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83 Cards in this Set

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Abs made in absence of t-cells (eg AIDS)
IgM (need Tcells and ADA for class switching)
c-reactive protein
acute-phase reactant: increase during any inflam process
Common variable immunodeficiency (CVID)
usu acquired, various etiologies; recurrent bac infections following decreased Ab levels. a/w other AI conditions, lymphomas
None
CVID vs X-linked agammaglobulinemia
CVID has normal B cell count, XLA has decreased
HIB Vax structure
Hemophilus capsular Ags + Diptheria toxoid. Toxoid causes t-cell involvement --> class type switching, memory
Ab in SLE with prognostic significance
Anti-dsDNA
Ab in mixed connective tissue disease
Anti-RNP
Ab in myositis/dermatomyositis
Anti-Jo-1, ANA
Form of hypersensitivity in urticaria
Type I (Immediate type hypersensitivity) -- preformed IgE bound to mast cells / basophils --> vasoactive + spasmogenic substance relase
Warthin-Finkeldey (WF) giant cell
MEASLES; unlike most giant cells (histiocyte fusion), these are fused lymphocytes -- eosinophilic cytoplasm with nuclear inclusion bodies; found in LN
CD3
All T-lymphocytes
CD20
B-Cell
B cell markers
CD19, CD20, CD21 (EBV receptor)
EBV Receptor
CD21
CD56
NK Cell marker
IFN-gamma
product of TH1 cells, stimulates macrophages
IFN-alpha
product of leukocytes, inhibits viral replication; used to tx Hep B, Hep C, Kaposi Sarcoma, and Hairy Cell Leukemia
IFN-beta
product of fibroblasts, inhibits viral replication; used to tx MS
IL-2
product of TH cells that causes proliferation of other lymphocytes
TNF-alpha
product of M0 and NK cells -- cytotoxic for tumor cells, induces cytokine production, causes cachexia
Wiskott-Aldrich syndrome
XR; (WIPE): recurrent infections, thrombocytopenia, hepatosplenomegaly, eczema; death < 6yo (infection, bleeding); Tx: BMT from HLA-identical sibling
Immunodeficiency causing recurrent n.meningitis
deficiency in complement factors C6, C7, C8 (MAC, kills G-)
C1q deficiency (Sx)
combined immunodeficiency w/ SLE-like syndrome
C1rs, C1s, C4, C2 defiencies (Sx)
SLE-like syndrome + glomerulonephritis
C3 or C5 deficiency Sx
pyogenic infection
B-cell deficiency symptoms
pyogenic infections
T-cell deficiency --> what infections?
opportunisitic (candida, PCP, CMV)
Macrophage Cell Surface markers
CD14, c3b receptor, Fc receptor
NK Cell surface markers
CD16, MHC I receptor
Th cell surface markers
CD3, TCR, CD40L, CD28 (binds B7), CD4
Anti-histone Ab
Ab in drug-induced lupus
Anti-centromere Ab
Ab in CREST Scleroderma
Anti-Scl-70 Ab
Ab in Diffuse Scleroderma
Anit-Jo-1 Ab
Ab in polymyositis, dermatomyositis
Anti-microsomal Ab
Ab in Hashimoto's Thyroiditis
Anti-mitochondrial Ab
Ab in Primary Billiary Cirrhosis (PBC)
HLA B27
HLA a/w PAIR arthritides (Psoriasis, Ankylosing Spondylitis, Inflammatory Bowel Disease, Reactive Arthritis / Reiter's Syndrome)
HLA B8
HLA a/w "Bait with ______ to your grave" = Celiac Sprue, Graves Disease
HLA DR2 and 4
HLA a/w Lyme disease polyarthritis
None
HLA DR2
HLA a/w "I DREW (DR2) BUTTERFLIES in MarthaStewart's (MS) HAY PASTURE": SLE, MS, Hay Fever, Goodpasture's
HLA DR3
HLA a/w DM I, Sjogren's Syndrome
HLA DR4
HLA a/w DM I (+DR3), Rheumatoid Arthritis, Lyme Disease Polyarthritis (+DR2?)
