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13 Cards in this Set
- Front
- Back
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RBC normally live up to how long?
Made where? |
120 days
Bone marrow |
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The bone marrow in a normal individual can ^ its production of RBCs up to ___ fold to compensate for bleeding, therefore if your average RBC lifespn v to ___ days or less, you will become anemic
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8 fold
15 days or less |
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In hemolytic anemia Hb or Hct is v a a rate greater than ___ or Hb & Hct stable and there is a v ____?
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1% per day
reticulocyte count |
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Increased reticulocyte count reflects
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^ in Bone Marrow activity
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3 causes for Intrinsic hemolytic anemias
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1)Hemoglobinopathies
2)Thalassemias 3)Enzyme problmes (ie G6PD deficiency) |
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List some extrinsic causes of Hemolytic anemias
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Trauma (ie march hemoglobinuria)
Heat stroke Frote bite Toxins Antibody (ie transfusion medicine) Vasculitis |
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Adult Hemoglobin consists of what chains?
Fetal? difference |
Adult - 2 alpha & 2 beta
Fetus - 2 alpha & 2 gamma Gamma has a higher affinity for O2 than beta therfore being able to rob the mother of her O2 |
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Hb O2 binding follows what kind of graphical curve?
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Signmoid
Holds 4 O2's Mostly gain/lose 3rd and 4th O2's Rarely lose 2nd O2 and never lose 1st |
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More phosphate does what to the affinity of Hb for O2?
Name a situation where the ^ in phosphate would happen |
Phosphate in form of 2,3 DPG
decreases the affinity of Hb for O2 RIGHT SHIFT Example: people with severe renal failure retain phosphate |
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Alpha or Beta Hemoglobinopathies are more significant?
Examples? |
Beta
1)Hb-S: sickle cell; produce rigid RBC & form liquid crystal within the cell to prevent shape change and block small BV Hb-C: hemolysis and RBC membrane damage like SC anemia but not to the same extent (BV not occluded) Causes big spleen and anemia, but not end organ damage |
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Biochemical change in SC anemia?
Hb C change? |
SC anemia: Glu->Val on 6th position from N-terminal end of beta chain
Hb C: Glu->Lys on 6th position from N-terminal end of beta chain |
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Area that is Particularly vulnerable to damage in sicle cell?
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Hip - neck of the femur is susceptible b/c there is no collateral circulation
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T/F You can be heterozygous w/ Hb-S & Hb-C?
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T, screwed worse than just Hb C but not as bad as Hb S
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