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8 Cards in this Set
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adjuvant
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any substance that enhances the immune response against an antigen with which it is co-administered.
Most adjuvants work by activating the innate immune response and inducing co-stimulatory signals, thus jump-starting the adaptive immune response. |
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B7
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a surface molecule expressed by professional antigen presenting cells that interacts with CD28 expressed by T cells to provide a co-stimulatory signal to T cells
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interleukin-2 (IL-2)
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a cytokine produced by T cells that induces the proliferation of T cells
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lymphokine activated killer (LAK) cells
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derived from natural killer cells by stimulation with IL-2 in vitro; they will kill tumor cells in a non-specific way
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transforming growth factor β
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produced by monocytes, T cells and by some tumors; inhibits cell growth and inflammation
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tumor antigens
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antigens that are expressed by a tumor and that are able to induce a protective immune response in the host
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tumor infiltrating lymphocytes (TIL)
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derived from cytotoxic T lymphocytes; they kill tumor cells in an antigen-specific and MHC-restricted fashion
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tumor surveillance hypothesis
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the hypothesis that cancer cells frequently arise in the body, and that the immune system is constantly on the lookout for such cells and eliminates them.
This hypothesis was generally accepted in the 60s and 70s, largely abandoned in the 80s and 90s, but is now coming back. |