None
HLA DR5
HLA a/w Pernicious Anemia, Hashimoto's (5 Microsomes)
HLA DR7
HLA a/w Steroid-Response nephoritic Syndrome
HLA A3
HLA a/w Primary Hemochromatosis
HIB Vax composition
polyribitol phosphate capsular polysaccharides coupled to protein carrier
Hantavirus pulmonary syndrome
fever, myalgia, rapid dev of respiratory failure --> death; usu in southwest (Jared-land)
Role of C5a
chemo-attractant (PMNs)
Role of C3b
opsonization
HIV Testing: EIA/ELISA
high sensitivity, checks for anti-HIV Abs; positive result should be followed by confirmatory test (Western, PCR)
Giardia
protozoan parasite, exists exclusively within intestinal lumen --> IgA critical for defense
Ascarsis lumbricoides
Giant roundworm, eggs in feces, intestinal infection
Entamoeba Histolytica
Bloody diarrhea, often followed by liver abscess
Bacterial causes of hepatic abscesses
E.Coli, Klebsiella, Streptococcus, Staph, Bacteroides, Pseudomonas
Sausage Digits (Dactylitis)
Reiter's (germans like sausage) and psoriatic arhtritis
None
Microorganisms that can trigger Reiter's Arthritis
Chlamydia, Yersinia Shigella, Salmonella, Campylobacter
Infectious causes of atherosclerosis
Chlamydia pneumoniae, CMV
S.Pneumo vs Klebsiella
Both pulm pathogens, but Klebsiella has greater tendency to progress to abscess and empyema
Pseudomonas vs Klebsiella
Both cause bilateral bronchopneumo; Klebsiella has cavitary lesions
None
Lobar pneumo
S.pneumo: consolidation, intra-alveolar exudate
Bronchopneumonia
S.aureus, H.flu, Klebsiella, S.pyogenes: acute inflam infiltrates from bronchiles into adjacent alveoli
Interstitial (atypical) pneumonia
Mycoplasma, Chlamydia, Viral, Legionella: Diffuse patchy interstitial inflammation
Enterobius vermicularis (pinworm)
the Enterobus takign the females to lay their eggs in the perianal region -- if the bus tire gets popped by a pin(worm), use scotch tape (test)
Cysticerci (cysts in the brain)
consequence of Taenia Solium (tapeworm); also affects heart, skel muscle, and skin
Theophylline
inhbits PDE --> increases cAMP levels --> inhibiting mast cell degranulation
Type of hypersensitivity in Rheumatic Fever
Type II (Anti-Strep Abs cross-reacting against connective tissue)
Most common agents used to tx. Traveller's diarrhea
Fluroquinolones (good against ETEC, Shigella, C.jejuni) in adults, TMP-SMX in kids
northern blot
rna
southern blot
dna
western blots
proteins
defect in marfan's
fibrillin (component of elastic-associated microfibrils)
I cell disease
defect in mannose phosphorylation (occurs in golgi) --> lysosomal enzomes exocytosed --> physical deformities, psychomotor and growth retardation, cardiorespiratory failure --> death < 10yo
CK- {MB, MM, BB}
Creatine Kinase {cardiac, skeletal muscle, brain}
Aminoacidopathies, general Sx
Present after few days of life with: feeding difficulties, lethargy, seizures, liver disease, renal disease, and coma; urine often has characteristic odor
Carbohydrate Metabolism Defects: general sx
Present w/ hypoglycemia, hepatosplenomegaly, lactic acidosis, or ketoacidosis
FA oxidation defect: general sx
hypoketotic hypoglycemia, hyperammonemia, cardiomyopathy
Organic acidemias: general sx
metabolic acidosis w/ ketosis, elevated lactate, mild-moderate hyperammonemia, vom, encephalopathy, neutro/thrombocytopenia
Urea cycle defects: general sx
hyperammonemia, respiratory alkalosis
Vit E deficiency
hyporeflexia, distal muscle weakness, ataxia, decreased vibratory sens / proprioception, night blindness
serine protease functions
cleave proteins at serine residue; e.g. trypsin, chymotrypsin, plasmin, thrombin, plasminogen, cathepsin G, elastase;
Maternal PKU
teratogen, crosses placenta --> MR, birth defects
CF Delta508 mutation effects on protein
interferes with proper protein folding
Molec defect in familial hypercholesterolemia
ApoB-100 Receptor