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37 Cards in this Set
- Front
- Back
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Most common cause of anemia
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Fe deficiency
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What does Fe need to be reduced to, to be absorbed?
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Fe++
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How is Fe++ absorbed
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by active transport
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What are s/s of iron toxicity?
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gastroenteritis, V, bloody diarrhea, shock, lethargy, dyspnea, met. aciddosis, coma, death
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How do you treat Fe toxicity
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bowel irrigation
deferoxamine (chelator) |
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Term for chronic iron overload
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hemochromatosis
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Treatment for chronic Fe tox.
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phlebotomy
deferasirox |
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What needs to be present in the stomach for b12 to be absorbed?
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intrinsic factor
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What two compounds are converted to active B12?
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cyanobalamin
hydroxocobalamin |
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B12 is necessary for what 2 reactions?
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DNA synthesis
methionine synthesis |
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If b12 is decreased what can it result in?
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megaloblastic anemia
neurologic effects |
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What 2 drugs contribute to decreased FA
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Methotrexate
Phenytoin |
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Where is erythropoeitin produced
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kidneys
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What does erythropoetin stimulate?
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Inc. rbc
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What are the 3 myeloid growth factors
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G-CSF
GM-CSF PEG filgrastin |
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What do the myeloid growth factors stimulate?
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Inc. neutrophils
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What are myeloid growth factors useful for?
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neutropenia d/t Ca chemo-neutrophil recovery
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Where is interleukin-11 produced?
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fibroblasts & stromal cells in bone marrow
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What does interleukin-11 do?
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Inc. platelets and neutrophils
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Cholesterol synthesis pathway
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Acetyl CoA->
HMG CoA-> mevalonic acid-> cholesterol-> bile acids |
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Where is HDL secreted from
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liver
intestines |
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HDL function
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retrieve cholesterol from artery wal
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Name of the protein that transports cholesterol into artery wall
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apo B100
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DOC for treating hyperlipidemia
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Statins
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How do statins works
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Inhibit HMG CoA
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Pregnant or lactating women shouldn't take statins d/t risk of
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rhabdomyolysis (musc. breakdown)
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How does Niacin work?
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Dec. VLDL secretion by liver
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What blocks niacin?
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ASA, ibuprofen
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Drugs that Dec. VLDL, and Inc. lipoprotein lipase
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Gemfibrozil
Fenofibrate |
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Drugs that inc. bile acid clearance-> inc. conv. of cholesterol to bile acids
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colestipol
cholestyramine colesevelam |
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Drug that inhibits intestinal absorbtion of cholesterol
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Ezitimibe
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DOC for thyroid hormone replacement
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levothyroxine
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What thyroid hormone is most potent?
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T3-shorter T1/2, higher cost
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Drugs that block Iodine organification
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Methimazole
PTU |
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Drugs that block reuptake of iodide
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Perchlorate
Pertechnetate Thiocyanate |
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Autoimmune disease of hyperthyroidism
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Graves
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How would you treat Graves dz in child? adult?
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chilld: methimazole or PTU
adult I131 |
