce immunoglobulins to kill encapsulated bacteria, Act as APCs that interact with CD4 cells

Front 9

Natural killer cells:

Back 9

Kill virus-infected and neoplastic cells

Front 10

Macrophages:

Back 10

Involved in phagocytosis and cytokine production, Act as APCs

Front 11

Dendritic cells:

Back 11

Skin (Langerhans' cells), germinal follicles, Act as APCs

Front 12

GVH reaction:

Back 12

jaundice, diarrhea, dermatitis

Front 13

Antiacetylcholine receptor:

Back 13

Myasthenia gravis

Front 14

Anti-basement membrane:

Back 14

Goodpasture syndrome

Front 15

Anticentromere:

Back 15

CREST syndrome

Front 16

Antiendomysial and antigliadin

Back 16

Celiac diease

Front 17

Anti-insulin

Back 17

Type 1 diabetes

Front 18

Anti-intrinsic factor:

Back 18

Pernicious anemia

Front 19

Anti-islet cell:

Back 19

(no disease listed)

Front 20

Anti-parietal cell:

Back 20

(no disease listed)

Front 21

Antimicrosomal:

Back 21

Hashimoto's thyroiditis

Front 22

Antithyroglobulin:

Back 22

(no disease listed)

Front 23

Antimitochondrial:

Back 23

primary biliary cirrhosis

Front 24

Antimyeloperoxidase:

Back 24

Microscopic polyangiitis

Front 25

Antiproteinase 3:

Back 25

Wegener's granulomatosis

Front 26

Antiribonucleoprotein:

Back 26

Mixed connective tissue disease

Front 27

Anti-thyroid-stimulating hormone receptor:

Back 27

Grave's disease

Front 28

Most common cardiac finding in SLE:

Back 28

fibrinous pericarditis with effusion

Front 29

Procainamide:

Back 29

most common drug associated with drug-induced lupus

Front 30

Drug-induced lupus:

Back 30

antihistone antibodies

Front 31

Systemic sclerosis:

Back 31

excess collagen deposition

Front 32

Raynaud's phenomenon:

Back 32

most common initial sign of systemic sclerosis

Front 33

Systemic sclerosis:

Back 33

anti-topoisomerase antibodies

Front 34

CREST syndrome=

Back 34

calcinosis, Raynaud's phenomenon, esophageal dysfunction, sclerodactyly, telangiectasia

Front 35

MCTD- Mixed conn tissue dlo:

Back 35

antiribonucleoprotein antibodies

Front 36

Bruton's agammaglobulinemia:

Back 36

Defects: Failure of pre-B cells to become mature B cells (opsonization effect), Mutated Tyrosine kinase. Clinical features: Sinopulmonary infections.

Front 37

IgA deficiency:

Back 37

Defects: Failure of IgA B cells to mature into plasma cells. Clinical Features: Sinopulmonary infections, giardiasis.

Front 38

Common variable immunodeficiency:

Back 38

Defects: Defect in B-cell maturation to plasma cells, Adult immunodeficiency disorder.

Front 39

DiGeorge syndrome:

Back 39

Failure of third and fouth pharyngeal pouches to develop, Thymus and parathyroids fail to develop

Front 40

Severe Combined immunodeficiency (SCID):

Back 40

Defects:Adenosine deaminase deficiency; adenine toxic to B and T cells. Clinical features: Defective CMI, decrease immunoglobulins

Front 41

Wiskott-Aldrich syndrome:

Back 41

Defects: Progressive deletion of B and T cells. Clinical features: Symptom triad: eczema, thrombocytopenia, sinopulmonary infections. Defective CMI, decrease IgM, normal IgG, increase IgA and IgE.

Front 42

Ataxia-telangiectasia:

Back 42

Defects: mutation in DNA repair enzymes, Thymic hypoplasia. Clinical Features: Cerebellar ataxia, telangiectasias of eyes and skin.

Front 43

Anti-gp120 for HIV:

Back 43

detected in ELISA test screen

Front 44

Hereditary angioendema:

Back 44

deficiency of C1 esterase, Continued C1 activation decreases C2 and C4 and increases their cleavage products, which have anaphylatoxic activity. Normal C3.

Front 45

C2 deficiency:

Back 45

Most common complement deficiency, septicemia, lupus-like syndrome

Front 46

C6-C9 deficiency:

Back 46

increased susceptibility, Neisseria gonorrhoeae, N. meningitidis

Front 47

Paroxysmal nocturnal hemoglobinuria:

Back 47

Defect in molecule anchoring decay accelerating factor (DAF), normally degrades C3 and C5 convertase. COmplement-mediated intravascular lysis of red blood cells (hemoglobinuria), platelets, and neutrophils.

Front 48

Amyloid:

Back 48

abnormal folding of protein