2012 Nsp Week 5 Pharm

Front 1

Tiagabine

Back 1

GABAergic AEDsGABA uptake inhibitorAdjunct for partial seizures with or without secondary generalization.Contraindicated in patients with absence generalized seizures.no

Front 2

Vigabatrin

Back 2

GABAergic AEDsGABA-T inhibitorRefractory partial seizures in adults and infantile spasms in patients who are refractory to other treatments.Long term therapy can cause peripheral field visual effects in 30-50% of patientsno

Front 3

Phenobarbital

Back 3

GABAergic AEDsPotentiates GABAa receptorspartial and generalized tonic-clonic seizuresUGT induction reducing oral contraceptivesyes

Front 4

Benzodiazepines

Back 4

GABAergic AEDsPotentiates GABAa receptorsstatus epilipticus, absence seizuresTolerance limits long term useno

Front 5

lorazepam

Back 5

GABAergic AEDsstatus epilipticus IV

Front 6

clonazepam

Back 6

GABAergic AEDsAbsense seizures

Front 7

clorazepate

Back 7

GABAergic AEDsadjunct in partial seizures

Front 8

diazepam

Back 8

GABAergic AEDs

Front 9

Felbamate

Back 9

Glutamatergic AEDsInhibits NMDA receptors, also enhances GABAA receptors, inhibits high frequency firingParial seizures, seizures in Lennox-Gastaut syndromeaplastim anemia, hepatitsno

Front 10

Phenytoin

Back 10

Na Channel ModulatorsIncreases time of Na channel in inactive statepartial and generalized tonic-clonic seizuresgingival hyperplasia, hirsutism, teratogenyes

Front 11

Carbamazepine

Back 11

Na Channel ModulatorsIncreases time of Na channel in inactive statesimple and complex partial and generalized tonic-clonic seizures, trigeminal neuralgiacomayes

Front 12

Valproic Acid

Back 12

Na Channel ModulatorsProlongs recovery of V-G Na channel, also inhibits T-type Ca currentspartial, absence, myoclonic and tonic-clonic seizuresTeratogen-neural tube defects, GIno

Front 13

Lamotrigine

Back 13

Na Channel ModulatorsProlongs recovery of V-G Na channelPartial seizures and secondary generalized tonic-clonic seizures in adults, Lennnox-Gastaut syndrome, absence seizures in childrenno

Front 14

Topiramate

Back 14

"Na Channel ModulatorsBlocks repetitive firing of neurons, activates hyperpolarizing K channel,potentiates currents at GABAA receptors,Inhibits activation of AMPA type glutamate receptorsPartial and generalized tonic-clonic seizures, Lennox-Gastaut syndromekidney stones, acute myopia and glaucoma, teratogenic"

Front 15

Rufinamaide

Back 15

Na Channel ModulatorsProlong the inactive state of V-G Na channelsAdjunctive therapy for Lennox-Gastaut syndromeyes

Front 16

Lacosamide

Back 16

Na Channel ModulatorsEnhances slow inactivation of V-G Na channelsAdjunct therapy for partial-onset seizures with or without secondary generalizationno

Front 17

Ethosuximide

Back 17

Ca Channel ModulatorsInhibits T-type Ca channelsabsence seizuresno

Front 18

Zonisamide

Back 18

Ca Channel ModulatorsInhibits T-type Ca channels & prolongs inactivated state of V-G Na channelsadjunct therapy for partial seizuresno

Front 19

Trimethadione

Back 19

Ca Channel ModulatorsInhibits T-type Ca channelsabsence seizuresTeratogenno

Front 20

Gabapentin

Back 20

Ca Channel Modulatorsbinds to a2-d1 subunit of V-G Ca+ channelpartial seizures and generlized tonic-clonic seizures, neuralgiano

Front 21

Pregabalin

Back 21

Ca Channel Modulatorsbinds to a2-d1 subunit of V-G Ca+ channelpartial seizures and generlized tonic-clonic seizuresno

Front 22

Ezogabine

Back 22

Potassium Channel Modulatorsenhances neuronal K channelsadjunct for partial seizuresno

Front 23

Levetiracetam

Back 23

OtherBinds to SV2A protein on synaptic vesiclesAdjunctive therapy for partial seizures and primary generalized tonic-clonic seizures and monoclinic seizures of juvenile myoclonic epilepsyno