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13 Cards in this Set

  • Front
  • Back
RBC normally live up to how long?

Made where?
120 days

Bone marrow
The bone marrow in a normal individual can ^ its production of RBCs up to ___ fold to compensate for bleeding, therefore if your average RBC lifespn v to ___ days or less, you will become anemic
8 fold

15 days or less
In hemolytic anemia Hb or Hct is v a a rate greater than ___ or Hb & Hct stable and there is a v ____?
1% per day

reticulocyte count
Increased reticulocyte count reflects
^ in Bone Marrow activity
3 causes for Intrinsic hemolytic anemias


3)Enzyme problmes (ie G6PD deficiency)
List some extrinsic causes of Hemolytic anemias
Trauma (ie march hemoglobinuria)

Heat stroke

Frote bite


Antibody (ie transfusion medicine)

Adult Hemoglobin consists of what chains?

Fetal? difference
Adult - 2 alpha & 2 beta

Fetus - 2 alpha & 2 gamma

Gamma has a higher affinity for O2 than beta therfore being able to rob the mother of her O2
Hb O2 binding follows what kind of graphical curve?

Holds 4 O2's

Mostly gain/lose 3rd and 4th O2's

Rarely lose 2nd O2 and never lose 1st
More phosphate does what to the affinity of Hb for O2?

Name a situation where the ^ in phosphate would happen
Phosphate in form of 2,3 DPG

decreases the affinity of Hb for O2


Example: people with severe renal failure retain phosphate
Alpha or Beta Hemoglobinopathies are more significant?


1)Hb-S: sickle cell; produce rigid RBC & form liquid crystal within the cell to prevent shape change and block small BV

Hb-C: hemolysis and RBC membrane damage like SC anemia but not to the same extent (BV not occluded)

Causes big spleen and anemia, but not end organ damage
Biochemical change in SC anemia?

Hb C change?
SC anemia: Glu->Val on 6th position from N-terminal end of beta chain

Hb C: Glu->Lys on 6th position from N-terminal end of beta chain
Area that is Particularly vulnerable to damage in sicle cell?
Hip - neck of the femur is susceptible b/c there is no collateral circulation
T/F You can be heterozygous w/ Hb-S & Hb-C?
T, screwed worse than just Hb C but not as bad as Hb S