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4 Cards in this Set
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affinity maturation of Ab
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affinity maturation of Ab:
- occurs in ln, after Ag interaction - B cell proliferation: Ig mutations lead to same epitope but higher Ag affinity - low affinity cells: apoptosis - affinity in 100-10,000 fold - low dose of Ag stimulates selection of B cells with high affinity Ab |
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Ab class switching
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Ab class switching:
- only TD Ag!!!!!!! - enables Ab specificity to remain constant while biological effector activities of molecule can vary (Ig class) - involves interaction with Th cells via CD40/40L - those without CD40L only make IgM |
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influences on Ab class switching
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influences on Ab class switching:
1. Th1 and Th2 cytokines 2. microenvironment 3. repeated Ag exposure: secondary immune response |
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secondary humoral immune response
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generation of memory B cells allows for secondary humoral immune response to Ag
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