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27 Cards in this Set
- Front
- Back
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An enzyme in the latter part of the pentose phosphate pathway that requires thiamine pyrophosphate is
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transketolase
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Corticosteroids cause a decrease in the production of the major classes of eicosanoids by
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inhibiting phospholipase A2
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lipocortin is a protein that is an inhibitor of a particular
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phospholipase
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Cholesterol levels in patients can be lowered by inhibiting____ the rate limiting step enzyme for cholesterol biosynthesis by using drugs such as Lovastatin
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hydroxymethyl glutaryl CoA reductase HMG CoA reductase
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The rate limiting step of gluconeogenesis is catalyzed by the enzyme
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pyruvate carboxylase
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In order to exhibit coordinate control of glycolysis versus gluconeogenesis, fructose 2,6 bisphosphate both allosterically inhibits fructose 1,6 bisphosphatase and activates
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PFK1
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In anaerobic glycolysis, the NADH required for the lactate dehydrogenase reaction is supplieed by ____ reaction
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glyceraldehyde 3 phosphate dehydrogenase
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In order for gluconeogenesis to take place in the kidney, the enzyme glucose 6 phosphatase, located in the ____ is utilized
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endoplasmic reticulum
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Which portion of the cholestertol biosynthesis pathway can also provide geranyl pyrophosphate and farnesyl pyrophosphate for the biosynthesis of the hemeA sidechain, coenzyme Q 10, dolichol and farnesylated G proteins?
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The reactions going from isopentenyl pyrophosphate to squalene.
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A cholesterol lowering pharmaceutical approach using indigestible polymres such as Cholestyramine removes ____ from enteroheptaic circulation
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Bile acids and bile salts
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A positive allosteric effector for the PFK 1 reaction that is utilized in the liver but not in the muscle is
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fructose -2,6- bisphosphate
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Counting only the ATP investment and ATP generating phases of glycolysis, without counting the use of pyruvate or NADH elsewhere, the glycolysis pathway generates ____ NET ATP from each glucose molecule
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2
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Which of the following is FALSE regarding the metabolite glucose-6-phosphate?
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Glucose-6-phosphate is converted into UDP glucose catalyzed by the enzyme UDP-isomerase
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True statements about glucose-6-phosphate include
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1. g6p is formed from g1pby the enzyme phosphoglucomutase.
2. g6p through HMP shunt (PPP) forms ribose 5- phosphate 3.g6p can eventually be converted through glycolysis into two molecules of pyruvate 4. g6p is converted into glucose by the enzyme glucose 6 phosphatase |
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Von Gierkes patients are hypoglycemic because they lack
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enzyme glucose 6 phosphatase
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If the (alpha 1-4)-(alpha 1-4) glucan transferase activity of the debranching enzyme is defective, during the process of glycogenolysis the glycogen molecule
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would contain four residues at the branch point.
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In type 1 diabetes
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the blood glucose levels are always high and the excess glucose can be non specifically converted to glucitol which can be the sole source of retinopathy
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Which of the following enzymes is deficient in Hers disease
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glycogen phosphorylase
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Biotin (vitamin B7/vitamin H derivative) serves as a coenzyme for
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Acetyl CoA carboxylase
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Which of the following enzyme/protein activities of the mammalian fatty acid synthase requires NADPH as a coenzyme
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enoyl coA reductase
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An individual experiences muscle weakness and hypoketosis. Which of the following abnormalities can best explain the above conditon?
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defective carnitine acyl transferase I
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Methylmalonyl CoA mutase requires ____ as a coenzyme
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Vitamin B12 derivative
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About ten percent of the incidents of SIDS are attributed to the deficiency of
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medium chain acyl coA dehydrogenase
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Which of the following compounds is a ketone body
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bethydroxybutyrate
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inability to degrade phytanic acid
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refsums disease
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vitamin B12 is missing.
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this can cause aciduria due to the deficiency of methylmalonylcoa mutase and the accumulation of methylmalonayr
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which of the following is allosterically inhibited by malonyl coa?
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carnitine acyl transferase 1
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