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14 Cards in this Set
- Front
- Back
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Alpha/Beta T Cell Receptors:
All T cells express? |
All express a TCR
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Alpha/Beta T Cell Receptors::
95% express what kind of TCR? Remaining 5% are? |
95% express an alpha/beta
5% express a gamma/delta |
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Alpha/Beta T Cell Receptors:
All TCRs are expressed in association with? |
CD3
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Alpha/Beta T Cell Receptors:
CD3 does what? |
transduces signal
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Alpha/Beta T Cell Receptors:
Alpha/beta TCR recognizes peptide antigen bound to? |
MHC Class I
or MHC Class II |
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Major Histocompatibility Complex (MHC) comprises a stretch of ________ that encode proteins associated with __________ and _________.
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tightly linked genes
intercellular recognition antigen presentation to T lymphocytes |
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MHC Class I - Alpha Chain
Describe - External Domain? - Transmembrane? - Cytoplasmic Tail? - Encoding? |
3 External Domain
1 Transmembrane 1 Cytoplasmic Tail Encoded in MHC |
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MHC Class I - Beta-2 Microglobulin
Describe - External Domain? - Transmembrane? - Cytoplasmic Tail? - Encoding? |
1 External Domain
No Transmembrane No Cytoplasmic Tail Not encoded in MHC |
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MHC Class II - Alpha Chain
Describe - External Domain? - Transmembrane? - Cytoplasmic Tail? - Encoding? |
2 External Domain
1 Transmembrane 1 Cytoplasmic Tail Encoded in MHC |
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MHC Class II - Beta-2 Microglobulin
Describe - External Domain? - Transmembrane? - Cytoplasmic Tail? - Encoding? |
2 External Domain
1 Transmembrane 1 Cytoplasmic Tail Encoded in MHC |
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MHC Class I Proteins:
- Tissue distribution? |
All NUCLEATED cells
(RBCs in some species, but not humans) |
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MHC Class I Proteins:
- Function? |
Presentation of antigens to CD8+ T cells.
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MHC Class II Proteins:
- Tissue distribution? |
Antigen Presenting Cells
Thymic Epithelium B cells Macrophages Dendritic cells |
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MHC Class II Proteins:
- Function? |
Presentation of antigens to CD4+ T cells.
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